Transfusion‐transmitted anaplasmosis from a leukoreduced platelet pool

Abstract

This is the first confirmed case of TTA from a whole blood-derived PLT pool prepared from PLT concentrates leukoreduced by in-line filtration of PLT-rich plasma.

Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis — United States

“…Transmission of A. phagocytophilum despite leukoreduction of red blood cells and platelets has occurred (227,228,231,232). Transmission of E. ewingii infection via leukoreduced, irradiated platelet transfusion also has been reported (233).…”

“…Transmission of E. ewingii infection via leukoreduced, irradiated platelet transfusion also has been reported (233). Although the risk for transmission of certain rickettsial pathogens might be reduced by leukoreduction of blood products (234), the risk for transfusion-acquired infection is not eliminated (227,228,231,233,235). In vitro studies demonstrate that A. phagocytophilum and E. chaffeensis survive in refrigerated packed erythrocytes for up to 18 and 11 days, respectively (236,237).…”

“…Among tickborne rickettsial diseases, anaplasmosis is the most frequently associated with transfusion-acquired infection, with eight published reports from the United States (198,(227)(228)(229)(230)(231)(232). Transmission of A. phagocytophilum despite leukoreduction of red blood cells and platelets has occurred (227,228,231,232).…”

Molecular characterization of Anaplasma and Ehrlichia in ixodid ticks and reservoir hosts from Palestine: a pilot survey

“…Hard ticks from the Ixodidae family usually transmit these pathogens to mammals; in addition, they can be transmitted directly to both human and animals by blood transfusion (Fine et al . ; Marenzoni et al . ).…”

“…The reservoir hosts include numerous wild and domesticated animals (Dumler et al 2001;Ismail et al 2010). Hard ticks from the Ixodidae family usually transmit these pathogens to mammals; in addition, they can be transmitted directly to both human and animals by blood transfusion (Fine et al 2016;Marenzoni et al 2017). The genus Ehrlichia contains six recognized species: Ehrlichia canis, E. chaffeensis, E. ewingii, E. muris, E. ruminantium and E. minasensis (Cabezas-Cruz et al 2016).…”