Transient receptor potential ion channels and cerebral stroke

Abstract

Methods:The databases Pubmed, and the National Library of Medicine were searched for literature. All papers on celebral stroke and transient receptor potential ion channels were considered.Results: Stroke is the second leading cause of death and disability, with an increasing incidence in developing countries. About 75 per cent of strokes are caused by occlusion of cerebral arteries, and substantial advances have been made in elucidating mechanisms how stroke affects the brain. Transient receptor potential (TRP) ion channels are calcium-permeable channels highly expressed in brain that drives Ca 2+ entry into multiple cellular compartments. TRPC1/3/4/6, TRPV1/2/4, and TRPM2/4/7 channels have been implicated in stroke pathophysiology. Conclusions:Although the precise mechanism of transient receptor potential ion channels in cerebral stroke is still unclear, it has the potential to be a therapeutic target for patients with stroke if developed appropriately. Hence, more research is needed to prove its efficacy in this context.

Role of TRPV1 in electroacupuncture‐mediated signal to the primary sensory cortex during regulation of the swallowing function

“… 40 Administration of a TRPV1 antagonist via intracerebroventricular injection 30 min anterior to the onset of ischemia abated neurological and motor deficits and reduced infarct size. 40 In this study, we investigated the role of TRPV1 at CV23 in mediating the effects of EA in treating PSD mice. The role of TRPV1 in the brain remains unclear and warrants further exploration in future studies.…”

“…Numerous recent investigations have intimated that TRPV1 is implicated in stroke pathophysiology, yet the particular mechanism eludes comprehension 40 . Administration of a TRPV1 antagonist via intracerebroventricular injection 30 min anterior to the onset of ischemia abated neurological and motor deficits and reduced infarct size 40 . In this study, we investigated the role of TRPV1 at CV23 in mediating the effects of EA in treating PSD mice.…”

“…TRPV1 exhibits ubiquitous expression throughout the brain, encompassing key regions such as the hippocampus, cortex, cerebellum, olfactory bulb, mesencephalon, and hindbrain, with its activation exerting a discernible impact on the pathophysiological state of cerebral ischemia 39 . Numerous recent investigations have intimated that TRPV1 is implicated in stroke pathophysiology, yet the particular mechanism eludes comprehension 40 . Administration of a TRPV1 antagonist via intracerebroventricular injection 30 min anterior to the onset of ischemia abated neurological and motor deficits and reduced infarct size 40 .…”

The Diagnostic Model of Ligusticum Chuanxiong Hort. Against Cerebral Stroke Using Network Pharmacology and Transcriptomics Analyses

“…It arises from the obstruction of cerebral blood vessels by plaque formation or an embolus formed elsewhere in the body. Hemorrhagic stroke accounts for 25% of cases and is caused by the rupture of a cerebral blood vessel [4]. The majority of stroke patients are over 40 years old, with a higher incidence in males than females [5].…”