Transition Metal/Lewis Acid Catalyzed Reactions of Zerumbone for Diverse Molecular Motifs

Biji, Mohanan; Prabha, Bernard; Lankalapalli, Ravi S.; Radhakrishnan, K. V.

doi:10.1002/tcr.202100206

Cited by 3 publications

(1 citation statement)

References 76 publications

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“…In addition, bio-isosteric replacements in the ortho position of the phenyl ring of zerumbone led to a series of new hydrazones, including 5a-f and 9a-f, with confirmed cytotoxic effects against three human cancer cell lines, HepG-2, SK-LU-1, and MCF-7 [ 111 ]. Another derivative, zerumbone epoxide, results from numerous reactions triggered by transition metal/Lewis acid-catalysed 1,4-conjugate addition of zerumbone [ 113 ].…”

Section: Zerumbone Derivativementioning

confidence: 99%

Healthy Zerumbone: From Natural Sources to Strategies to Improve Its Bioavailability and Oral Administration

Ibáñez

Sánchez-Ballester

Blázquez

2022

Plants

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Zerumbone is a multifunctional compound with antimicrobial, antitumor, hyperalgesic, antioxidant and anti-inflammatory applications, and constitutes a point molecule for the future synthesis of derivatives with improved efficiency. This monocyclic sesquiterpenoid is found in high content in wild ginger (Zingiber zerumbet Smith), a perennial herb with economic importance as an ornamental as well as a medicinal plant. The presence of zerumbone is a distinctive feature that allows identification and differentiation from other species, not only in Zingiber, but also in Curcuma, Alpinia, Boesenbergia, Ethlingera and Ammomum spp., as well as related families (Costaceaee). To successfully use zerumbone in areas such as medicine, food and agriculture, further research on improving its low solubility and bioavailability, as well as its preservation, is a major current priority. In addition, despite its promising pharmacological activities, preclinical and clinical studies are required to demonstrate and evaluate the in vivo efficacy of zerumbone.

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Section: Zerumbone Derivativementioning

confidence: 99%

Healthy Zerumbone: From Natural Sources to Strategies to Improve Its Bioavailability and Oral Administration

Ibáñez

Sánchez-Ballester

Blázquez

2022

Plants

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Transannular Electrophilic Cyclizations

Reyes,

Prieto,

Uria

et al. 2024

Reference Module in Chemistry, Molecular Sciences and Chemical Engineering

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Targeting the mTOR Pathway in Hepatocellular Carcinoma: The Therapeutic Potential of Natural Products

Chen,

Zhang,

Zhou

et al. 2024

JIR

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Despite advancements in cancer treatment through surgery and drugs, hepatocellular carcinoma (HCC) remains a significant challenge, as reflected by its low survival rates. The mammalian target of rapamycin (mTOR) signaling pathway plays a crucial role in regulating the cell cycle, proliferation, apoptosis, and metabolism. Notably, dysregulation leading to the activation of the mTOR signaling pathway is common in HCC, making it a key focus for in-depth research and a target for current therapeutic strategies. This review focuses on the role of the mTOR signaling pathway and its downstream effectors in regulating HCC cell proliferation, apoptosis, autophagy, cell cycle, and metabolic reprogramming. Moreover, it emphasizes the potential of natural products as modulators of the mTOR signaling pathway. When incorporated into combination therapies, these natural products have been demonstrated to augment therapeutic efficacy and surmount drug resistance. These products target key signaling pathways such as mTOR signaling pathways. Examples include 11-epi-sinulariolide acetate, matrine, and asparagus polysaccharide. Their inhibitory effects on these processes suggest valuable directions for the development of more effective HCC therapeutic strategies. Various natural products have demonstrated the ability to inhibit mTOR signaling pathway and suppress HCC progression. These phytochemicals, functioning as mTOR signaling pathway inhibitors, hold great promise as potential anti-HCC agents, especially in the context of overcoming chemoresistance and enhancing the outcomes of combination therapies.

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Transition Metal/Lewis Acid Catalyzed Reactions of Zerumbone for Diverse Molecular Motifs

Cited by 3 publications

References 76 publications

Healthy Zerumbone: From Natural Sources to Strategies to Improve Its Bioavailability and Oral Administration

Healthy Zerumbone: From Natural Sources to Strategies to Improve Its Bioavailability and Oral Administration

Transannular Electrophilic Cyclizations

Targeting the mTOR Pathway in Hepatocellular Carcinoma: The Therapeutic Potential of Natural Products

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