Transforming growth factor-β1 levels in hypertensive patients: association with body mass index and leptin1

Porreca, Ettore; Febbo, Concetta Di; Vitacolonna, Ester; Baccante, Giovanna; Castelnuovo, Augusto Di; Angelini, Antonio; Febo, Francesca; Nisio, Marcello Di; Cuccurullo, Franco

doi:10.1016/s0895-7061(02)02978-3

Cited by 49 publications

(26 citation statements)

References 31 publications

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“…16 Finally, an increased expression of TGFb1 associated with a left ventricular diastolic dysfunction has been reported in experimental and clinical studies suggesting a pathophysiological role of this cytokine in the occurrence and development of myocardial fibrosis. 19,20 To better explain the link between TGFb1 overproduction and diastolic function, all hypertensive patients were further subgrouped according to the European Society of Cardiology Guidelines 26 to detect diastolic dysfunction.…”

Section: Left Ventricular Filling Abnormalities and Obesity-associatementioning

confidence: 95%

“…Patients with microalbuminuria and proteinuria were also excluded since a TGFb1 overproduction has been reported in these conditions. [16][17][18] An accurate diagnostic procedure was performed in all the subjects with suspected coronary heart disease. This includes basal and 24 h ECG, echocardiography and, where necessary, ECG after exercise.…”

Section: Patientsmentioning

confidence: 99%

“…[13][14][15] Overproduction of TGFb1 is involved in obesityassociated hypertension and in the long-term sequelae of hypertension, including LVH, vascular remodelling and progressive renal disease. [16][17][18] Moreover, some recent data suggest that TGFb1 might play a casual role in myocardial fibrosis and diastolic dysfunction both in pressure overload hearts 19 and after heart transplantation. 20 In addition, the blocking of TGFb1 with monoclonal antibodies has been reported to be effective to neutralize myocardial fibrosis.…”

Section: Introductionmentioning

confidence: 99%

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Left ventricular filling abnormalities and obesity-associated hypertension: relationship with overproduction of circulating transforming growth factor β1

et al. 2005

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This study has been designed to evaluate the relationship among transforming growth factor b1 (TGFb1) and some measurements of diastolic function in a population of hypertensive subjects with normal left ventricular ejection fraction. We studied 67 hypertensive outpatients who according to their BMI levels were subdivided into three groups: lean (L), overweight (OW) and obese (OB) hypertensives (HT). Circulating TGFb1 and M-and B-mode echocardiography was determined. All hypertensives were further subgrouped, according to European Society of Cardiology Guidelines, into two subsets of patients with normal diastolic function or with diastolic dysfunction. Prevalence of left ventricular hypertrophy (LVH) was determined in all the groups. TGFb1, left ventricular mass (LVM), LVM/h 2.7 , E-wave deceleration time and isovolumic relaxation time (IVRT) were significantly (Po0.005) higher and E/A velocity ratio was significantly (Po0.05) lower in OW-HT and OB-HT than in L-HT. Prevalence of LVH was significantly higher (Po0.03) in group OB-HT than in L-HT. TGFb1 (Po0.004), LVM/h 2.7 (Po0.001) and prevalence of LVH were (Po0.01) significantly higher in hypertensives with diastolic dysfunction than hypertensives with normal diastolic function. TGFb1 levels were positively correlated with BMI (r ¼ 0.60; Po0.0001), LVM/h 2.7 (r ¼ 0.28; Po0.03), IVRT (r ¼ 0.30; Po0.02) and negatively with E/A ratio (r ¼ À0.38; Po0.002) in all HT. Multiple regression analysis indicated that TGFb1, BMI and IVRT were independently related to E/A ratio explaining 71% of its variability (r ¼ 0.84; Po0.0001). This relationship was independent of LVH, age and HR suggesting that TGFb1 overproduction may be considered a pathophysiological mechanism in the development of left ventricular filling abnormalities in obesity-associated hypertension.

