Transition from enantioselective high performance to ultra-high performance liquid chromatography: A case study of a brush-type chiral stationary phase based on sub-5-micron to sub-2-micron silica particles

Cancelliere, Giovanna; Ciogli, Alessia; D’Acquarica, Ilaria; Gasparrini, Francesco; Kocergin, Jelena; Misiti, D.; Pierini, Marco; Ritchie, Harald; Simone, Patrizia; Villani, Claudio

doi:10.1016/j.chroma.2009.10.021

Cited by 67 publications

(37 citation statements)

References 23 publications

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“…Daicel group recently commercialised a sub-2 micron 5 cm column applicable for use on conventional HPLC [44]. The design is based on the simple way of reducing solvent usage by using a shorter column.…”

Section: Performance Of Chiralpak Ig-u ® : In Terms Of Enantioselectimentioning

confidence: 99%

“…A more dynamic saving in solvent usage is made by reducing the i.d. of the column, together with an appropriate scaling down in the flow rate [44]. Separation efficiencies are also recovered by reducing particle size down to sub-2 micron; because columns packed with sub-2 micron particles offer advantages over the more traditional systems containing 3 and 5 micron particles by allowing operation at higher flow rates without compromising efficiency [45].…”

Section: Performance Of Chiralpak Ig-u ® : In Terms Of Enantioselectimentioning

confidence: 99%

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Sub-2 μm Silica Particles in Chiral Separation

Ibrahim¹,

Ghanem²

2018

New Uses of Micro and Nanomaterials

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For decades, the race for the shortest chromatogram with the best resolution and separation efficiency has been the focus of researchers and manufacturers. Considerable advancement has been attained in the field of separation science with the widespread applications and outstanding performance of nanomaterials. According to the van Deemter equation, sub-2 micron particles employed in a conventional HPLC short column should subsequently result in analysis time reduction and efficiency improvements without the drawbacks of high pressure associated with sub-2 micron particles.This chapter provides comprehensive discussion about the applications of the new sub 2 microns silica particles in chiral separation of racemates.

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Section: Performance Of Chiralpak Ig-u ® : In Terms Of Enantioselectimentioning

confidence: 99%

Section: Performance Of Chiralpak Ig-u ® : In Terms Of Enantioselectimentioning

confidence: 99%

Sub-2 μm Silica Particles in Chiral Separation

Ibrahim¹,

Ghanem²

2018

New Uses of Micro and Nanomaterials

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show abstract

“…A decrease of the particle size reduces the axial dispersion and the intraparticle diffusion path, and the core–shell technology still more cuts down the intraparticle diffusion path, reducing the respective contribution to the peak broadening. Recently, these technologies have been employed in chiral chromatography, yielding excellent results . One may expect that, if the chemistry of a CSP is favorable with respect to enantiomer separation of a certain quinolone, the application of this CSP in the form of sub‐3 μm or core–shell particles will improve analytical characteristics of the separation essentially.…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Chiral separation of quinolones by liquid chromatography and capillary electrophoresis

2017

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The quinolones are derivatives of oxoquinolines and mostly known for their antibacterial and antiviral activities. Many quinolones are chiral compounds having asymmetric centers and important due to their enantioselective biological activities. In order to study the biological activities of quinolone enantiomers, to control the manufacturing of homochiral drugs and to prepare necessary quantities of pure enantiomers for preclinical or clinical trials, respective chiral separation methods are urgently needed. In this context, the present review discusses chromatographic and electrophoretic methods for the enantioseparation of chiral quinolones and provides some useful information on their physical and pharmaceutical properties. The drawbacks of currently used techniques are revealed and ways to overcome them are outlined. Moreover, recommendations for an optimal choice of a separation protocol are given.

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“…Some works reported chiral separations using commercial sub-2 m achiral columns by adding chiral additives [22,23]. Cancelliere et al [24] erably shorter analysis time and lower solvent consumption but similar resolutions when reduced particle size and shorter columns were used. Thoelen et al [18] reported the use of self-synthesized submicron mesoporous silica MCM-41 materials of 2.4 nm pore diameter in chiral HPLC.…”

Section: Introductionmentioning

confidence: 98%

Sub-1-micron mesoporous silica particles functionalized with cyclodextrin derivative for rapid enantioseparations on ultra-high pressure liquid chromatography

et al. 2010

Journal of Chromatography A

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Transition from enantioselective high performance to ultra-high performance liquid chromatography: A case study of a brush-type chiral stationary phase based on sub-5-micron to sub-2-micron silica particles

Cited by 67 publications

References 23 publications

Sub-2 μm Silica Particles in Chiral Separation

Sub-2 μm Silica Particles in Chiral Separation

Chiral separation of quinolones by liquid chromatography and capillary electrophoresis

Sub-1-micron mesoporous silica particles functionalized with cyclodextrin derivative for rapid enantioseparations on ultra-high pressure liquid chromatography

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