In order to solve the problem that postgraduates are affected by the traditional concept of career choice of the native family and their entrepreneurial intention is obviously low, a method to explore the entrepreneurial spirit training model of medical students in Beijing-Tianjin-Hebei colleges and universities from the perspective of mixed big data is proposed. This article chooses to conduct research by conducting a survey on the entrepreneurial willingness of postgraduates in universities in the Beijing-Tianjin-Hebei and its influencing factors. From the perspective of master students from five universities in the Beijing-Tianjin-Hebei region, the selection of personal background information, entrepreneurial attitude, subjective norms, perceived behavior control, and entrepreneurship education index factors establish the index system of the influencing factors of graduate students’ entrepreneurial intention and use the TPB theoretical model and SPSS data statistics and other tools to analyze the obtained data results. The results show that gender, major, place of origin, part-time experience, and entrepreneurial experience of relatives and friends correspond to 0.000, 0.000, 0.482, 0.172, 0.003, and 0.004, respectively. It can be seen that the independent variables, major and place of origin, have no statistical significance. In the statistics of college students’ willingness to start a business, 23.33% of the students said “nothing at all,” and 27.8% of the students said “thought, but would not start a business.” It can be seen that entrepreneurial attitude, subjective norm, and perceived behavioral control all positively affect entrepreneurial willingness, and only learning ability, opportunity grasping ability, self-recognition ability, and decisiveness have a significant effect on entrepreneurial willingness.