Transforming growth factor beta 1 regulates production of acute-phase proteins.

Mackiewicz, A; Ganapathi, Mahrukh K.; Schultz, Debra A.; Brabenec, Anne; Weinstein, Joel A.; Kelley, Michael F.; Kushner, Irving

doi:10.1073/pnas.87.4.1491

Cited by 94 publications

(53 citation statements)

References 43 publications

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“…1,2 However, the level of expression and cytokine regulation of individual APPs appears also to be additionally modulated by the action of endocrine hormones 3,4 and growth factors. [5][6][7] Few studies indicated a modest inhibitory effect of epidermal growth factor (EGF) on APPs in cultured hepatic cells. 8,9 However, EGF action on liver cells, in the context of inflammatory mediators as predicted to be present during acute phase response in vivo, during liver regeneration after partial hepatectomy, or during intrahepatic inflammation, [10][11][12] has not been determined.…”

mentioning

confidence: 99%

Modulation of hepatic acute phase gene expression by epidermal growth factor and src protein tyrosine kinases in murine and human hepatic cells

et al. 1999

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mentioning

confidence: 99%

Modulation of hepatic acute phase gene expression by epidermal growth factor and src protein tyrosine kinases in murine and human hepatic cells

et al. 1999

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“…These include interleukin-1 (IL-1) (8,40,49), interleukin-6 (IL-6) (18, 40), tumor necrosis factor (8, 38, 49), transforming growth factor P, (32), and hepatocyte-stimulating factors I to III (4). No single cytokine, however, has yet been shown to induce the increased synthesis of the full spectrum of acute-phase * Corresponding author.…”

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confidence: 99%

A 58-base-pair region of the human C3 gene confers synergistic inducibility by interleukin-1 and interleukin-6.

Wilson¹,

Juan²,

Wilde³

et al. 1990

Mol. Cell. Biol.

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We have cloned the promoter for the human third component of complement (C3) gene and have identified sequences involved in its regulation during the acute-phase response. A construct linking 199 bp of the C3 promoter to the firefly luciferase gene was found to be very responsive to interleukin-1 (IL-1) and modestly responsive to interleukin-6 (IL-6) by transfection analysis in the human hepatoma line Hep3B2. Simultaneous treatment with the two cytokines showed a strong synergy between the actions of the two molecules. A 58-bp fragment (-127 to -70 bp) was shown by 5' and 3' deletional mutagenesis to contain cis-acting elements that mediated both the IL-1 response and the IL-l-plus-IL-6 synergistic response of this promoter. When coupled to a heterologous promoter, this fragment enabled the synergistic induction by IL-1 plus transcription factor CCAAT/enhancer-binding protein (C/EBP), which included the IL-i-responsive elementlike sequence. No differences were seen between the footprints generated by using extracts from unstimulated and IL-i-stimulated Hep3B2 cells. However, gel retardation analyses revealed two IL-i-specific bands. The data suggest that the induction by IL-1 is mediated by a factor belonging to the family of C/EBP-related proteins.The third component of complement (C3) is the pivotal component of the complement system in that it functions in both the classical and alternative pathways of complement activation. It has been estimated that 90% of serum C3 is liver derived (2), with the remainder contributed from a wide range of cell types, including fibroblasts (26, 42), monocytes (7,46), macrophages (7, 12), and some epithelial cells (43,44). C3 is a member of the class of molecules termed acute-phase reactants, proteins produced primarily by the liver whose synthesis is increased in response to tissue injury, infection, or other inflammatory stimuli (reviewed in references 3 and 13). We have used the human hepatoma line Hep3B2 to mimic the acute-phase reaction in vitro (8). These cells increase the synthesis of C3 and other acute-phase proteins in response to conditioned media from stimulated peripheral blood mononuclear cells. Nuclear run-on experiments using Hep3B2 and other hepatoma lines have shown these increases to reflect, at least in part, altered transcription of many of the acute-phase genes, including the C3 gene (our unpublished results; 19).A number of cytokines have been implicated in the induction of the acute-phase reaction (3,13). These include interleukin-1 (IL-1) (8,40,49), interleukin-6 (IL-6) (18, 40), tumor necrosis factor (8, 38, 49), transforming growth factor P, (32), and hepatocyte-stimulating factors I to III (4). No single cytokine, however, has yet been shown to induce the increased synthesis of the full spectrum of acute-phase * Corresponding author.reactants. C3 falls into the subset of acute-phase reactants including mouse serum amyloid A (22, 35) that are primarily responsive to IL-1. Nuclear run-on experiments performed in our laboratory (9) have shown the IL-1...

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“…Of course, complement activation also depends on other signals of the immune system like interleukins. Vaccinations are known to affect the acute phase response through cytokines like IL1, IL6 and TGFB1 that are released during the immune response and in particular trigger the expression of C3 (Castell et al 1989;Mackiewicz et al 1990;Gonzalez-Ramon et al 2000). Unlike other complement components with specific functions, C6-9 assembly has the same function in cell lysis because they are all members of the MAC macromolecule.…”

Section: Associationmentioning

confidence: 99%

Structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs: a review

Khoa¹

2013

Vet. Med. - Czech

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ABSTRACT:The transmission of infectious agents from domestic animals to humans is a matter of particular concern at present. Inoculation can enhance the defences of each individual animal but only in the short term. Certainly, it will be of immense benefit if biotechnology and genetic techniques are applied to farm animal breeding and selection programs to improve productivity, performance and health status as well as for the construction of sustainable animal production systems and promotion of animal welfare. In recent years, efforts to drive candidate genes like cytokines, haptoglobin, complement system, C-reactive protein, a 2-macroglobulin, retinol binding protein, transcortin, etc. associated with immune traits have successfully been studied in human and different animal species. Here, we compared the molecular structure and evaluated the expression tendency of the haemolytic complement activity (HCA) of porcine candidate genes encoding the terminal complement components (TCC) C6-9. The results suggested that (1) high homology of complement genes among mammalian species may open new ways in cure/ treatment of disease; (2) Muong Khuong animals (Vietnamese potbelly pig) have a great genetic potential to improve the health status of pigs; and (3) HCA in the classical pathway can be developed further by different activation modes, with the potential improvement of animal health.

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Transforming growth factor beta 1 regulates production of acute-phase proteins.

Cited by 94 publications

References 43 publications

Modulation of hepatic acute phase gene expression by epidermal growth factor and src protein tyrosine kinases in murine and human hepatic cells

Modulation of hepatic acute phase gene expression by epidermal growth factor and src protein tyrosine kinases in murine and human hepatic cells

A 58-base-pair region of the human C3 gene confers synergistic inducibility by interleukin-1 and interleukin-6.

Structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs: a review

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