Transferrin as a muscle trophic factor

Ozawa, Eijiro

doi:10.1007/bfb0032676

Cited by 17 publications

(9 citation statements)

References 363 publications

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“…Transferrins are glycoproteins which reversibly bind iron and help control free iron levels [64]. Transferrins have been identified in different species as a myotrophic factor stimulating the proliferation of myoblasts and satellite cells in culture [65][66][67]. Furthermore, in a study on the effects of chronic hypoxia Lopez-Barneo et al [68] observed that hypoxia induces upregulated expression of glucose degradation enzymes and transporters, including transferrin, in muscle.…”

Section: Discussionmentioning

confidence: 99%

2D DIGE proteomic analysis of early post mortem muscle exudate highlights the importance of the stress response for improved water‐holding capacity of fresh pork meat

et al. 2013

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Variation in water-holding capacity (WHC), which presents a major economic burden to the swine industry, is considered to be underpinned by variation at a molecular and biochemical level. High-resolution 2D DIGE followed by MS analysis and Western blot were used to unravel the proteome of muscle exudate, collected following centrifugation, in the pH 4-7 range. A first 2DE-based protein map of this substrate was produced where 89 spots were successfully characterised. Two phenotypes divergent for WHC plus one intermediate were compared with a view to deciphering the biochemical processes impacting on variation in WHC. Twenty spots were observed to be altered across the phenotypes. Of these, 14 represented sixteen proteins including metabolic enzymes, stress response proteins and structural proteins. Triosephosphate isomerase and transferrin showed a major difference between the two extreme phenotypes, and may have potential as biological markers for WHC prediction. Several members of the HSPs family were highlighted. This proteomic study makes an important contribution towards a more detailed molecular view of the processes behind WHC and will provide a valuable resource for future investigations.

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Section: Discussionmentioning

confidence: 99%

2D DIGE proteomic analysis of early post mortem muscle exudate highlights the importance of the stress response for improved water‐holding capacity of fresh pork meat

et al. 2013

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“…Futhermore, eled apotransferrin. It is thought that mammalian transpreliminary in vitro studies on single isolated myofibers ferrins are interchangeable with regard to receptor speciand in vivo studies in newborn animals suggest transficity, 38 therefore human transferrin was used in place of ferrin-LPDII has very low ability to transduce myofibers mouse transferrin in all binding studies. Specific activities (unpublished observations).…”

Section: Methodsmentioning

confidence: 99%

Selection and use of ligands for receptor-mediated gene delivery to myogenic cells

Feero

Rosenblatt

et al. 1997

Gene Ther

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Identification of myogenic cell targeting ligands is a critical observed in regenerating fibers of patients with Duchenne step in the development of synthetic vectors for gene delivmuscular dystrophy and the ability to direct a large enzyme ery to skeletal muscle. Here we describe the screening of conjugate to the cytoplasm of myotubes. Finally, we show six potential targeting ligands (insulin, insulin-like growth that incorporation of transferrin into an artificial virus confactor I, iron transferrin, gallium transferrin, alpha-bungarosisting of poly-L-lysine-condensed DNA coated with a lipid toxin and carnitine) for their ability to bind dystrophinshell (LPDII formulation) results in ligand-directed delivery deficient myotubes in vitro. Those ligands showing high of DNA to myogenic cells. This is the first report of gene levels of binding to myotubes were then tested on fully diftransfer to myogenic cells using a ligand-directed synthetic ferentiated, isolated, viable myofibers. Of the ligands vector. These results suggest that rational design of ligandtested, transferrin showed the most promise based on high directed, fully synthetic, gene delivery vehicles is a viable levels of binding to myogenic cells, high levels of receptor approach to skeletal muscle vector development.

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“…The more highly expressed Tf could therefore be interpreted as a mechanism to compensate the hypoxia generated by decreased blood supply or increased metabolic demand. Furthermore, Tf has also been identified in different species as a myotrophic factor stimulating the proliferation of myoblasts and satellite cells in culture (Ozawa, 1989;Graziadei, 1998). Moreover, Tf levels are greatest when the proliferative demands of fetal tissues are at a peak, indicating a mitogenic effect of Tf independent of its ability to supply iron to proliferating tissues (Meek and Adamson, 1985).…”

Section: Regulatorsmentioning

confidence: 99%

Proteomic analysis of ovine muscle hypertrophy1

Hamelin¹,

Sayd²,

Chambon³

et al. 2006

Journal of Animal Science

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Two-dimensional electrophoresis was used to investigate the effects of a QTL for muscle hypertrophy on sarcoplasmic protein expression in ovine muscles. In the Belgian Texel breed, the QTL for muscle hypertrophy is localized in the myostatin-encoding gene. Based on microsatellite markers flanking the myostatin gene, we compared the hypertrophied genotype with the normal genotype. The average age of the sheep was 3 mo. Among the 4 muscles studied, in the hypertrophied genotype only the vastus medialis was normal, whereas the semimembranosus, tensor fasciae latae, and LM were hypertrophied. In the hypertrophied genotype, these muscles showed upregulation of enzymes involved in glycolytic metabolism together with oxidative metabolism in LM. Certain chaperone proteins, including glutathione S-transferase-Pi, heat shock protein-27, and heat shock cognate-70, were also more highly expressed, probably due to increased use of energetic pathways. Expression of the iron transport protein transferrin was increased. Alpha-1-antitrypsin was the only protein showing a similar pattern of expression (i.e., less expressed) in all 4 muscles of the hypertrophied genotype. It is suggested that transferrin and alpha-1-antitrypsin may interact to reinforce myogenic proliferative signaling.

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Transferrin as a muscle trophic factor

Cited by 17 publications

References 363 publications

2D DIGE proteomic analysis of early post mortem muscle exudate highlights the importance of the stress response for improved water‐holding capacity of fresh pork meat

2D DIGE proteomic analysis of early post mortem muscle exudate highlights the importance of the stress response for improved water‐holding capacity of fresh pork meat

Selection and use of ligands for receptor-mediated gene delivery to myogenic cells

Proteomic analysis of ovine muscle hypertrophy1

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