Transient expression of c-Fos in rat amygdala during training is required for encoding conditioned taste aversion memory.

Lamprecht, Raphael; Dudai, Yadin

doi:10.1101/lm.3.1.31

Cited by 136 publications

(107 citation statements)

References 43 publications

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“…However, neither behavioral effects nor signs of structural damage were observed when amounts of c-fos AS-ODN comparable to those used in the present study were applied to the amygdala several days (i.e., with an interval that allows degradation of ODNs) before training or shortly before testing of rats in a conditioned taste aversion paradigm (Lamprecht and Dudai 1996). Similarly, in the present study no tissue damage additional to injuries caused by the insertion of cannulae was observed in ODN-treated versus saline-treated rats during determination of cannulae positions 5 days following intrahippocampal injections (data not shown).…”

Section: Discussionmentioning

confidence: 97%

Suppression of c-fos induction in rat brain impairs retention of a brightness discrimination reaction.

Grimm¹,

Schicknick²,

Riede³

et al. 1997

Learn. Mem.

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IntroductionRecently, the induction of transcription factor-encoding immediate-early genes such as c-fos was observed in distinct brain regions of rats trained to acquire a footshock-motivated brightness discrimination in a Y-maze. The functional relevance of inducible transcription factors for learning and memory formation is, however, not clear. To address this question in the present study, we have used a synthetic antisense phosphorothioate oligodeoxynucleotide to suppress in vivo the expression of c-fos in rat brain.

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Section: Discussionmentioning

confidence: 97%

Suppression of c-fos induction in rat brain impairs retention of a brightness discrimination reaction.

Grimm¹,

Schicknick²,

Riede³

et al. 1997

Learn. Mem.

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“…Although the neural mechanisms underlying the robust and long-lasting association of taste aversion and nausea have yet to be elucidated, several brain areas have been implicated, including the amygdala and cortex. It has been shown that protein synthesis and new gene expression in the central amygdala are required for CTA memory (Lamprecht and Dudai, 1996). Furthermore, several studies have indicated that the amygdala CREB is essential for long-term CTA memory or for the retrieval of already formed long-term memory (Lamprecht et al, 1997;Balschun et al, 2003;Josselyn et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Abnormal Long-Lasting Synaptic Plasticity and Cognition in Mice Lacking the Mental Retardation GenePak3

Meng¹,

Meng²,

Hanna³

et al. 2005

J. Neurosci.

177

166

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Mutations in the Pak3 gene lead to nonsyndromic mental retardation characterized by selective deficits in cognition. However, the underlying mechanisms are yet to be elucidated. We report here that the knock-out mice deficient in the expression of p21-activated kinase 3 (PAK3) exhibit significant abnormalities in synaptic plasticity, specifically hippocampal late-phase long-term potentiation, and deficiencies in learning and memory. A dramatic reduction in the active form of transcription factor cAMP-responsive element-binding protein in the knock-out mice implicates a novel signaling mechanism by which PAK3 and Rho signaling regulate synaptic function and cognition.

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“…S1] revealed robust induction of Arc mRNA in response to individual presentation of CS taste (0.5% saccharin solution) and US LiCl (0.15 M 15 ml/kg body weight, i.p.) in the insular cortex (IC) and basolateral nucleus of the amygdala (BLA), two regions believed to be involved in CTA acquisition (15)(16)(17)(18), leading us to focus on these regions for evidence of CS-US convergence.…”

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confidence: 99%

Visualizing stimulus convergence in amygdala neurons during associative learning

Barot

Kyono

Clark

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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A central feature of models of associative memory formation is the reliance on information convergence from pathways responsive to the conditioned stimulus (CS) and unconditioned stimulus (US). In particular, cells receiving coincident input are held to be critical for subsequent plasticity. Yet identification of neurons in the mammalian brain that respond to such coincident inputs during a learning event remains elusive. Here we use Arc cellular compartmental analysis of temporal gene transcription by fluorescence in situ hybridization (catFISH) to locate populations of neurons in the mammalian brain that respond to both the CS and US during training in a one-trial learning task, conditioned taste aversion (CTA). Individual neurons in the basolateral nucleus of the amygdala (BLA) responded to both the CS taste and US drug during conditioning. Coincident activation was not evident, however, when stimulus exposure was altered so as to be ineffective in promoting learning (backward conditioning, latent inhibition). Together, these data provide clear visualization of neurons in the mammalian brain receiving convergent information about the CS and US during acquisition of a learned association.Arc ͉ memory ͉ novelty ͉ plasticity ͉ taste aversion conditioning A central issue in behavioral neuroscience is how alterations in neural activity mediate the durable behavioral changes involved in learning. Current concepts of associative memory formation are based on the premise that plasticity relies on convergence of information from pathways responsive to the conditioned stimulus (CS) and the unconditioned stimulus (US) (1-3). Yet despite impressive progress in defining underlying neuronal circuitry and probable sites of association for several associative learning models (2, 4-6), identification of neuronal populations where convergent activation actually occurs during learning remains elusive. Electrophysiological studies have made inroads toward this goal, but are hampered by limited sampling ability, especially when the targets are convergent neurons, which are likely to be sparsely distributed during any single training trial. In those studies where convergent activation was recorded, animals were either anesthetized or had already reached asymptotic performance on a learning task (5-7).The imaging method known as cellular compartmental analysis of temporal gene transcription by fluorescence in situ hybridization (catFISH) can circumvent several of the technical limitations that have made it difficult to sample broad regions of the mammalian brain with high cellular and temporal resolution during a learning event (8). In particular, catFISH serves as a functional imager that allows investigators to distinguish neuronal populations activated by two distinct behavioral experiences. CatFISH utilizes Arc (or Arg 3.1), an immediate early gene (IEG) that is expressed in forebrain glutamatergic neurons after periods of enhanced activation (9, 10). The innovative features of catFISH rely on the time course of Arc mRNA locali...

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Transient expression of c-Fos in rat amygdala during training is required for encoding conditioned taste aversion memory.

Cited by 136 publications

References 43 publications

Suppression of c-fos induction in rat brain impairs retention of a brightness discrimination reaction.

Suppression of c-fos induction in rat brain impairs retention of a brightness discrimination reaction.

Abnormal Long-Lasting Synaptic Plasticity and Cognition in Mice Lacking the Mental Retardation GenePak3

Visualizing stimulus convergence in amygdala neurons during associative learning

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