Transitory macrophages in the white matter of the developing visual cortex. I. Light and electron microscopic characteristics and distribution

Innocenti, Giorgio M.; Koppel, H.; Clarke, Stéphanie

doi:10.1016/0165-3806(83)90200-6

Cited by 95 publications

(25 citation statements)

References 28 publications

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“…Their location at meeting points between the main white-matter tracts is highly suggestive of a role in eliminating exuberant axons, promoting neuroaxonal growth, and guiding axonal pathways (Innocenti et al 1983a,b;Perry et al 1985;Chamak et al 1995;Rezaie, 2003). Findings in kittens suggest that the presence of (Innocenti et al 1983a). However, the exact significance of these clusters remains unproven, as microglial cells have been reported to accumulate at specific white-matter sites after the corresponding axons reach their final target (Earle & Mitrofanis, 1997).…”

Section: Accumulation Of Intermediate Microglia In Clusters In the Dementioning

confidence: 99%

“…4B). Such microglial 'hot spots' have been reported in white-matter tracts in rodents (Perry et al 1985;Ashwell, 1991), kittens (Innocenti et al 1983a), and humans (Kershman, 1939;Andjelkovic et al 1998). These microglia clusters, which are transient structures specific to the developing brain, may be 'waiting sites' for glial cells that have entered the brain and will subsequently colonize the parenchyma (del Rio Hortega, 1932;Innocenti et al 1983a).…”

Section: Accumulation Of Intermediate Microglia In Clusters In the Dementioning

confidence: 99%

“…Such microglial 'hot spots' have been reported in white-matter tracts in rodents (Perry et al 1985;Ashwell, 1991), kittens (Innocenti et al 1983a), and humans (Kershman, 1939;Andjelkovic et al 1998). These microglia clusters, which are transient structures specific to the developing brain, may be 'waiting sites' for glial cells that have entered the brain and will subsequently colonize the parenchyma (del Rio Hortega, 1932;Innocenti et al 1983a). Their location at meeting points between the main white-matter tracts is highly suggestive of a role in eliminating exuberant axons, promoting neuroaxonal growth, and guiding axonal pathways (Innocenti et al 1983a,b;Perry et al 1985;Chamak et al 1995;Rezaie, 2003).…”

Section: Accumulation Of Intermediate Microglia In Clusters In the Dementioning

confidence: 99%

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Early microglial colonization of the human forebrain and possible involvement in periventricular white‐matter injury of preterm infants

et al. 2010

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Amoeboid microglial subpopulations visualized by antibodies against ionized calcium-binding adapter molecule 1, CD68, and CD45 enter the forebrain starting at 4.5 postovulatory or gestational weeks (gw). They penetrate the telencephalon and diencephalon via the meninges, choroid plexus, and ventricular zone. Early colonization by amoeboid microglia-macrophages is first restricted to the white matter, where these cells migrate and accumulate in patches at the junctions of white-matter pathways, such as the three junctions that the internal capsule makes with the thalamocortical projection, external capsule and cerebral peduncle, respectively. In the cerebral cortex anlage, migration is mainly radial and tangential towards the immature white matter, subplate layer, and cortical plate, whereas pial cells populate the prospective layer I. A second wave of microglial cells penetrates the brain via the vascular route at about 12-13 gw and remains confined to the white matter. Two main findings deserve emphasis. First, microglia accumulate at 10-12 gw at the cortical plate-subplate junction, where the first synapses are detected. Second, microglia accumulate in restricted laminar bands, most notably around 19-30 gw, at the axonal crossroads in the white matter (semiovale centre) rostrally, extending caudally in the immature white matter to the visual radiations. This accumulation of proliferating microglia is located at the site of white-matter injury in premature neonates. The spatiotemporal organization of microglia in the immature white and grey matter suggests that these cells may play active roles in developmental processes such as axonal guidance, synaptogenesis, and neurodevelopmental apoptosis as well as in injuries to the developing brain, in particular in the periventricular white-matter injury of preterm infants.

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Section: Accumulation Of Intermediate Microglia In Clusters In the Dementioning

confidence: 99%

Section: Accumulation Of Intermediate Microglia In Clusters In the Dementioning

confidence: 99%

Section: Accumulation Of Intermediate Microglia In Clusters In the Dementioning

confidence: 99%

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Early microglial colonization of the human forebrain and possible involvement in periventricular white‐matter injury of preterm infants

et al. 2010

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“…In the mouse peripheral nervous system, Schwann cells depend upon LPA signalling for both survival (Contos et al, 2000;Weiner and Chun, 1999) and proper myelination (Anliker et al, 2013;Weiner et al, 2001), and they express Lpar1, Lpar4 and Lpar6 (Anliker et al, 2013). Microglia are the resident macrophages of the CNS and have developmental roles (Innocenti et al, 1983). Mouse microglia express Lpar1 and possibly Lpar3 (Moller et al, 2001).…”

Section: Lpa In the Nervous Systemmentioning

confidence: 99%

Lysophosphatidic acid signalling in development

et al. 2015

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Lysophosphatidic acid (LPA) is a bioactive phospholipid that is present in all tissues examined to date. LPA signals extracellularly via cognate G protein-coupled receptors to mediate cellular processes such as survival, proliferation, differentiation, migration, adhesion and morphology. These LPA-influenced processes impact many aspects of organismal development. In particular, LPA signalling has been shown to affect fertility and reproduction, formation of the nervous system, and development of the vasculature. Here and in the accompanying poster, we review the developmentally related features of LPA signalling.

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“…Microglia, the resident phagocytic cells of the central nervous system (7), take on a ramified quiescent morphology in the normal mature brain, but the active forms of intermediate and amoeboid morphologies are most common in normal developing brain (8). Activated microglia in the developing white matter are involved in eliminating transcallosal projections (9), vascularization and angiogenesis (7), myelination (10), programmed cell death, synaptic pruning (11), and axonal guidance (12).…”

mentioning

confidence: 99%