Transfiguration of Rickettsial Diseases: Tsutsugamushi Disease and Spotted Fever Group Rickettsiosis in Japan.

Tange, Yoshiki; Kobayashi, Yoshinari

doi:10.2169/internalmedicine.32.937

Cited by 2 publications

(2 citation statements)

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“…A single acute serum sample requires using a cut-off antibody titer ranging from 1:10 to 1:400 without hard evidence (7). The representative strains of O. tsutsugamushi in Japan are classified serologically as the Karp, Gilliam, Kato, Irie/Kawasaki, and Hirano/ Kuroki (8). However, commercially, a serologic test is available only for limited strains (9) and serologic cross-reaction renders identification of a specific strain difficult (10).…”

Section: Discussionmentioning

confidence: 99%

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Scrub Typhus-Induced Serious Gastric Ulcer Bleeding

et al. 2011

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A 67-year-old woman presented with melena and general weakness. Upper gastrointestinal (GI) endoscopy revealed multiple ulcers and projectile bleeding in the stomach. She also complained of a 10-day history of a fever and was diagnosed with scrub typhus based on a positive result of the eschar polymerase chain reaction (PCR) testing. She fully recovered with endoscopic hemostasis, and administration of minocycline and omeprazole. In a patient with GI manifestations, scrub typhus, a condition with pathologically systemic vasculitis, should be considered in the possible background in endemic areas. The eschar PCR testing is a rapid and useful diagnostic tool to identify a specific strain.

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Section: Discussionmentioning

confidence: 99%

“…3) (11). The PCR method for identifica- tion of specific strain has been developed for confirmed diagnosis in the early acute stage (8). Recently, eschar has received attention as a diagnostic sample because it can be collected readily and can be the site where O. tsutsugamushi proliferates (12).…”

Section: Discussionmentioning

confidence: 99%

Scrub Typhus-Induced Serious Gastric Ulcer Bleeding

et al. 2011

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The Past and Present Threat of Rickettsial Diseases to Military Medicine and International Public Health

Kelly¹,

Richards²,

Temenak³

et al. 2002

Clinical Infectious Diseases

197

164

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Morbidity and mortality caused by rickettsioses have had a major influence on military activities and public health for >2000 years. The threat posed by the rickettsioses is reviewed, focusing on the impact and epidemiology of those that have adversely influenced wartime operations and the current challenges posed by these diseases. With their uneven worldwide distribution, the discovery of drug-refractory strains of Orientia tsutsugamushi, the increased threat of their use in acts of bioterrorism, frequent deployment of troops to regions of endemicity, and exposures due to increased humanitarian missions, these diseases continue to be a threat to military personnel in the field. Effective strategies to reduce the impact of these diseases include development of effective vaccines, enhanced surveillance, and development of new safe, effective, and odorless repellants. The continuation of a proven, highly productive military infectious disease research program is essential for providing solutions to these daunting tasks.

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Transfiguration of Rickettsial Diseases: Tsutsugamushi Disease and Spotted Fever Group Rickettsiosis in Japan.

Cited by 2 publications

References 13 publications

Scrub Typhus-Induced Serious Gastric Ulcer Bleeding

Scrub Typhus-Induced Serious Gastric Ulcer Bleeding

The Past and Present Threat of Rickettsial Diseases to Military Medicine and International Public Health

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