Transient inhibition of mitochondrial function by chrysin and apigenin prolong longevity via mitohormesis in C. elegans

Cheng, Yu; Hou, Bing-Hao; Xie, Guangyuan; Shao, Ya-Ting; Yang, Jie; Xu, Chunjian

doi:10.1016/j.freeradbiomed.2023.03.264

Cited by 7 publications

(3 citation statements)

References 79 publications

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“…In a separate transgenic Drosophila model of Alzheimer’s disease (AD) expressing Amyloid Beta-42 in neurons and producing AD-like amyloid beta aggregates, a daily diet containing apigenin for 30 days was shown to delay the loss of climbing typically seen in this model ( 70 ). Apigenin similarly increases survival in a fly model of PD ( 54 ) and, in Caenorhabditis elegans , dietary supplementation with apigenin or apigenin glycosides increases lifespan ( 93 , 94 ).…”

Section: Apigenin and Agingmentioning

confidence: 99%

“…This, in turn, triggered a mitohormetic response which led to an overall increased capacity to deal with oxidative stress. Life extension also depended on the genes aak-2 , daf-16 , and skn-1 ( 94 ). Such findings are interesting given that, in a mouse model of myocardial injury, the protective effects of apigenin were dependent on the mitochondrial unfolded protein response ( 99 ).…”

Section: Apigenin and Agingmentioning

confidence: 99%

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Apigenin: a natural molecule at the intersection of sleep and aging

Kramer,

Johnson

2024

Front. Nutr.

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NAD+, a pivotal coenzyme central to metabolism, exhibits a characteristic decline with age. In mice, NAD+ levels can be elevated via treatment with apigenin, a natural flavonoid that inhibits the NAD+-consuming glycoprotein CD38. In animal models, apigenin positively impacts both sleep and longevity. For example, apigenin improves learning and memory in older mice, reduces tumor proliferation in a mouse xenograft model of triple-negative breast cancer, and induces sedative effects in mice and rats. Moreover, apigenin elongates survival in fly models of neurodegenerative disease and apigenin glycosides increase lifespan in worms. Apigenin’s therapeutic potential is underscored by human clinical studies using chamomile extract, which contains apigenin as an active ingredient. Collectively, chamomile extract has been reported to alleviate anxiety, improve mood, and relieve pain. Furthermore, dietary apigenin intake positively correlates with sleep quality in a large cohort of adults. Apigenin’s electron-rich flavonoid structure gives it strong bonding capacity to diverse molecular structures across receptors and enzymes. The effects of apigenin extend beyond CD38 inhibition, encompassing agonistic and antagonistic modulation of various targets, including GABA and inflammatory pathways. Cumulatively, a large body of evidence positions apigenin as a unique molecule capable of influencing both aging and sleep. Further studies are warranted to better understand apigenin’s nuanced mechanisms and clinical potential.

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Section: Apigenin and Agingmentioning

confidence: 99%

Section: Apigenin and Agingmentioning

confidence: 99%

Apigenin: a natural molecule at the intersection of sleep and aging

Kramer,

Johnson

2024

Front. Nutr.

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“…UPRmt genes are upregulated in Alzheimer’s disease (AD), PD, and other neurodegenerative diseases, suggesting a protective role against protein aggregation interfering with mitochondrial function [ 104 , 105 ]. Studies have shown that compounds like chrysanthemum and apigenin can inhibit mitochondrial respiration temporarily, induce early ROS production, and activate the AMPK/NRF-2/FOXO pathway, thereby promoting mitosis, enhancing oxidative stress capacity and cellular metabolic adaptation, and extending the lifespan of C. elegans [ 106 ]. These compounds delay aging and improve age-related diseases by targeting mitochondrial function, suggesting potential therapeutic strategies for mitigating neurodegeneration and aging-related decline.…”

Section: Mitochondrial Stress and Diseasementioning

confidence: 99%

Harnessing Mitochondrial Stress for Health and Disease: Opportunities and Challenges

Sun,

Jin,

Qin

et al. 2024

Biology

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Mitochondria, essential organelles orchestrating cellular metabolism, have emerged as central players in various disease pathologies. Recent research has shed light on mitohormesis, a concept proposing an adaptive response of mitochondria to minor disturbances in homeostasis, offering novel therapeutic avenues for mitochondria-related diseases. This comprehensive review explores the concept of mitohormesis, elucidating its induction mechanisms and occurrence. Intracellular molecules like reactive oxygen species (ROS), calcium, mitochondrial unfolded proteins (UPRmt), and integrated stress response (ISR), along with external factors such as hydrogen sulfide (H2S), physical stimuli, and exercise, play pivotal roles in regulating mitohormesis. Based on the available evidence, we elucidate how mitohormesis maintains mitochondrial homeostasis through mechanisms like mitochondrial quality control and mitophagy. Furthermore, the regulatory role of mitohormesis in mitochondria-related diseases is discussed. By envisioning future applications, this review underscores the significance of mitohormesis as a potential therapeutic target, paving the way for innovative interventions in disease management.

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Cellular oxidants and the proteostasis network: balance between activation and destruction

Ulfig,

Jakob

2024

Trends in Biochemical Sciences

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Transient inhibition of mitochondrial function by chrysin and apigenin prolong longevity via mitohormesis in C. elegans

Cited by 7 publications

References 79 publications

Apigenin: a natural molecule at the intersection of sleep and aging

Apigenin: a natural molecule at the intersection of sleep and aging

Harnessing Mitochondrial Stress for Health and Disease: Opportunities and Challenges

Cellular oxidants and the proteostasis network: balance between activation and destruction

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