Transglutaminase II/MicroRNA-218/-181a Loop Regulates Positive Feedback Relationship between Allergic Inflammation and Tumor Metastasis

Eom, Sangkyung; Kim, Youngmi; Kim, Mi-Sun; Park, Deokbum; Lee, Hansoo; Lee, Yun Sil; Choe, Jongseon; Kim, Young Myeong; Jeoung, Dooil

doi:10.1074/jbc.m114.603480

Cited by 24 publications

(33 citation statements)

References 56 publications

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“…Monitoring of Rectal Temperature-Changes in core body temperature associated with systemic anaphylaxis were monitored by measuring changes in rectal temperatures using a rectal probe coupled to a digital thermometer as described (9,10).…”

Section: Methodsmentioning

confidence: 99%

“…␤-Hexosaminidase Activity Assays-The ␤-hexosaminidase activity assay was performed according to standard procedures (9).…”

Section: Methodsmentioning

confidence: 99%

“…miR-26a Mimic and miR-26b Mimic Negatively Regulate Allergic Inflammation-promoted Enhanced Tumorigenic Potential-PSA enhances the tumorigenic potential of cancer cells (9,10). PSA enhanced the tumorigenic potential of mouse melanoma B16F1 cells less than malignant melanoma cells (Figs.…”

Section: Mir-26a Mimic and Mir-26b Mimic Negatively Regulate Thementioning

confidence: 99%

“…HDAC3 mediates allergic inflammation by regulating the expression of MCP1 (28). TGaseII forms a feedback loop with miR-218/-181a and regulates allergic inflammation in vitro and in vivo (9). COX-2 expression is regulated by histone modifications (29).…”

Section: Cox-2 Is Necessary For In Vivo Allergicmentioning

confidence: 99%

“…PSA forms a positive feedback relationship with tumorigenesis (9,10). These bioactive mediators cause severe hypotension, decrease in body temperature, and increased ␤-hexosaminidase activity (11).…”

mentioning

confidence: 99%

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MicroRNA-26a/-26b-COX-2-MIP-2 Loop Regulates Allergic Inflammation and Allergic Inflammation-promoted Enhanced Tumorigenic and Metastatic Potential of Cancer Cells

Kwon

Kim

Eom

et al. 2015

Journal of Biological Chemistry

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Background:The molecular mechanism of COX-2-mediated allergic inflammation remains unknown. Results: miR-26a/-26b target COX-2 and regulate allergic inflammation-promoted enhanced tumorigenic and metastatic potential of cancer cells. Conclusion:The miR-26a/-26b-COX-2-MIP-2 loop regulates a positive feedback between allergic inflammation and tumor metastasis. Significance: The miR-26a/-26b-COX-2-MIP-2 loop can be employed for the development of anti-allergy and anti-cancer drugs.

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Section: Methodsmentioning

confidence: 99%

“…␤-Hexosaminidase Activity Assays-The ␤-hexosaminidase activity assay was performed according to standard procedures (9).…”

Section: Methodsmentioning

confidence: 99%

Section: Mir-26a Mimic and Mir-26b Mimic Negatively Regulate Thementioning

confidence: 99%

Section: Cox-2 Is Necessary For In Vivo Allergicmentioning

confidence: 99%

mentioning

confidence: 99%

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MicroRNA-26a/-26b-COX-2-MIP-2 Loop Regulates Allergic Inflammation and Allergic Inflammation-promoted Enhanced Tumorigenic and Metastatic Potential of Cancer Cells

Kwon

Kim

Eom

et al. 2015

Journal of Biological Chemistry

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Lysophosphatidic acid receptor 4 regulates osteogenic and adipogenic differentiation of progenitor cells via inactivation of RhoA/ROCK1/β-catenin signaling

