Transfer of maternal colostral leukocytes promotes development of the neonatal immune system

Reber, A.; Donovan, Douglas C.; Gabbard, Jon D.; Galland, K.; Aceves-Avila, M.; Holbert, K.A.; Marshall, Lewis W.; Hurley, David J.

doi:10.1016/j.vetimm.2008.02.009

Cited by 88 publications

(75 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We think that this could be the consequence of possible immune activation that hinders further bacterial replication. Ingestion of maternal colostral leukocytes immediately after birth promotes development of the immune system in newborn calves (49). Since M. bovis depletion in colostrum was elicited by vaccination, our immunization strategy might help to control its transmission and enhance resistance in newborns fed fresh colostrum.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium bovis DNA Detection in Colostrum as a Potential Indicator of Vaccination Effectiveness against Bovine Tuberculosis

Herrera-Rodríguez

Gordiano-Hidalgo

López-Rincón

et al. 2013

Clin Vaccine Immunol

View full text Add to dashboard Cite

Bovine tuberculosis (bTB) remains a problem on many dairy farms in Mexico, as well as a public health risk. We previously found a high frequency of Mycobacterium bovis DNA in colostrum from dairy cows using a nested PCR to detect mpb70. Since there are no reliable in vivo tests to determine the effectiveness of booster Mycobacterium bovis BCG vaccination against bTB, in this work we monitored M. bovis DNA in colostrum by using this nested PCR. In order to decrease the risk of adverse reactions in animals likely containing viable M. bovis, a single application of BCG and a subunit vaccine (EEP-1) formulated with M. bovis culture filtrate proteins (CFP) and a copolymer as the adjuvant was performed in tuberculin skin test-negative cattle (TST ؊ ), while TST reactor animals (TST ؉ ) received EEP-1 only. Booster immunization using EEP-1 was applied to both groups, 2 months after primary vaccination to whole herds and 12 months later to lactating cows. Colostrum samples were collected from 6 farms where the cows were vaccinated over a 12-month period postvaccination and, for comparison, from one control farm where the cows were not vaccinated with comparable bTB prevalence. We observed an inverse relationship between the frequency of M. bovis DNA detection and time postvaccination at the first (P < 0.001) and second (P < 0.0001) 6-month periods. Additionally, the concentration of gamma interferon (IFN-␥) was higher in mpb70 PCR-positive colostrum samples (P ‫؍‬ 0.0003). These results suggest that M. bovis DNA frequency in colostrum could be a potentially useful biomarker for bTB vaccine efficacy on commercial dairy farms.

show abstract

Section: Discussionmentioning

confidence: 99%

Mycobacterium bovis DNA Detection in Colostrum as a Potential Indicator of Vaccination Effectiveness against Bovine Tuberculosis

Herrera-Rodríguez

Gordiano-Hidalgo

López-Rincón

et al. 2013

Clin Vaccine Immunol

View full text Add to dashboard Cite

show abstract

“…Researchers have demonstrated that maternal leukocytes transferred to the neonatal calf have the ability to respond to several antigens (Reber et al 2005, Donovan et al 2007, Reber et al 2008a, 2008b.…”

Section: Introductionmentioning

confidence: 99%

“…mune response than calves fed acellular colostrum (COL-) (Riedel-Caspari & Schmidt 1991a, 1991b, 1991c, 1991d. At this time, we are aware of only five papers published on the impact of transferred maternal cells on calf immune development (Reber et al 2005, 2006, 2008a, 2008b, Langel et al 2015.…”

Section: Introductionmentioning

confidence: 99%

Specific immune response in neonate Holstein heifer calves fed fresh or frozen colostrum

