Transition Metal-Mediated DNA Adsorption on Polydopamine Nanoparticles

Zandieh, Mohamad; Liu, Juewen

doi:10.1021/acs.langmuir.0c00046

Cited by 32 publications

(38 citation statements)

References 47 publications

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“…It is common to use Tris buffer at pH 8.5, [50][51][52][53][54] or to directly add NaOH to an aqueous solution of dopamine. [47,55] Interestingly, some works claimed to have synthesized PDA at lower pH, but extra oxidizing agents were needed. Wei et al showed that by adding ammonium persulfate and sodium periodate, polymerization can occur at neutral and even acidic pH.…”

Section: Effect Of Phmentioning

confidence: 99%

“…PDA is a zwitterionic material as it contains both amine groups and phenolic hydroxyl groups, [88] rendering a pHswitchable surface with an isoelectric point of ≈4.5. [47,89] Based on this, pH-responsive PDA was used for the adsorption of charged molecules. [90] Below the isoelectric point the PDA surface charge becomes positive, while DNA is negatively charged above pH 2 due to the phosphate backbone ( Figure 4A).…”

Section: Low Ph-assisted Dna Adsorptionmentioning

confidence: 99%

“…Catecholamines are good metal ligands. [62,64,65,93,94] By doping metal ions onto PDA NPs either during (predoping) [64] or after synthesis (postdoping), [47] the surface charge becomes less negative than bare PDA NPs ( Figure 5A). DNA interacts with different metal ions through its nucleobases and phosphate backbone with different affinities.…”

Section: Metal-mediated Dna Adsorptionmentioning

confidence: 99%

“…Values in panel (A) were adapted from refs. [47,64] . Kinetics of DNA adsorption on PDA NPs in the presence of different concentrations of B) Na + , C) Mg 2+ , and D) Ca 2+ .…”

Section: Metal-mediated Dna Adsorptionmentioning

confidence: 99%

“…Species from all stages of the oxidation pathway attach together through covalent interactions, and noncovalent π-π stacking and hydrogen bonding to form PDA aggregates ( Figure 1C). [45][46][47] Norepinephrine is another important catecholamine and neurotransmitter. It differs from dopamine by having an extra hydroxyl group on the aliphatic carbon adjacent to the amine group, which increases its hydrophilicity ( Figure 1A).…”

Section: Introductionmentioning

confidence: 99%

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Interfacing DNA and Polydopamine Nanoparticles and Its Applications

Zandieh

Hagar

Liu

2020

Part & Part Syst Charact

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and drugs, [21,22] and decrease the toxicity of biomaterials. [23] Finally, PDA can be used for sensing. PDA-containing biosensors have been used to detect various organic molecules, [24,25] biomolecules, [26,27] and metal ions. [28] Many sensing and biomedical applications of PDA have been realized through interfacing it with biomolecules such as DNA, enzymes, and antibodies. DNA has gained popularity in the last few decades as a functional polymer thanks to its high stability, low cost, and ease of synthesis. [29-34] More importantly, DNA can bind not only its complementary sequence but also a diverse range of other molecules by using DNA aptamers. [35] Catalytically active DNA sequences, known as DNAzymes, have also been discovered. [36] Combining the unique properties of PDA and DNA has produced many interesting hybrid materials. The surface of PDA is different from most inorganic and even other organic NPs, and understanding its surface interactions is critical for applications. Given the many papers on DNA-functionalized PDA which have been published, it is now a good time to summarize this topic, which was not previously reviewed. This review has two main purposes. First, it describes the interfacial interactions between DNA and PDA with a focus on methods to achieve noncovalent and covalent conjugates. Second, we review the representative applications of such conjugates. In the end, some challenges of the field are discussed, and a few future research directions are proposed. 2. Dopamine, Its Analogs, and PDA The extraordinary wet adhesion of some marine creatures, such as mussels, is caused by their secreted proteins that are rich in catecholamine groups. This has inspired scientists to develop a universal coating material that can mimic the natural wet adhesion. [37] Although dopamine is a catecholamine, PDA is not yet found naturally. PDA is a synthetic analog of melanin, and natural melanin exists in the color pigments of the skin, hair, and eyes of the human body. Melanin is produced by the aggregation and polymerization of catecholamines such as DOPA or tyrosine (Figure 1A). [38,39] To date, the polymerization pathways of dopamine are still unknown, but a few likely pathways have been proposed. [40-44] Polydopamine (PDA) is polymerized from dopamine under oxidative and basic conditions. PDA is a biocompatible material with great versatility for coating various surfaces and it can also form nanoparticles. DNA oligonucleotides are highly stable, and they can recognize a diverse range of molecules from complementary nucleic acids, proteins to small molecules and metal ions. To enhance the molecular recognition function of PDA, it is interfaced with DNA and the conjugates have achieved a wide range of applications in biomedical and analytical science. In this review, the chemistry of some catecholamines, including dopamine and PDA, is first briefly introduced and variables in the PDA synthesis are highlighted. Strategies to promote DNA adsorption on PDA are then discussed including the use of low pH and...

