Transdetermination in Drosophila imaginal discs: a model for understanding pluripotency and selector gene maintenance

Maves, Lisa; Schubiger, Gerold

doi:10.1016/j.gde.2003.08.006

Cited by 52 publications

(42 citation statements)

References 58 publications

(66 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All of them display a proximal shortening of the wing blade. In one of these lines, wg signaling, which has a demonstrated role in determination and transdetermination events (reviewed in Maves and Schubiger 2003), might be affected. One line (B2037, Figure 3.29) displayed a leg phenotype similar to that of B1164: the proximal part of the leg was reduced and not shapely.…”

Section: Discussionmentioning

confidence: 99%

“…A role for chromatin-interacting proteins has also emerged in a study investigating transdetermination of the eye (Katsuyama et al 2005). Interestingly, many of these factors are also important for the specification of identity, as it occurs during development (reviewed in Maves and Schubiger 2003). This raises the question of whether transdetermination and developmental determination are related.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Misexpression Screen in Drosophila melanogaster Aiming to Reveal Novel Factors Involved in Formation of Body Parts

et al. 2007

View full text Add to dashboard Cite

To identify novel factors that lead a fly imaginal disc to adopt its developmental fate, we carried out a modular dominant misexpression screen in imaginal discs. We have identified two factors that appear to change the fate of the respective body structure and appear to lead to the transformation of a body part. In one mutant line, notum tissue, normally derived from wing imaginal tissue, formed close to the site of the sternopleural bristles, which are leg disc derivatives. In the other line, the arista is transformed into a tubular structure, resembling an abnormal leg. We found that ectopic expression of abrupt was responsible for this potential transformation of the arista.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Misexpression Screen in Drosophila melanogaster Aiming to Reveal Novel Factors Involved in Formation of Body Parts

et al. 2007

View full text Add to dashboard Cite

show abstract

“…2) (Gehring, 1966;Johnston & Schubiger, 1996;Maves & Schubiger, 1998;Schneuwly, Kuroiwa, & Gehring, 1987;Wildermuth, 1968). Weak points are located along the A/P compartment boundaries in different imaginal discs and are identified by their proliferative ability during regeneration (Johnston & Schubiger, 1996;Maves & Schubiger, 2003). For example, two days after leg disc fragmentation, cell division ceases throughout the entire disc except for cells at the weak point (Kiehle & Schubiger, 1985; (Fig.…”

Section: The Weak Pointmentioning

confidence: 99%

Transdetermination: Drosophila imaginal disc cells exhibit stem cell-like potency

McClure

Schubiger

2007

The International Journal of Biochemistry & Cell Biology

Self Cite

View full text Add to dashboard Cite

Drosophila imaginal discs, the primordia of the adult fly appendages, are an excellent system for studying developmental plasticity. Cells in the imaginal discs are determined for their disc-specific fate (wingness, legness) during embryogenesis. Disc cells maintain their determination during larval development, a time of extensive growth and proliferation. Only when prompted to regenerate do disc cells exhibit lability in their determined identity. Regeneration in the disc is mediated by a localized region of cell division, known as the regeneration blastema. Most regenerating disc cells strictly adhere to their disc-specific identity; some cells however, switch fate in a phenomenon known as transdetermination. Similar regeneration and transdetermination events can be induced in situ by misexpression of the signaling molecule wingless. Recent studies indicate that the plasticity of disc cells during regeneration is associated with high morphogen activity and the reorganization of chromatin structure. Here we provide both a historical perspective of imaginal disc transdetermination, as well as discuss recent findings on how imaginal disc cells acquire developmental plasticity and multipotency. We also highlight how an understanding of imaginal disc transdetermination can enhance an understanding of developmental potency exhibited by stem cells.

show abstract

“…Cells in this region displayed an efficient loss of Hth upon Antp expression, upregulation of Dac expression, overgrowth and generation of ectopic leglike appendages. The switching of fate seen in this region is comparable in many aspects to transdetermination of a regenerating disc (Schubiger, 1971;Hadorn, 1978, reviewed in Maves andSchubiger, 2003). Transdetermination depends on the ability of cells to proliferate, and thus, it depends on Dpp activity (Maves and Schubiger, 1998) and on cellular functions that promote undifferentiated states and resetting of chromatin structure (Klebes et al, 2005).…”

Section: Does Loss Of Asx Cause Transdetermination?mentioning

confidence: 98%

“…Cells in the weak point are characterized by increased cell division and by their ability to express selector genes that are normally expressed in other types of discs (reviewed in Maves and Schubiger, 2003).…”

Section: Does Loss Of Asx Cause Transdetermination?mentioning

confidence: 99%

Additional sex combs affects antennal development by means of spatially restricted repression of Antp and Wg

Halachmi¹,

Schulze²,

Inbal³

et al. 2007

Developmental Dynamics

View full text Add to dashboard Cite

Additional sex combs (Asx) is thought to function in protein complexes of both the Trithorax and Polycomb groups, but very little is known about its developmental roles. Here, we present a detailed analysis of Asx's role in antennal development. We show that loss of Asx in the antennal disc causes a complex phenotype, which consists of distal antenna-to-leg transformations and outgrowth of ectopic leg-like appendages from the Dpp-expressing domain of the disc. Our analyses suggest that these phenotypes are caused mainly by segment-specific de-repression of Antp and expansion of wg expression. We thus conclude that Asx functions normally to repress Antp and to restrict wg expression in specific regions of the developing disc. We also show that, in the absence of Asx's function, Antp expression does not lead to efficient repression of the antennal-determining gene hth, suggesting that Asx is also required for the repression of hth by Antp.

show abstract

Transdetermination in Drosophila imaginal discs: a model for understanding pluripotency and selector gene maintenance

Cited by 52 publications

References 58 publications

Misexpression Screen in Drosophila melanogaster Aiming to Reveal Novel Factors Involved in Formation of Body Parts

Misexpression Screen in Drosophila melanogaster Aiming to Reveal Novel Factors Involved in Formation of Body Parts

Transdetermination: Drosophila imaginal disc cells exhibit stem cell-like potency

Additional sex combs affects antennal development by means of spatially restricted repression of Antp and Wg

Contact Info

Product

Resources

About