Transient Fetal Tachycardia After Intravenous Diphenhydramine Administration

Abernathy, Alice; Alsina, Laura; Greer, Jessica; Egerman, Robert

doi:10.1097/aog.0000000000002147

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…Frontiers in Physiology | www.frontiersin.org (Kang et al, 2016) (Lau, 1995;Zhu et al, 2009) 300 (Kaplan et al, 2011;Wu et al, 2012;Upadhyaya et al, 2014;Chew et al, 2017) 1920 mg (27 mg/kg) >1000 (without First Pass Effect)* Diphenhydramine Antihistamine 14 30 (TC) QT interval prolongation, ventricular tachycardia, hemodynamic collapse, cardiac arrest, junctional rhythm, complete right bundle branch block, hypotension (Yu et al, 2016;Abernathy et al, 2017;Labarinas et al, 2018;Nishino et al, 2018) 18.7 mg/L 73 Antiemetic 4,10,13,14,16,20,30,31,39,43,46 3 (TC) Contraction band necrosis (post mortem), hypotension, arrhythmia, including QT interval prolongation, T wave change, U wave appearance, AV block, bundle branch block, ventricular premature contraction, ventricular tachycardia and ventricular fibrillation (Wasserman et al, 1975;Yang and Deng, 1998;Zhang et al, 2015) 45 mg/L 145 Erythromycin Antibiotic 10 300 (TC) QT interval prolongation, torsades de pointes tachycardia, 68% increased of hospital-acquired cardiac events (arrhythmia, heart failure, myocardial ischemia) (Giudicessi et al, 2018;Postma et al, 2019) 1300 mg (65 kg human, 15-20 mg/kg i.v. every 6 h) >300* Ethylhydrocupreine Antibiotic 14 10 (TC) ---Famotidine Antacid 10, 31 300 (TC) Cardiac arrest, third degree heart block, decreased stroke volume and cardiac output (Kirch et al, 1989;Schoenwald et al, 1999;Lee et al, 2004) 2x 20 mg i.v.…”

Section: Chloramphenicolmentioning

confidence: 99%

A Bitter Taste in Your Heart

2020

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The human genome contains ∼29 bitter taste receptors (T2Rs), which are responsible for detecting thousands of bitter ligands, including toxic and aversive compounds. This sentinel function varies between individuals and is underpinned by naturally occurring T2R polymorphisms, which have also been associated with disease. Recent studies have reported the expression of T2Rs and their downstream signaling components within non-gustatory tissues, including the heart. Though the precise role of T2Rs in the heart remains unclear, evidence points toward a role in cardiac contractility and overall vascular tone. In this review, we summarize the extra-oral expression of T2Rs, focusing on evidence for expression in heart; we speculate on the range of potential ligands that may activate them; we define the possible signaling pathways they activate; and we argue that their discovery in heart predicts an, as yet, unappreciated cardiac physiology.

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Section: Chloramphenicolmentioning

confidence: 99%

A Bitter Taste in Your Heart

2020

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“…Thus, histamine in the heart can stimulate histamine H 2 receptors unopposed, leading directly to a faster heart beat and more rapid atrioventricular node signal transduction [ 8 ]. In addition, some older antidepressant drugs (amitriptyline) and some antipsychotic drugs (haloperidol) are also potent histamine H 1 receptor antagonists, at least on receptors in transfected cells [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Function and Role of Histamine H1 Receptor in the Mammalian Heart

et al. 2023

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Histamine can change the force of cardiac contraction and alter the beating rate in mammals, including humans. However, striking species and regional differences have been observed. Depending on the species and the cardiac region (atrium versus ventricle) studied, the contractile, chronotropic, dromotropic, and bathmotropic effects of histamine vary. Histamine is present and is produced in the mammalian heart. Thus, histamine may exert autocrine or paracrine effects in the mammalian heart. Histamine uses at least four heptahelical receptors: H1, H2, H3 and H4. Depending on the species and region studied, cardiomyocytes express only histamine H1 or only histamine H2 receptors or both. These receptors are not necessarily functional concerning contractility. We have considerable knowledge of the cardiac expression and function of histamine H2 receptors. In contrast, we have a poor understanding of the cardiac role of the histamine H1 receptor. Therefore, we address the structure, signal transduction, and expressional regulation of the histamine H1 receptor with an eye on its cardiac role. We point out signal transduction and the role of the histamine H1 receptor in various animal species. This review aims to identify gaps in our knowledge of cardiac histamine H1 receptors. We highlight where the published research shows disagreements and requires a new approach. Moreover, we show that diseases alter the expression and functional effects of histamine H1 receptors in the heart. We found that antidepressive drugs and neuroleptic drugs might act as antagonists of cardiac histamine H1 receptors, and believe that histamine H1 receptors in the heart might be attractive targets for drug therapy. The authors believe that a better understanding of the role of histamine H1 receptors in the human heart might be clinically relevant for improving drug therapy.

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Diphenhydramine/fentanyl

2017

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Transient Fetal Tachycardia After Intravenous Diphenhydramine Administration

Abstract: Diphenhydramine may produce transient fetal tachycardia as well as increased maternal uterine activity.

Cited by 6 publications

References 4 publications

A Bitter Taste in Your Heart

A Bitter Taste in Your Heart

Function and Role of Histamine H1 Receptor in the Mammalian Heart

Diphenhydramine/fentanyl

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