Transition metal complexes of a multidentate Schiff base ligand containing guanidine moiety: Synthesis, characterization, anti-cancer effect, and anti-microbial activity

El-Razek, Samar Ebrahim Abd; El-Gamasy, Sabreen Mohamed; Hassan, Marwa M; Abdel‐Aziz, Mohamed S.; Nasr, Sami Mohamed

doi:10.1016/j.molstruc.2019.127381

Cited by 62 publications

(25 citation statements)

References 26 publications

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“…The investigated azomethine metal chelates revealed significantly enhanced antimicrobial activities in comparison to the free ligand (MIC = 9.0-10.75 µg/mL) and showed comparable activities to ofloxacin and fluconazol. Very recently, copper(II), nickel(II), cobalt(II), manganese(II), iron(III), chromium(III), bismuth(III), and zinc(II) complexes of the guanidine Schiff bases 8 ( Figure 1) were reported [40]. Compounds were screened against S. aureus (Gram-positive), P. aeruginosa (Gram-negative) and the fungi strains, such as C. albicans and A. niger.…”

Section: Introductionmentioning

confidence: 99%

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Sovari

Zobi

2020

Chemistry

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Antimicrobial resistance is an increasingly serious threat to global public health that requires innovative solutions to counteract new resistance mechanisms emerging and spreading globally in infectious pathogens. Classic organic antibiotics are rapidly exhausting the structural variations available for an effective antimicrobial drug and new compounds emerging from the industrial pharmaceutical pipeline will likely have a short-term and limited impact before the pathogens can adapt. Inorganic and organometallic complexes offer the opportunity to discover and develop new active antimicrobial agents by exploiting their wide range of three-dimensional geometries and virtually infinite design possibilities that can affect their substitution kinetics, charge, lipophilicity, biological targets and modes of action. This review describes recent studies on the antimicrobial activity of transition metal complexes of groups 6–12. It focuses on the effectiveness of the metal complexes in relation to the rich structural chemical variations of the same. The aim is to provide a short vade mecum for the readers interested in the subject that can complement other reviews.

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Section: Introductionmentioning

confidence: 99%

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Sovari

Zobi

2020

Chemistry

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“…Cup plate diffusion technique was used to assess the antimicrobial actions of anise oil -based nanoemulsion by means of using the tested microbes; Gram-positive bacterium: Staphylococcus aureus ( S. aureus , ATCC 6538), Gram-negative bacterium: Escherichia coli ( E. coli , ATCC 25922), yeast: Candida albicans ( C. albicans , ATCC 10231) and the fungus: Aspergillus niger ( A. niger , NRRL A-326). Both bacteria and yeast were grown on nutrient agar medium, whereas the fungus was grown on Czapek–Dox medium [ 21 , 22 ]. Neomycin and cycloheximide were used as antibacterial and antifungal references, respectively.…”

Section: Methodsmentioning

confidence: 99%

Facile Synthesis of Natural Anise-Based Nanoemulsions and Their Antimicrobial Activity

et al. 2021

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Anise oil was prepared in its nanoemulsion form to facilitate the penetration of microbial walls, causing microbe mortality. The penetration occurred easily owing to the reduction in its size (nm). Nanoemulsions with different concentrations of anise oil were prepared using lecithin as an emulsifying agent with the aid of an ultra-sonification process. Their morphological and chemical properties were then characterized. The promising constituents were l-Menthone (11.22%), Gurjunene (6.78%), Geranyl acetate (4.03%), Elemene (3.93%), Geranyl tiglate (3.53%), geraniol (3.48%), linalool (0.17%) as well as camphene (0.12%). Different concentrations of prepared anise oil in micro and nanoemulsions were tested as antimicrobial agents against Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli), yeast (Candida albicans) and fungi (Asperigillus niger). The findings illustrated that the anise oil-based nanoemulsion exhibited better results. Different biochemical and biological evaluations of anise oil nanoemulsions were conducted, including determining killing times, antioxidant activities (using three different methods), and total phenolics. A trial to estimate the mode of action of anise oil-based nanoemulsion as an antimicrobial agent against S. aureus and C. albicans was performed via studying the release of reducing sugars and protein and conducting scanning electron microscopy.

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“…The N,O-donor ligands include the salen type ligands studied in a number of works [31][32][33][34]. Three mononuclear copper complexes 17-19 with bis-Schiff base ligands HL 17 -HL 19 were prepared and structurally characterized [31].…”

Section: N-donor Ligandsmentioning

confidence: 99%

Recent Studies on the Antimicrobial Activity of Copper Complexes

Zalevskaya

Gur’eva

2021

Russ J Coord Chem

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The analysis of publications in 2020, devoted to the synthesis of copper(II) complexes and the study of their antimicrobial properties, indicates that this area of medicinal chemistry is promising. Organic compounds of various classes were studied as starting ligands. First of all, these are N-donor imines, amines, heterocyclic compounds, as well as N,O-donor ligands and sulfur-containing ligands. In most works, the fact of a higher biological activity of the metal complex in comparison with the corresponding ligand was established. Evaluating the influence of the nature of the metal on the antimicrobial activity of the metal complex, the authors most often come to the conclusion that it is copper(II) complexes that are the most effective inhibitors of the growth of pathogenic bacteria. The scale of the studies presented indicates a high interest in this group of metal complexes, and the results indicate good prospects for using copper complexes as antimicrobial drugs.

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Transition metal complexes of a multidentate Schiff base ligand containing guanidine moiety: Synthesis, characterization, anti-cancer effect, and anti-microbial activity

Cited by 62 publications

References 26 publications

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Facile Synthesis of Natural Anise-Based Nanoemulsions and Their Antimicrobial Activity

Recent Studies on the Antimicrobial Activity of Copper Complexes

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