Transforming growth factor-beta (TGF-β1) genotype and lung allograft fibrosis

The TNF−α –308, MCP−1 –2518 and TGF−β1 +915 polymorphisms are not associated with the development of chronic lung disease in very low birth weight infants

“…TGF-b 1 concentrations are increased in TA obtained from preterm infants who develop CLD as in other types of lung fibrosis. 7,[16][17][18][19] Increased production of TGF-b 1 in vitro increased risk for lung fibrosis and decline in lung function in cystic fibrosis is associated with the more common +915 G allele. [18][19][20] In our study population, TGF-b 1 +915 G/C polymorphism was not associated with an altered risk for the development of CLD suggesting that factors other than genetic variation at this locus contribute to these outcomes.…”

“…Increased expression of TGF-b 1 has been implicated in the development of lung fibrosis in both animal models and human disease. [16][17][18] A role for TGF-b 1 in the development of CLD in the preterm newborn is suggested by the finding of increased concentrations in TA fluid of infants who develop this complication. 7 Several polymorphisms have been described for the TGF-b 1 gene.…”

“…7 Several polymorphisms have been described for the TGF-b 1 gene. [17][18][19][20] The polymorphism (G-C) located within exon 1 at codon 25 (915 bp downstream of the start point) is associated with decreased production of TGF-b 1 in vitro (C allele). This polymorphism is associated with an increased frequency of lung fibrosis and a more rapid decline of lung function in patients with cystic fibrosis.…”

“…This polymorphism is associated with an increased frequency of lung fibrosis and a more rapid decline of lung function in patients with cystic fibrosis. [17][18][19][20] Recruitment of mononuclear cells to the lung and their subsequent activation is an important pathological feature of lung fibrosis and is regulated by chemotactic cytokines such as monocytes chemoattractant protein-1 (MCP-1). 21 MCP-1 has been implicated in the pathogenesis of chronic inflammatory lung diseases that have a fibrotic component.…”

TGF-β1 Gene Polymorphisms and Peritoneal Equilibration Test Results in CAPD Patients

“…[12] In addition, Arwight et al and Gamel et al also reached the same results. [13] According to these studies, as TGF-βl gene polymorphism increases TGF-βl expression, it may have a direct relation to the increased fibrosis. However, no such study seems to exist.…”