In the paper, the crack parallel to and lying on the interface in the hard cladding material structure is regarded as the research object, theoretical model of the stress intensity factor (SIF) of the interface crack under the mechanical impact load is built. Based on it, the SIF of the crack parallel to and lying on the interface in the cermet cladding material structure under the mechanical impact load is investigated by using finite element analysis method. The influences of the cladding thickness ratio and mechanical impact stress amplitude on the interface SIF are investigated. The research results show that, at a certain moment, the interface SIFs decrease with increasing cladding thickness ratio when the mechanical impact stress amplitude is a constant and increase as the mechanical impact stress amplitude increases when the cladding thickness ratio is a constant.