2009
DOI: 10.1016/j.tiv.2009.06.030
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Transepidermal water loss for probing full-thickness skin barrier function: Correlation with tritiated water flux, sensitivity to punctures and diverse surfactant exposures

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Cited by 30 publications
(24 citation statements)
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“…No correlation between TEWL and skin integrity was found, however this may be due to the use of different experimental protocols. Variations in TEWL values recorded by different MN groups are well recognised, which may be due to variation between the skin samples/models used, the lack of universal calibration between equipment, variability between experimental protocols, differences in atmospheric temperatures and the susceptibility for inaccuracies at high vapour flux rates [53,64]. TEWL studies also provide no information on the depth of MN insertion and are highly sensitive to the hydration status of the skin.…”
Section: Transepidermal Water Loss (Tewl) Monitoringmentioning
confidence: 99%
“…No correlation between TEWL and skin integrity was found, however this may be due to the use of different experimental protocols. Variations in TEWL values recorded by different MN groups are well recognised, which may be due to variation between the skin samples/models used, the lack of universal calibration between equipment, variability between experimental protocols, differences in atmospheric temperatures and the susceptibility for inaccuracies at high vapour flux rates [53,64]. TEWL studies also provide no information on the depth of MN insertion and are highly sensitive to the hydration status of the skin.…”
Section: Transepidermal Water Loss (Tewl) Monitoringmentioning
confidence: 99%
“…The measurement of TEWL is a well-established method in dermatology to assess, in vivo or in vitro, the integrity of the skin barrier [17]. When the skin is impaired, an increase in water loss occurs [18,19]. In this work, skin was treated with Transcutol P ® , batyl alcohol/Transcutol P ® , or chimyl alcohol/Transcutol P ® .…”
Section: Discussionmentioning
confidence: 99%
“…These values do not significantly differ from each other (t-test: P = 0.38). Moreover, these TEWL values are low enough to indicate that all the test skins were intact in terms of skin barrier function [13]. Each value in µg represents the mean ± standard error of the mean.…”
Section: Tewl Readingsmentioning
confidence: 99%