Transferrin Microheterogeneity in Fetal Blood

Wu, Youting; Sakamoto, Haruhiko; Kanenishi, Kenji; Tanaka, Satomi; Ueno, Minako; Hata, Toshio

doi:10.1159/000078311

Cited by 8 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In many physiological and pathological conditions, like stress, pregnancy [11, 12], alcoholism [6], liver failure in alcoholics [13] the changes in the number of Tf variants, changes in their proportions, and the presence of completely new variants have been revealed. All of these studies emphasized the important influence of the inflammatory process and oxidative stress on these changes.…”

Section: Introductionmentioning

confidence: 99%

Transferrin changes in haemodialysed patients

Formanowicz

2011

Int Urol Nephrol

View full text Add to dashboard Cite

Transferrin (Tf) is a glycoprotein responsible for iron transport in the human body. Physiologically in reaction with Concanavalin A, Tf occurs in four distinct variants Tf1, Tf2, Tf3 (apo-Tf) and Tf4. It was reported recently that Tf is changing, particularly during acute phase response, taking place among others in end-stage renal disease. In this study, we wanted to find the answer to three main questions: firstly, how Tf is changing in patients treated with maintenance haemodialysis (mHD), secondly, whether there are any Tf changes in the course of mHD treatment, and thirdly, what factors can affect Tf microheterogeneity in these patients. Studies were performed on 80 haemodialysed patients and 21 healthy volunteers. The Tf concentration was determined by the rocket immunoelectrophoresis, and its microheterogeneity was assessed by the ConA crossed immunoaffinity electrophoresis. During the annual observation of the distribution of the Tf variants, we have found both changes of the percentage contents of all Tf variants in the whole Tf concentration and a significant decrease in Tf2, Tf3 and Tf4 serum concentrations. Moreover, we found that decrease in the renal function, duration of mHD, and inflammation may contribute to these above-mentioned changes, which are probably the factors that should be taken into account when explaining the mechanisms of persistence of anaemia in haemodialysed patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Transferrin changes in haemodialysed patients

Formanowicz

2011

Int Urol Nephrol

View full text Add to dashboard Cite

show abstract

“…Correlations have been noted between infant birth weight, serum transferrin concentration and its sialylation in some disorders (e.g. severe preeclampsia), but not in healthy pregnancies [15, 16]. …”

Section: Introductionmentioning

confidence: 99%

The Influence of Tobacco Smoke on Protein and Metal Levels in the Serum of Women during Pregnancy

Wrześniak

Kępińska

Królik³

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

BackgroundTobacco smoking by pregnant women has a negative effect on fetal development and increases pregnancy risk by changing the oxidative balance and microelements level. Smoking affects the concentration, structure and function of proteins, potentially leading to various negative effects on pregnancy outcomes.Methodology/Principal FindingsThe influence of tobacco smoke on key protein fractions in smoking and non-smoking healthy pregnant women was determined by capillary electrophoresis (CE). Concentrations of the proteins α1-antitrypsin, α1-acid glycoprotein, α2-macroglobulin and transferrin were determined by ELISA tests. Total protein concentration was measured by the Biuret method. Smoking status was established by cotinine levels. Cadmium (Cd) and Zinc (Zn) concentrations were determined by flame atomic absorption spectrometry and the Zn/Cd ratio was calculated based on these numbers. Smoking women had a 3.7 times higher level of Cd than non-smoking women. Zn levels decreased during pregnancy for all women. The Zn/Cd ratio was three times lower in smoking women. The differences between the changes in the protein profile for smoking and non-smoking women were noted. Regarding proteins, α1-antitrypsin and α2-macroglobulin levels were lower in the non-smoking group than in the smoking group and correlated with Cd levels (r = -0.968, p = 0.032 for non-smokers; r = −0.835, p = 0.019 for smokers). Zn/Cd ratios correlated negatively with α1-, α2- and β-globulins.Conclusions/SignificanceExposure to tobacco smoke increases the concentration of Cd in the blood of pregnant women and may lead to an elevated risk of pregnancy disorders. During pregnancy alter concentrations of some proteins. The correlation of Cd with proteins suggests that it is one of the causes of protein aberrations.

show abstract

“…Transferrin itself is a glycoprotein, but the function of the sugar residues is not well understood and, interestingly, their profile changes in pregnancy 14,15 . Why this occurs is not known, but it may have a hitherto undiscovered role in iron transfer 16 …”

Section: Introductionmentioning

confidence: 99%

“…14,15 Why this occurs is not known, but it may have a hitherto undiscovered role in iron transfer. 16 The first step in the transfer of iron across the placenta involves transferrin binding to its receptor, the transferrin receptor (TfR), on the apical membrane. At pH 7.4, diferric transferrin has a high affinity for the receptor.…”

Section: Introductionmentioning

confidence: 99%

Role of the placenta in regulation of fetal iron status

et al. 2011

View full text Add to dashboard Cite

During pregnancy, the developing fetus is entirely dependent on its mother for nutrition and waste disposal, which take place almost exclusively across the placenta. The placenta is, however, not just a passive mediator; it can also regulate the rates and amounts of nutrient transported. This is particularly true for iron transport. This review examines how the fetus, and not the mother, regulates iron uptake and transfer across the placenta, how these processes interact, and how the fetus can modulate iron metabolism in the mother.

show abstract

Transferrin Microheterogeneity in Fetal Blood

Cited by 8 publications

References 25 publications

Transferrin changes in haemodialysed patients

Transferrin changes in haemodialysed patients

The Influence of Tobacco Smoke on Protein and Metal Levels in the Serum of Women during Pregnancy

Role of the placenta in regulation of fetal iron status

Contact Info

Product

Resources

About