Transition of Treatment for Ground Glass Opacity–Dominant Non-Small Cell Lung Cancer

Handa, Yoshinori; Tsutani, Yasuhiro

doi:10.3389/fonc.2021.655651

Cited by 13 publications

(8 citation statements)

References 32 publications

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“…CTR is used for surgical procedures for the early stage of lung adenocarcinoma because it presented invasiveness ( 8 ). The part-solid nodule with CTR of <0.5 is a good indication for sublobar resection following the Japanese Clinical Oncology Group Trial ( 9 ). GGO and solid portion tend to correspond to lepidic patterns and invasive lesions although this relationship is not absolute.…”

Section: Discussionmentioning

confidence: 99%

Significance of histologic subtype size as a prognostic indicator in stage IA lung adenocarcinoma

Jeon,

Kim,

Sim

2023

J Thorac Dis

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Background Predicting prognosis is complex due to a unique characteristic in stage IA lung adenocarcinoma. The feature indicated heterogeneous histologic subtype and ground glass opacity (GGO). Many studies demonstrated different prognoses according to histologic subtype or non-GGO lesion. This study aimed to evaluate the clinical outcomes following each histologic subtype size in stage IA lung adenocarcinoma and identify the prognostic impact of each histologic subtype size. Methods The medical records of 550 patients with pathological stage IA lung adenocarcinoma were reviewed. Histologic subtype size was estimated by multiplying the tumor’s maximum diameter by the proportion of each histologic subtype. Univariate and multivariate analyses were conducted to identify the prognostic role of each histologic subtype size in stage IA lung adenocarcinoma. Results The median age and tumor size were 63 [25–82] years and 1.8 [0.3–3] cm, respectively. Acinar (42.0%) and lepidic (44.4%) were the most common among the predominant subtype. Each subtype size was estimated and re-categorized following the current staging system. The disease-free interval (DFI) was significantly different following each histologic subtype size. Multivariate analysis for DFI revealed more acinar, micropapillary, and solid subtypes and fewer lepidic subtypes with worse prognoses. Conclusions The prognosis for DFI is determined through a complex process by various variables in stage IA lung adenocarcinoma. Each subtype size has a more prognostic impact than the predominant subtype.

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Section: Discussionmentioning

confidence: 99%

Significance of histologic subtype size as a prognostic indicator in stage IA lung adenocarcinoma

Jeon,

Kim,

Sim

2023

J Thorac Dis

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“…Studies have also shown that the maximum standard uptake value (SUVmax) of lung nodules in PET-CT can be used as an important preoperative factor to predict the pathological malignancy and prognosis of lung adenocarcinoma. Lung nodules with high SUVmax, even GGO-dominated nodules, are often malignant and often accompanied by lymph node metastasis (24,(37)(38)(39). A multicenter study of 502 patients with stage IA lung adenocarcinoma found that patients with SUVmax <1.5 could not undergo systematic lymph node dissection, even if the tumor reached 3 cm (40).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, in the eighth edition of the TNM staging, it is recommended to define the T staging of part-solid lung cancer based on the solid part size ( 13 ). Moreover, some scholars found that CTR is also a reliable indicator for predicting lymph node metastasis in PSILA ( 23 , 24 ). However, there were also studies based on a large number of cases that revealed that, although both tumor size and CTR can predict the aggressiveness of PSILA, they were not associated with lymph node metastasis and patients’ prognosis ( 2 , 25 , 26 ).…”

Section: Discussionmentioning

confidence: 99%

A predictive nomogram for lymph node metastasis in part-solid invasive lung adenocarcinoma: A complement to the IASLC novel grading system

et al. 2022

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BackgroundThe International Association for the Study of Lung Cancer (IASLC) proposed a novel grading system for invasive lung adenocarcinoma, but lymphatic invasion was not evaluated. Meanwhile, the scope of lymph node dissection in part-solid invasive lung adenocarcinoma (PSILA) is still controversial. Therefore, this study aims to explore preoperative risk factors for lymph node metastasis in PSILA, to provide reference for intraoperative dissection of lymph nodes.MethodsFrom 2018 to 2020, clinical data of patients (stage cN0) consecutively diagnosed as PSILA were retrospectively analyzed and classified according to the novel grading system. Logistic regression was conducted to screen the clinicopathological factors of lymph node metastasis in PSILA.ResultsA large cohort of 960 patients with PSILA who underwent lobectomy or sub-lobectomy were enrolled. By logistic regression analyses, solid part size, bronchial cutoff sign, spiculation, and carbohydrate antigen 199 (CA199) were eventually identified as independent risk factors for lymph node metastasis, based on which a nomogram was built to preoperatively predict the risk of lymph node metastasis [area under the receiver operating characteristic curve (AUC)=0.858; concordance index = 0.857; best cutoff, 0.027]. This suggests that intraoperative systematic lymph node dissection is recommended when the predicted risk value exceeds 0.027. Reproducibility of the novel grading system was verified.ConclusionsThe novel IASLC grading system was applicative in real world. The nomogram for preoperative prediction of lymph node metastasis may provide reference for the lymph node dissection strategy during PSILA surgeries.

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“…At present, the choice of sublobectomy has no consensus. The size, location, and proportion of solid components of pulmonary nodules should be considered to decide the surgical method ( 35 , 36 ). Group 5 (purple), the last one, was associated with GGO pathology.…”

Section: Discussionmentioning

confidence: 99%

Knowledge mapping visualization of the pulmonary ground-glass opacity published in the web of science

Zhang²,

Gao³

et al. 2022

Front. Oncol.

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ObjectivesWith low-dose computed tomography(CT) lung cancer screening, many studies with an increasing number of patients with ground-glass opacity (GGO) are published. Hence, the present study aimed to analyze the published studies on GGO using bibliometric analysis. The findings could provide a basis for future research in GGO and for understanding past advances and trends in the field.MethodsPublished studies on GGO were obtained from the Web of Science Core Collection. A bibliometric analysis was conducted using the R package and VOSviewer for countries, institutions, journals, authors, keywords, and articles relevant to GGO. In addition, a bibliometric map was created to visualize the relationship.ResultsThe number of publications on GGO has been increasing since 2011. China is ranked as the most prolific country; however, Japan has the highest number of citations for its published articles. Seoul National University and Professor Jin Mo Goo from Korea had the highest publications. Most top 10 journals specialized in the field of lung diseases. Radiology is a comprehensive journal with the greatest number of citations and highest H-index than other journals. Using bibliometric analysis, research topics on “prognosis and diagnosis,” “artificial intelligence,” “treatment,” “preoperative positioning and minimally invasive surgery,” and “pathology of GGO” were identified. Artificial intelligence diagnosis and minimally invasive treatment may be the future of GGO. In addition, most top 10 literatures in this field were guidelines for lung cancer and pulmonary nodules.ConclusionsThe publication volume of GGO has increased rapidly. The top three countries with the highest number of published articles were China, Japan, and the United States. Japan had the most significant number of citations for published articles. Most key journals specialized in the field of lung diseases. Artificial intelligence diagnosis and minimally invasive treatment may be the future of GGO.

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Transition of Treatment for Ground Glass Opacity–Dominant Non-Small Cell Lung Cancer

Cited by 13 publications

References 32 publications

Significance of histologic subtype size as a prognostic indicator in stage IA lung adenocarcinoma

Significance of histologic subtype size as a prognostic indicator in stage IA lung adenocarcinoma

A predictive nomogram for lymph node metastasis in part-solid invasive lung adenocarcinoma: A complement to the IASLC novel grading system

Knowledge mapping visualization of the pulmonary ground-glass opacity published in the web of science

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