Xie

Wang

et al. 2019

Stem Cells

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Recent evidence revealed that lysophosphatidic acid receptor 4 (LPAR4) plays a role in osteogenesis and bone remodeling in mice. However, the molecular mechanism by which LPAR4 controls osteogenic and adipogenic differentiation of mesenchymal progenitor cells remains pending. In the current study, our data showed that Lpar4 was expressed in bone and adipose tissue and the expression increased during osteoblast and adipocyte differentiation. Lpar4 overexpression in stromal ST2 and preosteoblastic MC3T3‐E1 cells inhibited osteogenic differentiation. By contrast, Lpar4 overexpression in ST2 and mesenchymal C3H10T1/2 cells enhanced adipogenic differentiation. Conversely, depletion of endogenous Lpar4 in the progenitor cells induced osteogenic differentiation and inhibited adipogenic differentiation. Furthermore, enhanced osteoblast differentiation and alleviated fat accumulation were observed in marrow of mice after in vivo transfection of Lpar4 siRNA. Mechanism investigations revealed that LPAR4 inhibited the activation of ras homolog family member A (RhoA)/Rho‐associated kinases 1 (ROCK1) and canonical Wnt signal pathways. ROCK1 was shown to be able to activate Wnt/β‐catenin pathway. We further demonstrated that the overexpression of ROCK1 stimulated osteogenic differentiation and restrained adipogenic differentiation from stromal progenitor cells. Moreover, overexpression of ROCK1 attenuated the inhibition of osteogenic differentiation by LPAR4. The current study has provided evidences demonstrating that RhoA/ROCK1 activates β‐catenin signaling to promote osteogenic differentiation and conversely restrain adipogenic differentiation. The inactivation of RhoA/ROCK1/β‐catenin signaling is involved in LPAR4 regulation of the directional differentiation of marrow stromal progenitor cells.

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A long non-coding RNA inside the type 2 transglutaminase gene tightly correlates with the expression of its transcriptional variants

et al. 2018

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The long non-coding RNAs (lncRNAs) are matter of intense investigation as potential regulators of gene expression. In the case of the transglutaminase 2 gene (TGM2) the databases of genome sequence indicate location of a lncRNA (LOC107987281) within the first intron. This lncRNA is 1000 bp long, arises from 2 exons and starts few nucleotides 3' of the first splicing site of translated TGM2. We have analysed correlations between expression of LOC107987281 lncRNA and TGM2 mRNA by real-time PCR in K562 cell line untreated or treated with the anticancer drugs TPA (12-O-tetradecanoylphorbol-13-acetate), Docetaxel and Doxorubicin. In the treated cells the lncRNA increase follows the trend of TGM2 transcript. To validate this finding we used HumanExon1_0ST Affymetrix; chip data were background-adjusted, quantile-normalized and summarized using robust multi-array average analysis implemented in the R package. The probesets recognize sequences inside each exon, near intronic splicing sites and others located in the untranslated regions of TGM2 gene. The analysis of total RNA samples in GEO datasets from K562, HL-60, THP-1 and U937 cell lines, untreated or treated with TPA in replicated experiments confirmed our earlier results. These demonstrate correlation between LOC107987281 and TGM2 mRNA in the cell lines (K562, HL60 and THP-1) where increased levels of TGM2 mRNA are produced. Additional array study on 358 samples of several normal and paired tumor tissues leads to the same conclusions, indicating a correlation between full-length TGM2 mRNA and LOC107987281 lncRNA in relation to the development of several tumors.

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Transglutaminase II/MicroRNA-218/-181a Loop Regulates Positive Feedback Relationship between Allergic Inflammation and Tumor Metastasis

Cited by 24 publications

References 56 publications

MicroRNA-26a/-26b-COX-2-MIP-2 Loop Regulates Allergic Inflammation and Allergic Inflammation-promoted Enhanced Tumorigenic and Metastatic Potential of Cancer Cells

MicroRNA-26a/-26b-COX-2-MIP-2 Loop Regulates Allergic Inflammation and Allergic Inflammation-promoted Enhanced Tumorigenic and Metastatic Potential of Cancer Cells

Lysophosphatidic acid receptor 4 regulates osteogenic and adipogenic differentiation of progenitor cells via inactivation of RhoA/ROCK1/β-catenin signaling

A long non-coding RNA inside the type 2 transglutaminase gene tightly correlates with the expression of its transcriptional variants

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