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Section: Left Ventricular Filling Abnormalities and Obesity-associatementioning

confidence: 95%

Section: Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Left ventricular filling abnormalities and obesity-associated hypertension: relationship with overproduction of circulating transforming growth factor β1

et al. 2005

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“…8,9) Porreca and coworkers have reported that TGF-β1 levels are independently associated with obesity in hypertensive patients. 10) The aim of this study was to evaluate the effect of obesity on renal functions and the possible relationship between TGF-β1 and obesity in hypertensive patients.…”

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confidence: 99%

<b>The Relationship Between Obesity and Transforming Growth Factor Beta on Renal Damage in Essential Hypertension</b>

et al. 2007

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SUMMARYThe aim of this study was to evaluate the effect of obesity on renal functions and the possible relationship between TGF-β1 and obesity in hypertensive patients. Seventy newly diagnosed, hypertensive patients (male/female 36/34, aged 45.0 ± 8.0 years) and 30 (male/female 17/13, aged 41.8 ± 7.7 years) normotensive controls were included. Patients in both groups were analyzed for serum levels of glucose, creatinine, uric acid, lipids, and TGF-β1. A 24-hour urine sample was also obtained; creatinine clearance rate and urinary albumin excretion (UEA) were investigated. TGF-β1 levels were significantly higher (40.7 ± 13.6 versus 34.2 ± 12.1 pg/mL, P = 0.02), and creatinine clearance was significantly lower in patients compared with controls (98.9 ± 25.5 versus 124.5 ± 23.1 mL/min. per. 1.73 m 2 , P = 0.001). Serum TGF-β1 levels (45.2 ± 14 versis 38.0 ± 12.8 pg/mL, P = 0.03), creatinine clearance rates (109.8 29.9 versus 93.0 ± 20.8 mL/min. per. 1.73 m 2 , P = 0.001), and urinary albumin excretion (55.7 ± 62.0 versus 12.7 ± 12.6 mg/24 h, P = 0.002) were higher in obese hypertensive patients than in nonobese patients. In hypertensive patients, TGF-β1 levels correlated with body mass index (r = 0.296, P = 0.01) and creatinine clearance (r = 0.238, P = 0.04). The results suggest that increased body mass index is associated with increased creatinine clearance, urinary albumin excretion, and TGF-β1 levels in essential hypertension. In addition, TGF-β1 is positively correlated with body mass index and creatinine clearance in patients with essential hypertension. (Int Heart J 2007; 48: 733-741)

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“…Sin embargo, no siempre se evidencia HTA en la obesidad, por lo que deben existir estos factores genéticos 33,[43][44][45] . Antecedentes familiares de HTA y obesidad son factores de riesgo de HTA.…”

Section: Factores Genéticosunclassified

Mecanismos de hipertensión en obesidad

Fez¹,

Gaztelu²,

Rubio³

et al. 2004

Anales Sis San Navarra

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RESUMENLa obesidad es una enfermedad crónica, considerada un factor de riesgo importante en el desarrollo de enfermedad coronaria, hipertensión, insuficiencia y fallo renal.La obesidad contribuye a la hipertensión por mecanismos tales como: resistencia insulínica e hiperinsulinemia, aumento de la actividad adrenérgica y de las concentraciones de aldosterona, retención de sodio y agua e incremento del gasto cardíaco, alteración de la función endotelial, a través de moléculas como leptina y adiponectina y factores genéticos. Quedan aún abiertas muchas vías de investigación.Los IECA y/o los ARA II son fármacos de primera elección por su efecto beneficioso sobre la resistencia insulínica y actividad simpática.Palabras clave. Hipertensión. Obesidad. Hiperinsulinemia. Sistema renina-angiotensina-aldosterona. Leptina. Adiponectina. ABSTRACTObesity is a chronic disease, considered to be an important risk factor in the development of coronary disease, hypertension, renal insufficiency and failure.Obesity contributes to hypertension by mechanisms such as: insulinic resistance and hyperinsulinaemia, increase of adrenergic activity and of concentrations of aldosterone, retention of sodium and water and increase of cardiac wear, alteration of the endothelial function, through molecules such as leptin and adiponectin and genetic factors. Many paths of research remain open.The angiotensin-converting-enzyme inhibitors (ACEI) and/or the angiotensin II receptor antagonists (ARA II) are first choice medicines because of their beneficial effect on insulinic resistance and sympathetic activity.

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Transforming growth factor-β1 levels in hypertensive patients: association with body mass index and leptin1

Abstract: Our data indicate that TGF-beta1 levels are positively associated with BMI and leptin levels in hypertensive patients and suggest that adipose tissue may be an important determinant of TGF-beta1 levels possibly by a leptin-dependent pathway.

Cited by 49 publications

References 31 publications

Left ventricular filling abnormalities and obesity-associated hypertension: relationship with overproduction of circulating transforming growth factor β1

Left ventricular filling abnormalities and obesity-associated hypertension: relationship with overproduction of circulating transforming growth factor β1

<b>The Relationship Between Obesity and Transforming Growth Factor Beta on Renal Damage in Essential Hypertension</b>

Mecanismos de hipertensión en obesidad

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