Transformed SV3T3 cells have a reduced lysosomal compartment and lower levels of enzyme activity than 3T3 cells

Kundra, Vikas; Dean, Michael F.

doi:10.1016/0014-4827(90)90261-8

Experimental Cell Research

1990

DOI: 10.1016/0014-4827(90)90261-8

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Transformed SV3T3 cells have a reduced lysosomal compartment and lower levels of enzyme activity than 3T3 cells

Vikas Kundra¹,

Michael F. Dean

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Cited by 4 publications

References 26 publications

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Deregulation of protein synthesis as a mechanism of neoplastic transformation

Rosenwald

1996

BioEssays

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Early research on the cell cycle revealed correlations between protein accumulation and cell proliferation. In this review, I describe the data showing that abnormality of cell growth and tumor development are dependent upon oncogene-induced increases in the levels and activity of factors that determine the rate of protein synthesis. It is proposed that the establishment of a vicious circle, namely oncoproteins-->increase in translation-->oncoproteins, is a major biological mechanism that fuels neoplastic growth. The constitutively high rates of protein synthesis and accumulation of proteins, including those necessary for DNA replication and mitosis, would drive cells to excessive proliferation.

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Deregulation of protein synthesis as a mechanism of neoplastic transformation

Rosenwald

1996

BioEssays

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Multiple Mechanisms for the Inhibition of Entry and Uncoating of Superinfecting Semliki Forest Virus

et al. 1997

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Recombinant Semliki Forest viruses (SFV) that express one or none of the viral structural proteins were used to infect cells and to analyze the fate of incoming superinfecting wild-type viruses. It was found that in addition to the previously described block in replication that superinfecting viruses encounter within 15 min of infection, other mechanisms of superinfection inhibition occurred at later times. Over a 6-hr infection period, inhibition was seen in binding of virus to the cell surface, in acid-activated penetration into the cytoplasm, and in uncoating of nucleocapsids. For each of these processes, the inhibitory mechanism was investigated. In summary, we found that infection evoked several independent mechanisms for blocking the entry and uncoating of superinfecting viruses. The results also offered new insights into the normal processes of penetration and uncoating of SFV.

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Regulation of protein degradation in normal and transformed human bronchial epithelial cells in culture

Lee

Jones

Myers

et al. 1992

Archives of Biochemistry and Biophysics

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Transformed SV3T3 cells have a reduced lysosomal compartment and lower levels of enzyme activity than 3T3 cells

Cited by 4 publications

References 26 publications

Deregulation of protein synthesis as a mechanism of neoplastic transformation

Deregulation of protein synthesis as a mechanism of neoplastic transformation

Multiple Mechanisms for the Inhibition of Entry and Uncoating of Superinfecting Semliki Forest Virus

Regulation of protein degradation in normal and transformed human bronchial epithelial cells in culture

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