Transient reduction of autoantibodies against oxidized ldl in patients with acute myocardial infarction

Schumacher, Martin; Eber, Bernd; Tatzber, Franz; Kaufmann, Peter; Halwachs, Gabriele; Fruhwald, Friedrich; Zweiker, Robert; Esterbauer, Hermann; Klein, W.

doi:10.1016/0891-5849(94)00216-7

Cited by 45 publications

(24 citation statements)

References 20 publications

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“…A transient decrease of the oLAb titer observed in our study is consistent with the findings of Schumacher et al (1995). A transient decrease of oLAb titer followed by an increase of the antibody titer was associated with successful convalescence after AMI (Schumacher et al 1995), while lethal outcome was associated with continuous decrease of the anti-oLDL antibody titer.…”

Section: Discussionsupporting

confidence: 81%

“…A transient decrease of oLAb titer followed by an increase of the antibody titer was associated with successful convalescence after AMI (Schumacher et al 1995), while lethal outcome was associated with continuous decrease of the anti-oLDL antibody titer. The change in titer of anti-oLDL antibodies should be primarily interpreted as a consequence of oxidative stress and subsequent lipid peroxidation.…”

Section: Discussionmentioning

confidence: 97%

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Persistent Oxidative Stress after Myocardial Infarction Treated by Percutaneous Coronary Intervention

Nikolić-Heitzler

Rabuzin

Tatzber

et al. 2006

Tohoku J. Exp. Med.

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[247][248][249][250][251][252][253][254][255] Acute myocardial infarction causing cardiac ischemia is responsible for the majority of cardiac related deaths. Medical interventions that ensure rapid reperfusion, such as percutaneous coronary intervention, are aimed to allow myocardial re-oxygenation. However, this generates reactive oxygen species, resembling ischemiareperfusion type of injury based on oxidative stress. In the present study we monitored dynamic changes of total serum peroxides, total antioxidant capacity and soluble intercellular adhesion molecule-1 as well as the titer of antibodies against oxidized low-density lipoproteins in the blood during the convalescence period of 32 patients with acute myocardial infarction treated by percutaneous coronary intervention. Samples were taken at admittance and at two hours, four hours, three days and seven days following percutaneous coronary intervention. Total antioxidant capacity dropped to 82% ( p < 0.05). The titer of antibodies against oxidized low-density lipoproteins transiently decreased within the first three days, and increased afterwards. The values of serum peroxides and soluble intercellular adhesion molecule-1 increased continuously in respect to the initial levels reaching the maximum at the time of release from hospital. These findings indicate a persistent oxidative stress that might be associated with intravascular inflammation in patients during convalescence and release from hospital. myocardial infarction; percutaneous coronary intervention; inflammation; soluble intercellular adhesion molecule-1; lipid peroxidation © 2006 Tohoku University Medical Press While oxidative stress has been shown to be related with the age and living habits (Ozbay and Dulker 2002), it plays an important role in the development of vascular diseases that affect vital organs, in particular brain and heart (Zarkovic 2003;Zarkovic et al. 2004;Madamanchi et al.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 97%

Persistent Oxidative Stress after Myocardial Infarction Treated by Percutaneous Coronary Intervention

Nikolić-Heitzler

Rabuzin

Tatzber

et al. 2006

Tohoku J. Exp. Med.

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“…As reported previously, the inverse correlation was found between the concentration of oLAb and age . Furthermore, a transient reduction of oLAb was found in patients during acute myocardial infarction (Schumacher et al, 1995). A high titer of circulating oLAb was observed in children compared to adults.…”

Section: Discussionmentioning

confidence: 94%

Enhanced plasma level of lipid peroxidation in Iranians could be improved by antioxidants supplementation

