Transglucosidase improves the bowel movements in type 2 diabetes mellitus patients: A preliminary randomized double‐blind, placebo‐controlled study

Shimozato, Akihiro; Sasaki, Makoto; Ogasawara, Nagahisa; Funaki, Yasushi; Ebi, Masahide; Goto, Chiho; Koikeda, Satoshi; Joh, Takashi; Kasugai, Kunio

doi:10.1177/2050640617692268

Cited by 11 publications

(8 citation statements)

References 25 publications

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“…Caulobacteraceae was characterized as the microorganism responsible for decomposing cellulose in ecosystems 34 . Clostridium XVIII was proved to be increased in the patients with bowel movement disorder 35 , highlighting a negative role of this bacterium in the regulation of gut health. The genus Vampirovibrio and class Deltaproteobacteria were highly enriched in gut of infected chickens, and associated with intestinal inflammation and injury 36 , 37 .…”

Section: Discussionmentioning

confidence: 99%

Supplemental Bacillus subtilis DSM 32315 manipulates intestinal structure and microbial composition in broiler chickens

Wang

Zhang

et al. 2018

Sci Rep

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Knowledge about the modulation of gut microbiota improves our understanding of the underlying mechanism by which probiotic treatment benefits the chickens. This study examined the effects of Bacillus subtilis DSM 32315 on intestinal structure and microbial composition in broilers. Broiler chicks were fed basal diets without or with B. subtilis supplementation (1.0 × 109 spores/kg of diet). Supplemental B. subtilis increased average body weight and average daily gain, as well as elevated villus height and villus height to crypt depth ratio of ileum in broilers. Multi-dimension analysis showed a certain degree of separation between the cecal microbiota from treatment and control groups. Increased Firmicutes abundance and reduced Bacteroidetes abundance in cecum were observed responded to B. subtilis addition, which also increased the abundances of Christensenellaceae and Caulobacteraceae, and simultaneously decreased the abundances of potentially harmful bacteria such as Vampirovibrio, Escherichia/Shigella and Parabacteroides. Network analysis signified that B. subtilis addition improved the interaction pattern within cecal microbiota of broilers, however, it exerted little influence on the metabolic pathways of cecal microbiota by comparison of the functional prediction of metagenomes. In conclusion, supplemental B. subtilis DSM 32315 improved growth performance and intestinal structure of broilers, which could be at least partially responsible by the manipulation of cecal microbial composition.

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Section: Discussionmentioning

confidence: 99%

Supplemental Bacillus subtilis DSM 32315 manipulates intestinal structure and microbial composition in broiler chickens

Wang

Zhang

et al. 2018

Sci Rep

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“…Shimozato et al observed that TGD administration to patients with T2D for 12 weeks significantly affected the fecal microbiota content, increasing Clostridium cluster IV, Clostridium subcluster XIVa, Clostridium cluster XVIII, and fecal pH and decreasing the order Lactobacillales in patients with bowel movement disorder compared with the controls. The TGD treatment significantly improved bowel movements compared with the placebo treatment, and this effect was not observed in patients without bowel movement disorder [161].…”

Section: Gut Microbiota Changes In Particular Pathologiesmentioning

confidence: 99%

Microbial Population Changes and Their Relationship with Human Health and Disease

et al. 2019

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Specific microbial profiles and changes in intestinal microbiota have been widely demonstrated to be associated with the pathogenesis of a number of extra-intestinal (obesity and metabolic syndrome) and intestinal (inflammatory bowel disease) diseases as well as other metabolic disorders, such as non-alcoholic fatty liver disease and type 2 diabetes. Thus, maintaining a healthy gut ecosystem could aid in avoiding the early onset and development of these diseases. Furthermore, it is mandatory to evaluate the alterations in the microbiota associated with pathophysiological conditions and how to counteract them to restore intestinal homeostasis. This review highlights and critically discusses recent literature focused on identifying changes in and developing gut microbiota-targeted interventions (probiotics, prebiotics, diet, and fecal microbiota transplantation, among others) for the above-mentioned pathologies. We also discuss future directions and promising approaches to counteract unhealthy alterations in the gut microbiota. Altogether, we conclude that research in this field is currently in its infancy, which may be due to the large number of factors that can elicit such alterations, the variety of related pathologies, and the heterogeneity of the population involved. Further research on the effects of probiotics, prebiotics, or fecal transplantations on the composition of the human gut microbiome is necessary.

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“…86 Finally, the enzyme transglucosidase (used as a dietary supplement) changes the gut microbiome and increases the weekly number of bowel movements in people with type 2 diabetes and constipation. 87…”

Section: Managementmentioning

confidence: 99%

Pathophysiology and management of diabetic gastroenteropathy

Meldgaard

Keller

Olesen

et al. 2019

Therap Adv Gastroenterol

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Polyneuropathy is a common complication to diabetes. Neuropathies within the enteric nervous system are associated with gastroenteropathy and marked symptoms that severely reduce quality of life. Symptoms are pleomorphic but include nausea, vomiting, dysphagia, dyspepsia, pain, bloating, diarrhoea, constipation and faecal incontinence. The aims of this review are fourfold. First, to provide a summary of the pathophysiology underlying diabetic gastroenteropathy. Secondly to give an overview of the diagnostic methods. Thirdly, to provide clinicians with a focussed overview of current and future methods for pharmacological and nonpharmacological treatment modalities. Pharmacological management is categorised according to symptoms arising from the upper or lower gut as well as sensory dysfunctions. Dietary management is central to improvement of symptoms and is discussed in detail, and neuromodulatory treatment modalities and other emerging management strategies for diabetic gastroenteropathy are discussed. Finally, we propose a diagnostic/investigation algorithm that can be used to support multidisciplinary management.

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Transglucosidase improves the bowel movements in type 2 diabetes mellitus patients: A preliminary randomized double‐blind, placebo‐controlled study

Cited by 11 publications

References 25 publications

Supplemental Bacillus subtilis DSM 32315 manipulates intestinal structure and microbial composition in broiler chickens

Supplemental Bacillus subtilis DSM 32315 manipulates intestinal structure and microbial composition in broiler chickens

Microbial Population Changes and Their Relationship with Human Health and Disease

Pathophysiology and management of diabetic gastroenteropathy

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