In this study, a hybrid deep-learning model termed as ODANN, built upon neural networks (NN) coupled with data assimilation and natural language processing (NLP) features extraction methods, has been constructed to concurrently process daily COVID-19 time-series records and large volumes of COVID-19 related Twitter data, as representative of the global community’s aggregated emotional responses towards the current pandemic, to model the growth rate in the number of confirmed COVID-19 cases globally via a proposed G parameter. Overall, there were 3 key components to ODANN’s development phase, namely: (i) data hydration and pre-processing were performed on COVID-19 related Twitter data ranging between 23 January 2020 and 10 May 2020, which amounted to over 100 million Tweets written in English language; (ii) multiple NLP features extraction methods were subsequently leveraged to encode the hydrated Twitter data into useful semantic word vectors for training ODANN under an optimal set of hyperparameters; and (iii) historical time-series data of defined characteristics were also assimilated into ODANN’s selected hidden layer(s) to model the G parameter daily with a lead-time of 1 day. By far, our experimental results demonstrated that by adopting a rolling time-window size of 5 days, with respect to the number of historical time-series records for assimilating different data features, enabled ODANN to outperform other traditional time-series models and recent studies, in terms of the computed RMSE and MAE scores attained from the model’s testing step. Overall, the summarized results from ODANN demonstrated its competitive edge in modelling and forecasting the growth rate in the number of COVID-19 cases globally.