Transgenic mouse models of dopamine deficiency

Chen, Linan; Zhuang, Xiaoxi

doi:10.1002/ana.10655

Cited by 20 publications

(16 citation statements)

References 105 publications

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“…DRD2, mRNA however, when knocked-out, has been shown to reduce fertility greatly (Chen and Zhuang 2003). Gevry et al (2006) had found elevated levels of the long and short forms of the DRD2 in Npc1 -/-mice, using a semi-quantitative method, while we found mildly decreased levels of total receptor using a quantitative method.…”

Section: Discussionmentioning

confidence: 48%

Expression ofNpc1 in Glial Cells Corrects Sterility inNpc1 -/- mice

2009

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Niemann-Pick type C1 (NPC) disease is an autosomal recessive neurodegenerative disorder. One feature of the mouse model of NPC1 is it's infertility. We have made transgenic mice which express the Npc1 protein exclusively in fibrillary astrocytes, using the glial fibrillary acidic protein (GFAP) promoter. This selective expression of Npc1 corrects sterility in GFAP-Npc1(-/-), Npc1(-/-) mice. Counts of acidophils in the pituitary of GFAP-Npc1E, Npc1(-/-) mice, as compared Npc1(-/-) mice, and measurements of dopamine D2 receptor (DRD2) mRNA in the pituitary, suggest mechanisms for fertility enhancement. We conclude that the correction of sterility in GFAP-Npc1E, Npc1(-/-) mice is a result of restoring hypothalamic control of the pituitary.

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Section: Discussionmentioning

confidence: 48%

Expression ofNpc1 in Glial Cells Corrects Sterility inNpc1 -/- mice

2009

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“…The process of neurotransmission, however, requires other steps including storage in presynaptic nerve vesicles, release, interaction with receptors, and reuptake. In most animal models where each of these steps has been knocked out, the intracellular (and presumably extracellular) concentrations of neurotransmitters are profoundly changed (67)(68)(69)(70)(71). It is certain that these disorders occur in humans.…”

Section: Discussionmentioning

confidence: 99%

Clinical Utility of Monoamine Neurotransmitter Metabolite Analysis in Cerebrospinal Fluid

Hyland

2008

Clinical Chemistry

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BACKGROUND:Measurements of monoamine neurotransmitters and their metabolites in plasma and urine are commonly used to aid in the detection and monitoring of neuroblastoma and pheochromocytoma and the evaluation of hypotension or hypertension. Measurements of these neurotransmitters and metabolites can also be helpful in the investigation of disorders that primarily affect the central nervous system, but only when the measurements are made in cerebrospinal fluid (CSF).CONTENT: I describe CSF profiles of monoamine metabolites in the primary and secondary defects affecting serotonin and catecholamine metabolism. I outline the methods required to analyze these metabolites together with details of specific sample handling requirements, sample stability, and interfering compounds, and I emphasize a need for age-related reference intervals.

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“…Antidopamin adalah bahan kimia yang dapat menghentikan kerja dopamin (prolactin-inhibiting factor, prolactin-inhibiting hormone, prolactostatin) yaitu neurotransmitter yang berperan dalam menghambat pematangan gonad udang (Chen & Zhuang, 2003) dan menghambat pelepasan prolaktin pada mamalia. Aplikasi kombinasi GTH dan AD sebagai pengganti ablasi pada udang windu alam perlu dilakukan untuk mengetahui efek hormon ini terhadap pematangan dan produksi naupli.…”

Section: Pendahuluanunclassified

INDUKSI PEMATANGAN GONAD DAN PENINGKATAN TINGKAT PEMBUAHAN TELUR INDUK UDANG WINDU, Penaeus monodon MELALUI RANGSANGAN HORMONAL TANPA ABLASI MATA

Laining

Lante

Usman

2015

Jurnal Riset Akuakultur

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ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh rangsangan hormon gonadotropin (GTH) dan antidopamin (AD) terhadap performa induk betina alam sebagai pengganti ablasi. Dua perlakuan yang dicobakan adalah: 1) rangsangan hormon GTH dan AD pada betina udang windu alam tanpa ablasi; 2) kontrol berupa ablasi induk udang windu tanpa rangsangan hormon. Hasil yang diperoleh menunjukkan bahwa pemijahan pertama terjadi setelah rangsangan ke-2 yaitu 4 ekor induk (23,5%). Pascainjeksi ke-3, jumlah induk yang memijah meningkat menjadi 92,7% atau sebanyak 11 ekor dari 12 ekor yang diinjeksi. Setelah empat kali rangsangan, dari 17 ekor yang diinjeksi ternyata 14 ekor dapat memijah (82%) dan 3 ekor induk tidak memijah hingga akhir pengamatan. Kontrol menghasilkan 6 ekor induk memijah dari 10 ekor yang diablasi (60%). Fekunditas telur (fertil dan tidak fertil) dari induk yang dirangsang GTH+AD adalah 219.313 butir/induk lebih tinggi dibandingkan induk yang diablasi yaitu 182.848 butir/induk. Tingkat pembuahan pada kontrol adalah 54%, lebih rendah jika dibandingkan dengan jumlah telur yang fertil dari induk yang dirangsang GTH+AD yaitu 76%. Meskipun tingkat pembuahan telur yang dihasilkan oleh induk pascainjeksi lebih tinggi, ternyata tingkat penetasan telurnya hanya 39%, lebih rendah dari induk yang diablasi yaitu 52%. Diameter telur dari induk yang mendapat rangsangan AD+GTH adalah 29,3 μm ± 0,8 (rerata ± SD) lebih besar dari diameter telur induk yang diablasi (25,1 μm ± 0,3). Total asam amino karkas induk udang yang dirangsang GTH+AD adalah 61,4% relatif lebih tinggi dibandingkan kontrol. Berdasarkan jumlah induk yang matang gonad dan fekunditas telur yang dihasilkan, aplikasi AD+GTH secara injeksi cukup dilakukan 3x pada dosis 0,3 mL/100 g udang. KATA KUNCI: domestikasi, udang windu, gonadotropin, antidopamin ABSTRACT:Induce of gonadal maturation and improvement of egg fertilization rate of female broodstock tiger shrimp, Penaeus monodon through hormonal induction without eyed ablation. By: Asda Laining, Samuel Lante, and Usman The aim of this experiment was to determine the influence of induction of gonadotrophine hormone (GTH) combined with dopamine antagonist (AD) on reproductive performances of wild female tiger shrimp to replace eyed ablation. Two treatments were investigated namely 1) induction of GTH and AD to female without eye ablation

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Transgenic mouse models of dopamine deficiency

Cited by 20 publications

References 105 publications

Expression ofNpc1 in Glial Cells Corrects Sterility inNpc1 -/- mice

Expression ofNpc1 in Glial Cells Corrects Sterility inNpc1 -/- mice

Clinical Utility of Monoamine Neurotransmitter Metabolite Analysis in Cerebrospinal Fluid

INDUKSI PEMATANGAN GONAD DAN PENINGKATAN TINGKAT PEMBUAHAN TELUR INDUK UDANG WINDU, Penaeus monodon MELALUI RANGSANGAN HORMONAL TANPA ABLASI MATA

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