2020
DOI: 10.1186/s13287-020-01603-z
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Transforming growth factor β1 accelerates and enhances in vitro red blood cell formation from hematopoietic stem cells by stimulating mitophagy

Abstract: Background: Generation of red blood cells (RBCs) from hematopoietic stem cells (HSCs) in vitro takes about 21 days, making it unaffordable for clinical applications. Acceleration of the in vitro erythropoiesis process by using small molecules could eventually make the large-scale production of these cells commercially viable. Transforming Growth Factor β1 (TGF-β1) has been shown to have a dose-dependent activity on the HSCs: at high concentration it inhibits, whereas at low concentration it stimulates the HSCs… Show more

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Cited by 24 publications
(13 citation statements)
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“…The upregulation of specific components related to mitochondrial energy metabolism in white hairs suggests that energy metabolism regulates not only hair growth as previously demonstrated ( Flores et al, 2017 ; Mancino et al, 2020 ; Vidali et al, 2014 ) but also HF greying biology. Our findings demonstrating an upregulation of the fatty acid synthesis and metabolism machinery resonate particularly strongly with recent work demonstrating that fatty acid synthesis by FASN ( Fafián-Labora et al, 2019 ) and transport by CPT1a ( Seok et al, 2020 ) are sufficient drivers of cell senescence, and that fatty acid metabolism regulates melanocyte aging biology ( Tang et al, 2019 ). Approaches combining both high molecular and spatial resolution may be particularly informative ( Vyumvuhore et al, 2021 ).…”
Section: Discussionsupporting
confidence: 87%
“…The upregulation of specific components related to mitochondrial energy metabolism in white hairs suggests that energy metabolism regulates not only hair growth as previously demonstrated ( Flores et al, 2017 ; Mancino et al, 2020 ; Vidali et al, 2014 ) but also HF greying biology. Our findings demonstrating an upregulation of the fatty acid synthesis and metabolism machinery resonate particularly strongly with recent work demonstrating that fatty acid synthesis by FASN ( Fafián-Labora et al, 2019 ) and transport by CPT1a ( Seok et al, 2020 ) are sufficient drivers of cell senescence, and that fatty acid metabolism regulates melanocyte aging biology ( Tang et al, 2019 ). Approaches combining both high molecular and spatial resolution may be particularly informative ( Vyumvuhore et al, 2021 ).…”
Section: Discussionsupporting
confidence: 87%
“…Indeed, in cancer patients TGF-β signaling is the most dysregulated signaling pathway in HSPCs, which leads to impaired hematopoiesis, especially erythropoiesis [ 140 ]. In erythroid cells, TGF-β potently inhibits proliferation and self-renewal, but at a low concentration it may accelerate the differentiation of late-stage EPCs by promoting mitophagy [ 83 , 175 , 176 , 177 , 178 ].…”
Section: Cancer-induced Dysregulation Of Erythropoiesismentioning
confidence: 99%
“…In addition to its role in stemness maintenance, exogenous TGF-β1 has been shown to increase the rate of differentiation of HSCs to red blood cells by stimulating mitophagy ( Kuhikar et al, 2020 ). FIP200 is involved in the differentiation of HSCs to mature red blood cells, and therefore, the depletion of FIP200 inhibits erythropoiesis ( Zhang et al, 2015 ).…”
Section: The Physiological Roles Of Autophagy In Different Adult Stem Cells and Related Diseasesmentioning
confidence: 99%