2008
DOI: 10.3346/jkms.2008.23.1.138
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Transient Acquired Hemophilia Associated with Mycoplasma Pneumoniae Pneumonia

Abstract: Acquired hemophilia is a rare disorder caused by autoantibodies to factor VIII (FVIII) (also referred to as factor VIII inhibitors or anti-FVIII) and may be associated with pregnancy, underlying malignancy, or autoimmune disorders. A 33-month-old girl who presented with hematochezia and ecchymotic skin lesions was diagnosed with Mycoplasma pneumoniae pneumonia by serology and polymerase chain reaction. Hematologic studies showed a prolonged activated partial thromboplastin time (aPTT), partially corrected mixi… Show more

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Cited by 14 publications
(4 citation statements)
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“…In several reports, MP infection transiently influenced the activity of many coagulation factors, including II, VIII, or X. [ 38 ] One possible mechanism behind this phenomenon is the consumptive coagulopathy due to hepatic deterioration. As a main inhibitor of thrombin, antithrombin III plays a protective role in the coagulation system.…”
Section: Discussionmentioning
confidence: 99%
“…In several reports, MP infection transiently influenced the activity of many coagulation factors, including II, VIII, or X. [ 38 ] One possible mechanism behind this phenomenon is the consumptive coagulopathy due to hepatic deterioration. As a main inhibitor of thrombin, antithrombin III plays a protective role in the coagulation system.…”
Section: Discussionmentioning
confidence: 99%
“…There have been a couple of published reports on AHA in Korea, in associated with Mycoplasma pneumoniae infection and Cobra toxin intake ( 19 , 20 ). However, this is the first report on postpartum AHA in Korea.…”
Section: Discussionmentioning
confidence: 99%
“…자가면역성 질환(전신홍반루푸스, 류마티스관절염 등), 악성종양, 임신 (대부분 첫 번째 임신에서 발생하며, 출산 후 1-4개월에 발생함. 자가항체 가 태반을 통과하므로 태아에 출혈 위험이 있음), 5,6 감염, 7 약제 등 후천성 혈우병 A 발생에 관련된 원인이 있는 경우가 50% 정도 되며, 나머지 50% 에서는 원인불명(idiopathic)으로 밝혀진 관련된 질환 없이 발생하는 것으 로 알려져 있다. 1,8 비록 약 30% 정도에서는 출혈이 심하지 않아 출혈에 대 한 지혈치료가 필요 없으나, 최근의 대규모 보고에 따르면 94.6%에서는 출 혈성 임상양상이 동반되었고, 77%의 자연출혈과 70%의 심각한 출혈(혈 색소 < 8 g/dL 또는 혈색소 >2 g/dL 감소로 정의됨)이 관찰되었다.…”
Section: 서론unclassified