Meraji¹,

Ziouzenkova²,

Resch³

et al. 1997

Eur J Clin Nutr

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Objective: To study the in¯uence of supplementation with antioxidants on factors, which might increase the risk of coronary heart disease (CHD) in Iranians. Design: Twenty-one male volunteers enter the prospective, single-blind, randomized study. Setting: The supplementation was conducted at the Cardiovascular Center, University of Tehran, the biochemical analysis were carried out in the University of Graz. Subjects: Twenty-one male medical students were recruited by advertisement. Five subjects were dropped out due to lack of the compliance. Methods: One group of Iranians received 30 mg/d b-carotene and placebo for a-tocopherol; the other received b-carotene plus 400 IU a-tocopherol for ten weeks. Concentrations of antioxidants in plasma and low density lipoproteins (LDL), plasma lipid pro®le, autoantibody against oxidized LDL (oLAb) and malondialdehyde (MDA) concentrations in plasma were measured. Oxidative resistance of LDL was estimated using conjugated diene assay. Results: Iranians had a signi®cantly lower plasma levels of total cholesterol (P`0.002), LDL-cholesterol (P`0.01) and high density lipoprotein-cholesterol (P`0.002), compared to healthy Austrian subjects (n 13). Although the baseline concentrations of a-tocopherol and b-carotene were comparable with Austrians, lycopene, canthaxanthin and lutein were signi®cantly higher in Iranians (P`0.03±0.001). In vitro oxidative resistance of LDL, measured as lag-time, was slightly higher (P`0.01) in Iranians comparing with Austrians. Plasma MDA and oLAb concentrations were signi®cantly higher in Iranians (P`0.001). Both dietary supplementations reduced plasma MDA concentrations (P`0.001±0.001). A key ®nding was that a supplement combined with atocopherol caused also a signi®cant increase of oLAb concentration (P b 0.01) as well as the signi®cant increase of lag-time (P b 0.005). Conclusions: This study shows that high plasma MDA level of Iranians can be decreased by b-carotene supplementation with or without a-tocopherol. However, a-tocopherol is a more powerful antioxidant, which can increase the resistance of LDL to oxidation, reduce the MDA concentrations in plasma and increase autoantibodies to oLDL.

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“…15,16 In contrast, other studies found no such positive relationship between oxLDLAb titers and cardiovascular (CV) phenotypes. 17,18 Of interest, oxLDLAbs were detected in healthy individuals, 19 and a negative (inverse) association between total serum cholesterol and anti-OxLDLAb titers was reported in the general population. 20 However, oxLDLAbs were found to block the uptake of oxLDL by macrophages and localize to atherosclerotic plaques in vivo.…”

mentioning

confidence: 99%

Antibodies to Oxidized Low-Density Lipoproteins and Angiographically Assessed Coronary Artery Disease in White Patients

et al. 2003

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Background-Low-density lipoprotein (LDL) can be oxidatively modified by reactive oxygen species, thus generating oxLDL. The latter induce formation of specific antibodies (oxLDLAb), which are detectable in patients with atherosclerosis, in which they might play a pathogenic or a protective role. Thus, we aimed to investigate the association of antibodies with oxidized LDLs (oxLDL) (oxLDLAbs) with coronary artery disease (CAD) and acute coronary syndromes. Methods and Results-In a cross-sectional study of 529 consecutive patients undergoing quantitative coronary angiography for suspected CAD, we measured the titer of IgG oxLDLAbs by ELISA. With regression analysis techniques, we also investigated the determinants of oxLDLAb titer and the association of oxLDLAbs with CAD severity. We found no significant differences of oxLDLAb titer between groups of patients without and with different CAD severity. The oxLDLAb titer was 18.6 enzyme units (EU) (11.5 to 25.7 EU/mL) (mean, 95% CI) in patients without CAD; 16.8 EU (9.6 to 24.2 EU) in patients with stenosis Ͻ50%; and 19.9 EU (15 to 24.8 EU), 17.2 (13.8 to 20.6 EU), and 14.7 EU (12.1 to 17.3 EU) in those with in 1-, 2-, or 3-vessel Ն50% stenosis, respectively. Similarly, no differences of oxLDLAb titer between patients without and with acute coronary syndrome were found. The oxLDLAb titer correlated weakly with aging and with serum total, LDL, and HDL cholesterol and plasma homocysteine levels; however, only age and HDL cholesterol remained significant predictors of the oxLDLAb titer at a stepwise regression analysis. Conclusions-The results of this study, which was adequately powered from the statistical standpoint, provided no evidence for an association of IgG oxLDLAb titer with angiographically assessed CAD in whites. (Circulation. 2003; 108:2467-2472.)

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Transient reduction of autoantibodies against oxidized ldl in patients with acute myocardial infarction

Cited by 45 publications

References 20 publications

Persistent Oxidative Stress after Myocardial Infarction Treated by Percutaneous Coronary Intervention

Persistent Oxidative Stress after Myocardial Infarction Treated by Percutaneous Coronary Intervention

Enhanced plasma level of lipid peroxidation in Iranians could be improved by antioxidants supplementation

Antibodies to Oxidized Low-Density Lipoproteins and Angiographically Assessed Coronary Artery Disease in White Patients

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