2004
DOI: 10.1097/01.ccm.0000104951.94820.a9
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Transfusion-related leukocytosis in critically ill patients*

Abstract: Transfusion of non-filtered packed red cells, but not of pre-storage-filtered packed red cells, may frequently cause an acute and transient leukocytosis in critically ill nonseptic patients. Interleukin-8 accumulating in stored non-filtered packed red cells may play a role in this phenomenon. Recognition of post packed red cell transfusion leukocytosis may avoid unnecessary investigations and therapies in false suspicion of sepsis.

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Cited by 45 publications
(51 citation statements)
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“…Repletion of SNO-Hb levels during storage improved the vasodilatory function of RBCs in vivo (41). Reduction of the white blood cell content of stored blood (leukodepletion) also may contribute to improvements in RBC function and decrease the content of cytokines and inflammatory mediators in stored blood (61)(62)(63)(64). The immune response to TRIM is attenuated by leukodepletion of blood products before transfusion, suggesting that either a component or byproduct of donor leukocytes elicits the recipient response (65).…”
Section: Mechanisms Linking Blood Transfusion With Excess Mortalitymentioning
confidence: 91%
“…Repletion of SNO-Hb levels during storage improved the vasodilatory function of RBCs in vivo (41). Reduction of the white blood cell content of stored blood (leukodepletion) also may contribute to improvements in RBC function and decrease the content of cytokines and inflammatory mediators in stored blood (61)(62)(63)(64). The immune response to TRIM is attenuated by leukodepletion of blood products before transfusion, suggesting that either a component or byproduct of donor leukocytes elicits the recipient response (65).…”
Section: Mechanisms Linking Blood Transfusion With Excess Mortalitymentioning
confidence: 91%
“…Although transfusion of blood products is often a life‐saving measure, this procedure is not without risk. Administration of RBC transfusions has been associated with inflammation . Such inflammatory responses following blood transfusion could negatively impact patient outcome.…”
Section: Introductionmentioning
confidence: 99%
“…These are most commonly seen with type B cats (having strong anti-A antibodies) inadvertently getting type A blood. [12][13][14] During storage of whole blood or pRBCs, contaminating leukocytes undergo lysis, which releases immunomodulators such as histamine, myeloperoxidase, plasminogen activator inhibitor 1, and eosinophilic cationic protein. 11 Because many of our critically ill transfusion recipients have concomitant clinical signs similar to transfusion reactions, it is possible that we are underestimating a more common reaction.…”
Section: Severe Transfusion Reactions In Felinesmentioning
confidence: 99%