Transformation of p53-Positive Papillary Thyroid Carcinoma to Anaplastic Carcinoma of the Liver following Postoperative Radioactive Iodine-131 Therapy

Abstract

Multiple liver metastases were incidentally detected in the lobe of the liver of an 81-year-old

Anaplastic Transformation of Papillary Thyroid Carcinoma Only Seen in Pleural Metastasis: A Case Report with Review of the Literature

“…The groups of Sotome et al [6] and Solomon et al [7] individually reported a single case of anaplastic transformation developed within the metastatic site in the retroperitoneal region. Takeshita et al [8] described anaplastic transformation of p53-positive papillary thyroid carcinoma, in the liver metastasis, following postoperative radioactive iodine therapy. The authors suggested that radioactive iodine therapy could play a role in anaplastic transformation.…”

“…To date, fewer than 20 cases of anaplastic transformation at the metastatic sites have been reported in the English literature [1,[4][5][6][7][8][9][10][11]. Here, we report an additional case of anaplastic transformation which developed in the pleural metastasis, combined with a literature review.…”

Case report: Different metastatic components from anaplastic thyroid carcinoma in mediastinal and neck lymph nodes simultaneously diagnosed by FNA

“…ATC has been found to metastasize to a variety of locations including lung, bone, and brain . A handful of transformed ATC cases were reported in the submandibular gland, retroperitoneum with involvement of pancreas and kidney, liver, skin, and thyroglossal duct cyst …”

Anaplastic Transformation of Follicular Thyroid Cancer in the Lung, Liver, Bone, and Adrenal Gland

“…3). We recommended additional RAI lung, 5,6,[8][9][10][11] mandible, 12) submandibular space, 13) liver, 14) breast, 15) and shoulder. 16) These cases reported anaplastic transformation from PTC at distant metastatic sites with three exceptions.…”

“…3,7) In these cases, development of anaplastic transformation ranged from 4 to 30 years after the primary diagnosis of DTC. [3][4][5][6][7][8][9][10][11][12][13][14][15][16] Therefore, it should be noted that anaplastic transformation can occur in metastatic sites even after long-term follow-up. …”