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Section: Effect Of Phmentioning

confidence: 99%

Section: Low Ph-assisted Dna Adsorptionmentioning

confidence: 99%

Section: Metal-mediated Dna Adsorptionmentioning

confidence: 99%

“…Values in panel (A) were adapted from refs. [47,64] . Kinetics of DNA adsorption on PDA NPs in the presence of different concentrations of B) Na + , C) Mg 2+ , and D) Ca 2+ .…”

Section: Metal-mediated Dna Adsorptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Interfacing DNA and Polydopamine Nanoparticles and Its Applications

Zandieh

Hagar

Liu

2020

Part & Part Syst Charact

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Polydopamine‐Enabled Biomimetic Surface Engineering of Materials: New Insights and Promising Applications

Saraf,

Prateek,

Ranjan

et al. 2023

Adv Materials Inter

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Surface modification is an important approach to modify the properties of materials. Numerous approaches have been adopted to tailor the properties of such materials, which have been proven successful at many scales and parameters. However, most of these techniques are often tedious, poorly adhesive, costly, sometimes hazardous, and surface‐specific, hence cannot be extended on a large scale and all kinds of surfaces. These shortcomings have led to the emergence of new dopamine (DA) based green surface modification technique where a thin polydopamine (PDA) layer is deposited on surfaces through a facile polymerization of DA under alkaline conditions to enable the surface for various applications. This surface modification strategy has several advantages over other techniques in deposition processing under mild conditions, cost‐effective and straightforward ingredients, and applicability to all kinds of surfaces regardless of their sizes, shapes, and types. Moreover, the PDA layer enhances the surface functionality. Therefore, it can serve as a versatile platform for various secondary reactions for a wide range of applications. Herein, the chemistry of DA is summarized and its polymerized form PDA for the modification of different families of materials’ surfaces with an emphasis on energy, environmental and biological applications.

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Sunflower Pollen‐Derived Microspheres Selectively Absorb DNA for microRNA Detection

Yang,

Mou,

Liu

et al. 2024

ChemBioChem

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Herein, we report the finding that a naturally sunflower pollen‐derived microspheres (HSECs) with hierarchical structures can selectively absorb polyC and polyA with high efficiency and affinity. HSECs exhibit the capability to selectively absorb polyC and polyA ssDNA under neutral and acidic conditions. It has been observed that the presence of metal cations, specifically Ca2+, enhances the absorption efficiency of HSECs. Mechanically, this absorption phenomenon can be attributed to both electrostatic interactions and cation‐π interactions. Such an appealing property enables the functionalization of HSECs for broad potential biomedical applications, such as microRNA detection.

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Transition Metal-Mediated DNA Adsorption on Polydopamine Nanoparticles

Cited by 32 publications

References 47 publications

Interfacing DNA and Polydopamine Nanoparticles and Its Applications

Interfacing DNA and Polydopamine Nanoparticles and Its Applications

Polydopamine‐Enabled Biomimetic Surface Engineering of Materials: New Insights and Promising Applications

Sunflower Pollen‐Derived Microspheres Selectively Absorb DNA for microRNA Detection

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