Transient gestational diabetes insipidus: report of two cases and review of pathophysiology and treatment

El-Hennawy, Adel S; Bassi, T.; Koradia, N.; Bocirnea, A.

doi:10.1080/713606703

Cited by 3 publications

(5 citation statements)

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“…GDI is a self‐limiting condition that usually resolves within the first few weeks post‐partum. The treatment of choice is 1‐desamino‐8‐D‐arginine vasopressin (DDAVP), a synthetic analogue of vasopressin, which is resistant to degradation by vasopressinase, unlike ADH . DDAVP selectively activates the nonpressor V2 receptor, thus avoiding stimulation of blood pressure or uterine contractions, and is relatively long‐acting (12 h).…”

Section: Discussionmentioning

confidence: 99%

“…Gestational diabetes insipidus (GDI) complicates about 4 out of 100,000 pregnancies . This disorder is believed to be related to excess vasopressinase activity.…”

Section: Introductionmentioning

confidence: 99%

“…Gestational diabetes insipidus (GDI) complicates about 4 out of 100,000 pregnancies. 1 This disorder is believed to be related to excess vasopressinase activity. Liver dysfunction may be the trigger or a significant contributing factor for this complication.…”

Section: Introductionmentioning

confidence: 99%

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Acute presentation of gestational diabetes insipidus with pre‐eclampsia complicated by cerebral vasoconstriction: A case report and review of the published work

Mor

Fuchs

Zafra

et al. 2015

J of Obstet and Gynaecol

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Gestational diabetes insipidus (GDI) is a rare, self-limited complication of pregnancy. As it is related to excess placental vasopressinase enzyme activity, which is metabolized in the liver, GDI is more common in pregnancies complicated by conditions associated with liver dysfunction. We present a case of a 41-year-old woman at 38 weeks' gestation who presented with pre-eclampsia with severe features, including impaired liver function and renal insufficiency. Following cesarean section she was diagnosed with GDI, which was further complicated by cerebral vasoconstriction as demonstrated by magnetic resonance angiography. This case raises the possibility that cerebral vasoconstriction may be related to the cause of GDI. A high index of suspicion of GDI should be maintained in patients who present with typical signs and symptoms, especially in the setting of pregnancy complications associated with liver dysfunction.

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Section: Discussionmentioning

confidence: 99%

“…Gestational diabetes insipidus (GDI) complicates about 4 out of 100,000 pregnancies . This disorder is believed to be related to excess vasopressinase activity.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acute presentation of gestational diabetes insipidus with pre‐eclampsia complicated by cerebral vasoconstriction: A case report and review of the published work

Mor

Fuchs

Zafra

et al. 2015

J of Obstet and Gynaecol

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“…11 Some of these changes include an increase in cardiac output and glomerular filtration rate, sodium and water retention leading to blood volume expansion, chronic respiratory alkalosis, hyponatremia, and a reduction in systemic vascular resistance and blood pressure. They reach their peak during the second trimester, remain relatively stable during the third trimester, and rapidly reverse after delivery.…”

Section: Discussionmentioning

confidence: 99%

Transient Gestational Diabetes Insipidus

Alkaabi¹,

Thomas²,

Moussa³

2008

The Endocrinologist

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Our objective is to present a rare case of gestational diabetes insipidus (GDI) and review the literature to increase awareness. We describe a case of gestational diabetes insipidus, outline the details of the endocrine investigations, and discuss management.A 25-year-old woman, postcaesarian section, presented with polyuria, polydipsia, nausea, headache, loss of appetite, and occasional vomiting for 4 weeks. Physical examination, laboratory and radiographic findings were consistent with diabetes insipidus. She responded to removal of the placenta, desmopressin therapy, and appropriate fluid management. Literature review indicates GDI is rare. The precise pathophysiologic mechanism is uncertain.Clinicians should be aware of GDI to make an early diagnosis and initiate appropriate management. The main steps of the management include the removal of the placenta, the use of desmopressin, and close monitoring of fluid and electrolyte balance.

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“…Die Therapie der Wahl ist 1-Desamino-8-D-Arginin-Vasopressin (DDAVP), ein synthetisches Analogon von Vasopressin, das resistent auf den Abbau durch Vasopressinase ist [8]. Das DDAVP kann in mehreren Formen appliziert werden, aber die intranasale Applikation wirdwegen ihrer guten Dosierbarkeitam häufigsten genutzt, da eine DDAVP-Überdosierung leicht zu Hyponatriämie führen kann [7].…”

Section: Diskussionunclassified