2011
DOI: 10.3109/14767058.2011.604366
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Transient tachypnea of the newborn and congenital pneumonia: a comparative study

Abstract: In most cases, newborns with transient tachypnea and pneumonia are indistinguishable at presentation but clinical evolution is significantly different. The presence of perinatal infectious risk supports the diagnosis of pneumonia. Low Apgar score at one and five minutes was associated with both diseases, suggesting that etiologic factors may already be present at birth.

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Cited by 24 publications
(18 citation statements)
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“…Because clinical signs of TTN are not specific for the disease and can herald other more serious respiratory pathology, it is recommended practice to initiate empiric antibiotic coverage for presumed pneumonia in all newborns that present with respiratory distress [4,5,6,7]. This recommendation is not evidence-based.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Because clinical signs of TTN are not specific for the disease and can herald other more serious respiratory pathology, it is recommended practice to initiate empiric antibiotic coverage for presumed pneumonia in all newborns that present with respiratory distress [4,5,6,7]. This recommendation is not evidence-based.…”
Section: Discussionmentioning
confidence: 99%
“…Due to concern about delaying treatment for early-onset sepsis, it is recommended practice to initiate empiric antibiotic coverage for presumed pneumonia in all newborns who present with respiratory distress [4,5,6,7]. It has been a long-standing practice in our NICU not to initiate empiric antibiotic coverage for neonates with presumed TTN in the absence of either historical risk factors for neonatal sepsis or clinical concern for sepsis at birth.…”
Section: Introductionmentioning
confidence: 99%
“…Because clinical signs of TTN are not specific for the disease and can be confused with other serious respiratory pathology or infections at the early stage of onset, in clinical practice, most patients are treated with antibiotics for prophylaxis or empiric use immediately following admission [12,13,27,4,14]. However, this recommendation is not evidence-based, and in line with our observations, a previous study suggested that empiric postnatal antibiotic treatment might not be warranted for late preterm and term infants with TTN in the absence of specific infectious risk factors [25].…”
Section: Discussionmentioning
confidence: 99%
“…Since dyspnea has also been considered as a sign of neonatal infection, antibiotic treatment is initiated as early as possible to avoid delaying treatment of infections or early-onset sepsis and continued until the possibility of infection can be clinically excluded [12,13,27,4]. It is not surprising, then, that retrospective studies report that antibiotics are often provided to infants who do not need them [25,27].…”
Section: Introductionmentioning
confidence: 98%
“…Alveolar patterns with coarse, patchy parenchymal infiltrates, consolidation, and diffuse granularity are more typical for bacterial infections while parahilar streakiness, diffuse hazy lungs or reticulo-nodularity are more common in viral disease. The differential diagnoses to be considered on initial presentation are mainly surfactant deficiency syndrome and transient tachypnoe of the newborn, in addition meconium aspiration syndrome (MAS), pulmonary hemorrhage, pulmonary edema, primary pulmonary lymphangiectasis or pulmonary lymphangiomatosis, congestive heart failure (11,12) and Wilson-Mikity-syndrome (13). Additional investigations like echocardiography, high-resolution computed tomography, further laboratory studies, and in rare cases lung biopsy are helpful in the diagnostic work up.…”
Section: Clinical Presentation Classificationmentioning
confidence: 99%