COVID-19 is a major challenge facing the world economy. Under the circumstances of the epidemic, the macro economy has been greatly impacted, and the global economic development model has changed. So the author aims to analyze the global economy based on existing literature and statistical data. The result shows that in the early days of the epidemic, enterprises were greatly affected. Due to the sluggish development, enterprises had to lay off workers, causing a wave of unemployment. In the middle of the epidemic, the world economy is experiencing severe inflation and unemployment is constantly rising. At the same time, the company continued to reform, transform, and upgrade. Enterprise management has been upgraded, the production structure has changed, and some enterprises have made great contributions to solving social problems, slowing down the economic downturn. In the post-epidemic period, enterprises gradually completed their transformation. At the same time, the government provided relevant policy support and financial guarantees for the recovery of enterprises.