et al. 2017

View full text Add to dashboard Cite

The objective of this study was to evaluate the influence of viable cells from colostrum on immune development in dairy heifer calves during the first 28 days of life. The animals were distributed between 2 groups: COL+ (n=9) receiving fresh whole colostrum from their own damns; and COL-(n=10) receiving pooled frozen colostrum, containing no viable cells, from a pool of donor cows. These calves were assessed before colostrum intake (D0), 48 hours of age (D2), and weekly from D7 to D28. The development of immunity was evaluated by assessment of the phenotype of blood leukocyte subsets, and induced cytokine production after 72 hours of stimulation in culture with concanavalin A (ConA), killed Staphylococcus aureus (S.aureus) and killed Escherichia coli (E. coli) by peripheral blood mononuclear cell (PBMC). The clinical history of these calves was marked by a high frequency of diarrhea in both groups. However, COL-had greater diarrhea intensity scores (fecal score~3 of 4), and rectal temperature on D7 than COL+ calves. Moreover, bronchopneumonia (n=1) and navel inflammation were observed only in COL-calves. COL-had a lower concentration of serum iron, and a higher absolute number of lymphocytes on D7 than COL+. COL-also had a higher percentage of anemic calves than the COL+ calves on D21 and D28. In general, the percent of cells within each subset of leukocytes was similar between the groups over the experiment, except on week 1 when COL-calves had a higher percentage of lymphocytes expressing CD45RO + (P=0.07). A steady increase in CD45RO + and concomitant decline in CD45RO -leukocytes was observed over the course of the study, indicating the development of immune memory. The proportion of CD14MHCII + leukocytes increased with age (P≤0.05). The median background cytokine production by PBMC that were not stimulated was below the level of detection of the assays used for both groups. The PBMC from COL+ calves stimulated with ConA secreted a larger quantity of IL-17 week 2 (COL+=2060.0pg/mL and COL-=0.0pg/mL, P=0.00). PBMC from COL+ calves stimulated with killed S. aureus whole cell antigen (P=0.05) and killed E. coli whole cell antigen (P=0.05) also secreted higher levels of IL17 than COL-calves at week 4. Clear production of IL17 was observed in PBML from COL+ calves at week 2, but the difference was not statistical different between groups. In conclusion, calves fed fresh and frozen colostrum showed no difference in cells subset profile overall. The increased percentage of leukocytes expressing the memory CD45RO + or CD14MHCII + over the course of the experiment indicated a maturation of the adaptive immune response after natural exposure to pathogens in the + aumentou de acordo com a idade (P≤0.05). As medianas das citocinas produzidas a partir do PBMC não estimuladas apresentaram valores abaixo do nível de detecção em ambos os grupos. O PBMC do COL+ estimulado com ConA secretou elevada concentração de IL17 na semana 2 (COL+=2060.0pg/mL e COL-=0.0pg/ml, P=0.00). PBMC do COL+ estimuladas com S. aureus inativado (P...

show abstract

“…They derive passive immunity by absorbing immunoglobulins and leukocytes from the colostrum [2,[4][5][6]. Protection from infectious diseases of newborn calves is completely dependent on the success of passive transfer of maternal IgG via the colostrum [2].…”

Section: Introductionmentioning

confidence: 99%

“…Protection from infectious diseases of newborn calves is completely dependent on the success of passive transfer of maternal IgG via the colostrum [2]. Because of that, failure of passive transfer (FPT) of colostral immunoglobulins, composed mainly of IgG [2], is associated with increased morbidity and mortality [2][3][4][5][6][7][8][9][10][11]. FPT of immunoglobulins is defi ned as a circulating IgG concentration less than 10 g/L in newborn calves between 24 and 48 hours of age [12,13].…”

Section: Introductionmentioning

confidence: 99%

Brix Refractometry of Colostrum from Primiparous Dairy Cows and New-Born Calf Blood Serum in the Evaluation of Failure of Passive Transfer

et al. 2017

View full text Add to dashboard Cite

Failure of passive transfer (FPT) of immunoglobulins (IgG) is associated with increased morbidity and mortality of calves. In this study we evaluated the digital Brix refractometer usefulness for the assessment of FPT. A number of 16 colostrum samples from the fi rst milking (2-3h post-partum) of Holstein-Friesian dairy heifers and 29 blood sera of 3-6 days old calves were analyzed with a digital Brix refractometer. Total proteins were determined by the biuret reaction. Colostral IgG were determined by radial immunodiffusion (RID), and colostral whey and blood serum γ globulin (composed almost entirely of IgG) were determined by agarose protein gel electrophoresis (APE) and densitometry. Colostral % Brix score was 25.5±3.4%. Concentrations of colostrum IgG and colostral whey γ globulin were 130±33 g/L and 100±24 g/L respectively. The concentration of total proteins in colostral whey was 134±30 g/L. The correlations between Brix values and the concentrations of IgG determined with RID and the concentrations of γ globulin determined with APE were positive and highly signifi cant (P<0.001 and P<0.01). The concentration of serum proteins of new-born calves was 57.75±11.8 g/L, the concentration of γ globulin was 14.4±7.8 g/L, and the Brix score was 8.6±1.0%. FPT (serum γ globulin<10 g/L) was detected in 34.5% (10/29) calves. Brix score correlated with the concentration of blood serum γ globulins in all examined calves. The results have confi rmed that digital Brix refractometry allows the producers to use this technique in order to estimate colostral and calf serum IgG, thereby monitoring both colostrum quality and success of passive transfer.

show abstract

Transfer of maternal colostral leukocytes promotes development of the neonatal immune system

Cited by 88 publications

References 32 publications

Mycobacterium bovis DNA Detection in Colostrum as a Potential Indicator of Vaccination Effectiveness against Bovine Tuberculosis

Mycobacterium bovis DNA Detection in Colostrum as a Potential Indicator of Vaccination Effectiveness against Bovine Tuberculosis

Specific immune response in neonate Holstein heifer calves fed fresh or frozen colostrum

Brix Refractometry of Colostrum from Primiparous Dairy Cows and New-Born Calf Blood Serum in the Evaluation of Failure of Passive Transfer

Contact Info

Product

Resources

About