Transferrin-decorated thymoquinone-loaded PEG-PLGA nanoparticles exhibit anticarcinogenic effect in non-small cell lung carcinoma via the modulation of miR-34a and miR-16

Abstract

The detailed molecular mechanism of transferrin-tagged thymoquinone nanoparticle mediated apoptotic induction in non-small cell lung carcinoma showing the involvement of p53 dependent synergistic activation of miR-34a and miR-16 in the pathway.

MicroRNA and ROS Crosstalk in Cardiac and Pulmonary Diseases

“…A positive feedback loop was found between ROS and p53 and related to the miR-34 and miR-16-dependent apoptosis following TQ-TF-nanoparticle treatment, both in vitro and in vivo. Thus, strict cooperation between miR-34a and miR-16 and ROS production exists, and it accounts for the promising anti-neoplastic effect of the TQ-TF nanoparticles [172].…”

“…In the lung, miR-144 and miR-16 have been reported to work synergistically with miR-34a under oxidative stress conditions. As reported above, miR-144 and miR-16 cooperated with miR-34a to downregulate the antioxidant transcription factor Nrf2 [ 139 , 140 , 141 ] and the anti-apoptotic mitochondrial protein Bcl2, respectively, contributing to oxidative stress [ 172 ]. Their functions were very similar in the context of cardiac disease.…”

Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis

“…Radio-iodinated NPs of folic acid-chitosan specifically bind to overexpressed folate receptors of human ovarian cancer cells (SKOV3) and improve anticancer efficacy through improved cellular internalization and retention [ 195 ]. A PEGylated-PLGA-TQ-NP surface decorated with transferrin potentiated anticancer efficacy of TQ through specific binding with the overexpressed transferring receptor on tumor cells, which decreases dose and improved cellular accumulations of NPs through EPR, as investigated in lung carcinoma A549 cells [ 196 ]. The as1411-conjugated nanodroplets delivered TQ into cancer cells through specific binding with overexpressed nucleolin on the cancer cells surface as investigated in MDA-MB-231 cells [ 197 ].…”

Synergetic effects of thymoquinone-loaded porous PVPylated Fe3O4nanostructures for efficient pH-dependent drug release and anticancer potential against triple-negative cancer cells

“…In the acidic pH, the porous PVPylated Fe 3 O 4 is exposed to acid etching, resulting in the expansion of pores that accelerates sustained drug release. 41 This pore expansion is attributed to high drug release in an acidic environment, which could be due to the diffusion and swelling 42,43 of porous PVPylated Fe 3 O 4 nanocarriers. Therefore, the thymoquinone release rate was attained efficiently under acidic conditions than under basic conditions.…”