Transient Receptor Potential Channels

Islam, Md. Shahidul

doi:10.1007/978-94-007-0265-3

Cited by 41 publications

(11 citation statements)

References 1 publication

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“…These can be noticed in our phylogenetic tree as duplicated copies in mammals, sauropsids, amphibians, and chondrichthyans are recovered sister to each other within each organismal group. For example, the sister group relationship between the mammalian TRPV5 and TRPV6 gene lineages is maximally supported (100/1/100/1) ( Figure 1), reinforcing the hypothesis that the duplication event that gave rise to these copies occurred in the mammalian ancestor ( Figure 2), as previously suggested (Peng, 2011;Saito et al, 2011). Similarly, the sister group relationship between the sauropsid gene lineages is also well supported (86.5/1/82/1) ( Figure 1), indicating that a duplication event occurred in the sauropsid ancestor ( Figure 2).…”

Section: Amphibians and Chondrichthyanssupporting

confidence: 81%

“…A comparison of the genomic regions in chicken and crocodile showed remaining exons of the sauropsid TRPV6 gene in the genome of chicken ( Figure 3 -figure supplement 1). This suggests first that the gene present in birds corresponds to a sauropsid TRPV5 and not to a sauropsid TRPV6 as it has been previously suggested in the literature (Peng, 2011;Saito et al, 2011). The fact that birds can maintain calcium homeostasis according to their physiological requirements with just one of the calcium-selective TRPV channels could mean that a repertoire of two genes represent a case of functional redundancy in birds.…”

Section: Birds Retained Only One Calcium-selective Trpv Channelmentioning

confidence: 70%

“…Among vertebrates, it has been suggested that mammalian TRPV5 and TRPV6 channels originated from a duplication event in the last common ancestor of the group, between 312 and 177 million years ago (Peng, 2011;Saito et al, 2011). This would suggest that these genes belong to the mammalian clade exclusively and are not orthologs to TRPV5 and TRPV6 channels of other vertebrate groups.…”

Section: Introductionmentioning

confidence: 99%

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Evolutionary analyses unveil the molecular mechanism of fast inactivation in calcium-permeable TRP channels

Flores-Aldama

Zavala

et al. 2019

Preprint

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Important for calcium homeostasis, TRPV5 and TRPV6 are calcium-selective channels belonging to the transient receptor potential (TRP) gene family. In this study, we investigated the evolutionary history of these channels to add an evolutionary context to the already available physiological information. Phylogenetic analyses revealed that paralogs found in mammals, sauropsids, amphibians, and chondrichthyans, are the product of independent duplication events in the ancestor of each group. Within amniotes, we identified a traceable signature of three amino acids located at the amino-terminal intracellular region (HLH domain). The signature correlates well with both the duplication events and the phenotype of fast inactivation observed in mammalian TRPV6 channels. Electrophysiological recordings and mutagenesis suggest that calcium-induced fast inactivation represents an evolutionary innovation that emerged independently after gene duplication.

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Section: Amphibians and Chondrichthyanssupporting

confidence: 81%

Section: Birds Retained Only One Calcium-selective Trpv Channelmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

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Evolutionary analyses unveil the molecular mechanism of fast inactivation in calcium-permeable TRP channels

Flores-Aldama

Zavala

et al. 2019

Preprint

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“…Some channels in this subfamily also respond to redox status, intracellular calcium, low temperatures, or ligands such as menthol. For instance, TRPM2 play a role in the transduction of oxidative stress stimuli (Oancea et al, 2011). In cortical neurons, TRPM2 channels are involved in the cytotoxic influx of Ca 2+ that is induced by reactive oxygen species such as H 2 0 2 (Kaneko et al, 2006).…”

Section: Activation Mechanisms Of Trpsmentioning

confidence: 99%

TRP Channels Role in Pain Associated With Neurodegenerative Diseases

et al. 2020

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Transient receptor potential (TRP) are cation channels expressed in both non-excitable and excitable cells from diverse tissues, including heart, lung, and brain. The TRP channel family includes 28 isoforms activated by physical and chemical stimuli, such as temperature, pH, osmotic pressure, and noxious stimuli. Recently, it has been shown that TRP channels are also directly or indirectly activated by reactive oxygen species. Oxidative stress plays an essential role in neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, and TRP channels are involved in the progression of those diseases by mechanisms involving changes in the crosstalk between Ca 2+ regulation, oxidative stress, and production of inflammatory mediators. TRP channels involved in nociception include members of the TRPV, TRPM, TRPA, and TRPC subfamilies that transduce physical and chemical noxious stimuli. It has also been reported that pain is a complex issue in patients with Alzheimer's and Parkinson's diseases, and adequate management of pain in those conditions is still in discussion. TRPV1 has a role in neuroinflammation, a critical mechanism involved in neurodegeneration. Therefore, some studies have considered TRPV1 as a target for both pain treatment and neurodegenerative disorders. Thus, this review aimed to describe the TRP-dependent mechanism that can mediate pain sensation in neurodegenerative diseases and the therapeutic approach available to palliate pain and neurodegenerative symptoms throughout the regulation of these channels.

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“…Generally, chemical stimulation of trigeminal sensory afferents leads to different sensations (mostly stinging, burning, or cooling) that are triggered by activation of several polymodal receptors like transient receptors potential (TRP) channels that are activated by noxious stimuli e.g., harmful temperatures (Vay et al, 2012), various chemical ligands (Islam, 2011), and divalent cations (Ahern et al, 2005; Luebbert et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

In vivo monitoring of chemically evoked activity patterns in the rat trigeminal ganglion

Lübbert

Kyereme

Rothermel

et al. 2013

Front. Syst. Neurosci.

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Albeit lacking a sense of smell, anosmic patients maintain a reduced ability to distinguish different volatile chemicals by relying exclusively on their trigeminal system (TS). To elucidate differences in the neuronal representation of these volatile substances in the TS, we performed voltage-sensitive dye imaging (VSDI) in the rat trigeminal ganglion (TG) in vivo. We demonstrated that stimulus-specific patterns of bioelectrical activity occur within the TG upon nasal administration of ten different volatile chemicals. With regard to spatial differences between the evoked trigeminal response patterns, these substances could be sorted into three groups. Signal intensity and onset latencies were also dependent on the administered stimulus and its concentration. We conclude that particular compounds detected by the TS are represented by (1) a specific spatial response pattern, (2) the signal intensity, and (3) onset latencies within the pattern. Jointly, these trigeminal representations may contribute to the surprisingly high discriminative skills of anosmic patients.

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Transient Receptor Potential Channels

Cited by 41 publications

References 1 publication

Evolutionary analyses unveil the molecular mechanism of fast inactivation in calcium-permeable TRP channels

Evolutionary analyses unveil the molecular mechanism of fast inactivation in calcium-permeable TRP channels

TRP Channels Role in Pain Associated With Neurodegenerative Diseases

In vivo monitoring of chemically evoked activity patterns in the rat trigeminal ganglion

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