Transitional-Cell Splenic Cyst Excised Without Splenectomy

Fonkalsrud, Eric W.; Walford, Roy L.

doi:10.1001/archsurg.1960.01300040120023

Cited by 8 publications

(3 citation statements)

References 5 publications

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“…8 The cysts of the present case are classified as true cysts of the spleen 10 and are very rare. The lining of a cyst may be composed of not only stratified squamous epithelium cells but alternatively, flat cells like the mesothelium, such as in our case and others, 11 transitional cells, 12 or mucus‐secreting epithelium. 13 The nature of the cells lining the splenic cyst suggests a different origin.…”

Section: Discussionmentioning

confidence: 64%

“… 17 It is thought that the cyst derives from the inclusion of mesonephric structures in the developing splenic anlage as well. 12 Alternatively, a splenic epidermoid cyst of the pancreas may be derived from the aberrant pancreatic duct epithelium in an accessory spleen embedded in the pancreatic tail. 2 The present case serves to clarify the origin of true cysts of the spleen, because a comparison is possible with two types of cyst; that is, one with a layer of flat cells located in the spleen and the other with squamous cell epithelium located in the accessory spleen.…”

Section: Discussionmentioning

confidence: 99%

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Epithelial splenic cysts in an intrapancreatic accessory spleen and spleen

Sasou

Nakamura

Inomata

1999

Pathology International

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A rare case of cysts simultaneously occurring in the intrapancreatic accessory spleen and spleen in a 49-year-old female is reported. The patient underwent distal pancreatomy for a cystic tumor of the pancreas, and a splenectomy. A multilocular cyst (4.3 x 2.6 cm) in an accessory spleen at the pancreas tail, and a solitary cyst (1.2 x 0.9 cm) of the spleen were found. The cyst in the intrapancreatic accessory spleen was lined by non-keratinizing stratified squamous epithelium, and the spleen cyst by a single layer of flat epithelium; these lining cells were positive for Alcian blue stain and periodic acid-Schiff reaction, and were immunohistochemically positive for cytokeratin, HBME-1 and Sialyl-Tn. Epithelial membrane antigen, carcinoembryonic antigen and CA19-9 were positive in the accessory spleen cyst but were negative in the spleen cyst. An electron microscopic examination of the flat epithelium of the spleen cyst revealed numerous microvilli on the surface, cytoplasmic microfilaments, and a number of tight junctions between adjacent cells. These features suggested that the two cysts differ in nature, and origin; the accessory spleen cyst may be an embryonic inclusion of the pancreas duct while the spleen cyst may be an inclusion cyst of the mesothelium.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Epithelial splenic cysts in an intrapancreatic accessory spleen and spleen

Sasou

Nakamura

Inomata

1999

Pathology International

View full text Add to dashboard Cite

show abstract

“…The histogenesis of these epithelial cysts has been thought to be teratomatous (germ cells) [9], ectodermal (fetal squamous epithelium) [9], mesothelial (peritoneal mesothelium) [22], mesonephric (primordial Wolffian tissue) [6] or entodermal (foregut epithelium) [23]. Pancreatic tissue, an entodermal derivative, is reported to occur in the spleen.…”

Section: Discussionmentioning

confidence: 99%