Pulmonary vein stenosis is a rare but serious complication of pulmonary vein isolation to treat atrial fibrillation. Pulmonary vein angioplasty/stenting has emerged as the treatment of choice for significantly stenotic veins. Guidelines for post ablation evaluation of the pulmonary veins, including the timing and method of surveillance for possible stenosis, the criteria for intervention, the technical aspects of intervention, and finally the surveillance post intervention, are still being developed. The relatively high rate of restenosis after intervention in a subset of patients remains a great challenge. A better understanding of the pathophysiology underlying this syndrome is needed to appropriately answer many of the remaining questions. The goal of this manuscript is to describe what has been learned about this complication and its treatment from a relatively large experience in a single institution over the past decade, and provide a comprehensive review of the existing literature in order to shed as much light on the subject as is possible, while at the same time exposing the areas that need further study.www.jafib.com 27 Jan-Feb, 2010 | Vol 2 | Issue 4 decline. [9][10][11][12][13][14][15] Recognizing that there is no consensus at this time on routine screening for pulmonary vein stenosis after PVI, 16 we followa protocol at our institution to assure that the small number of patients who still develop significant pulmonary vein stenosis is not missed. Imaging is performed 3 months following PVI, and repeated 3 months later only if significant stenosis is detected at the time of the first scan.Detailed anatomy of the pulmonary veins is best defined by electrocardiographically (ECG)-gated contrast-enhanced multidetector computed tomogram (MDCT) [ Figure 1]. Frequently, images are acquired with retrospectively gated helical scanning. However, despite the use of dosemodulation, these protocols are associated with higher radiation exposure. Therefore, with recent advances in scanner technology, there is a trend to scanning with prospectively triggered protocols in patients with controlled heart rate. In those patients with fast and irregular heart rate, scanning with spiral non-gated imaging is a good alternative. Images are reconstructed with overlapping 1.00-to 1.25-mm slice thickness for analysis with multiplanar reconstructions, maxi mal intensity projections, and volume rendered imaging. Semi-automated analysis and display software supports the evaluation of the images.Cardiac MRI is an excellent alternative modality, and avoids exposure to ionizing radiation. It has been used in clinical care and clinical research, but is more expensive (at least in the United States) and time-consuming.17 Transesophageal echocardiography has been considered as a screening tool also to avoid radiation exposure, but it is not always possible to evaluate each pulmonary vein with 100% sensitivity when compared to MDCT, and it is not possible to evaluate the anatomy in detail if an interventional procedure is necess...