Transient apical pseudohypertophy due to myocardial edema in patients with Takotsubo syndrome

Madias, John E.

doi:10.1016/j.hrtlng.2015.09.002

Cited by 5 publications

(2 citation statements)

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“…In humans, catecholamines may cause toxic myocarditis in cases of phaeocromocytoma or stress‐induced (Takotsubo) cardiomyopathy due to an exaggerated sympathetic stimulation . Takotsubo cardiomyopathy is a transient left ventricular dysfunction most frequently characterized by an apical “ballooning” phenotype in people, but myocardial edema mimicking HCM has also been described in Takotsubo cases, and differentiation from true HCM requires advanced cross‐sectional imaging . TMT could then potentially be caused by an emotional or physical stress associated with the reported antecedent events.…”

Section: Discussionmentioning

confidence: 99%

“…As reverse remodeling with normalization of cardiac structure and function is not an expected outcome in HCM, these clinical observations describe a transient form of myocardial thickening associated with CHF in cats. Transient myocardial thickening (TMT) mimicking HCM has been described in some forms of acute/fulminant myocarditis in humans and in atypical cases of stress‐induced (Takotsubo) cardiomyopathy . In both situations, the increased LVWT is associated with myocardial edema …”

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confidence: 99%

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Transient Myocardial Thickening in Cats Associated with Heart Failure

Matos

Pereira

Glaus

et al. 2017

Veterinary Internal Medicne

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BackgroundCats with hypertrophic cardiomyopathy (HCM) and congestive heart failure (CHF) can have resolution of both left ventricular hypertrophy and CHF.ObjectivesTo describe the clinical characteristics of cats with transient myocardial thickening (TMT) and CHF compared with a control population of cats without resolution of HCM.AnimalsA total of 21 cats with TMT, 21 cats with HCM.MethodsRetrospective study. Clinical records at 4 veterinary centers were searched for TMT cases and a control group of cats with HCM and CHF. TMT was defined as initial maximal left ventricular wall thickness (LVWT) ≥6 mm with left‐sided CHF, with subsequent resolution of CHF, reduction in left atrium/aorta (LA/Ao), and LVWT<5.5 mm. HCM was defined as persistent LVWT ≥6 mm.ResultsCats with TMT were younger (2 [0.4–11.4] years) than cats with HCM (8 [1.6–14] years) (P < 0.0001), and antecedent events were more common (15/21 versus 6/21, respectively) (P = 0.01). In cats with TMT, LVWT normalized from 6.8 [6.0–9.7] mm to 4.8 [2.8–5.3] mm and LA/Ao decreased from 1.8 [1.6–2.3] to 1.45 [1.2–1.7] after a mean interval of 3.3 (95% CI: 1.8–4.7) months. CHF recurred in 1 of 21 TMT and 15 of 21 cats with HCM. Cardiac treatment was discontinued in 20 of 21 cats with TMT and 0 of 21 HCM cats. All cats with TMT survived, whereas 8 of 19 cats with HCM died during the study period.Conclusions and Clinical ImportanceTMT occurs in younger cats, and antecedent events are common. The prognosis is better in cats with CHF associated with TMT than HCM.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%