Transient pseudothrombocytopenia in a neonate: Transmission of a maternal EDTA-dependent anticoagulant

Ohno, Norioki; Kobayashi, Masao; Hayakawa, Seiichi; Utsunomiya, Akari; Karakawa, Shuhei

doi:10.3109/09537104.2011.624210

Cited by 11 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Transplacental transmission of maternal IgG leading to PTCP in newborns has been described [53][54][55]. This condition should be considered in neonates with prolonged thrombocytopenia [56].…”

Section: Mechanisms Prevalence and Risk Factors 31 Mechanismsmentioning

confidence: 99%

Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications

Lardinois

Favresse

Châtelain

et al. 2021

JCM

View full text Add to dashboard Cite

Pseudothrombocytopenia (PTCP), a relative common finding in clinical laboratories, can lead to diagnostic errors, overtreatment, and further (even invasive) unnecessary testing. Clinical consequences with potential life-threatening events (e.g., unnecessary platelet transfusion, inappropriate treatment including splenectomy or corticosteroids) are still observed when PTCP is not readily detected. The phenomenon is even more complex when occurring with different anticoagulants. In this review we present a case of multi-anticoagulant PTCP, where we studied different parameters including temperature, amikacin supplementation, measurement methods, and type of anticoagulant. Prevalence, clinical risk factors, pre-analytical and analytical factors, along with clinical implications, will be discussed. The detection of an anticoagulant-dependent PTCP does not necessarily imply the presence of specific disorders. Conversely, the incidence of PTCP seems higher in patients receiving low molecular weight heparin, during hospitalization, or in men aged 50 years or older. New analytical technologies, such as fluorescence or optical platelet counting, will be soon overturning traditional algorithms and represent valuable diagnostic aids. A practical laboratory approach, based on current knowledge of PTCP, is finally proposed for overcoming spuriously low platelet counts.

show abstract

Section: Mechanisms Prevalence and Risk Factors 31 Mechanismsmentioning

confidence: 99%

Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications

Lardinois

Favresse

Châtelain

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…More importantly, transient EDTA-PTCP has been reported in only a few cases. [7–9] In this report, we outline a case of EDTA-PTCP that appeared transiently in a postoperative patient with sepsis.…”

Section: Introductionmentioning

confidence: 99%

Transient appearance of EDTA-dependent pseudothrombocytopenia in a postoperative patient with sepsis

Shi

Lin²,

He³

et al. 2017

Medicine

View full text Add to dashboard Cite

Rationale:Ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia (EDTA-PTCP) is a rare phenomenon characterized by spuriously low platelet counts when EDTA reacts with harvested blood. However, to the best of our knowledge, only two cases involving EDTA-PTCP in postoperative patients with sepsis have been reported. Here, we describe a case of EDTA-PTCP that appeared transiently in a postoperative patient with sepsis.Patient Concerns:A 68-year-old female patient underwent laparoscopic tension-free hernioplasty for incisional hernia. Postoperatively, the patient developed very low platelet counts. The number of platelets in this patient had not improved following treatment with fresh-frozen plasma and platelet transfusions.Diagnoses:The diagnosis of EDTA-PTCP was confirmed from the discovery of platelet aggregation in peripheral blood smears.Interventions:We used sodium citrate-anticoagulated blood samples for platelet counting.Outcomes:The patient's platelet counts returned to normal with the use of sodium citrate-anticoagulated blood samples. Furthermore, the phenomenon of EDTA-PTCP disappeared when the patient was cured.Lessons:The phenomenon of low platelet counts in postoperative patients with sepsis should be considered as possible EDTA-PTCP. In addition, peripheral blood smears and the use of sodium citrate anticoagulant are effective and valuable methods that can help identify EDTA-PTCP.

show abstract

Disorders of platelets and coagulation, thrombosis and blood transfusion

2022

Neonatal Haematology

View full text Add to dashboard Cite

Transient pseudothrombocytopenia in a neonate: Transmission of a maternal EDTA-dependent anticoagulant

Cited by 11 publications

References 6 publications

Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications

Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications

Transient appearance of EDTA-dependent pseudothrombocytopenia in a postoperative patient with sepsis

Disorders of platelets and coagulation, thrombosis and blood transfusion

Contact Info

Product

Resources

About