Translating microRNAs into biomarkers: What is new for pediatric cancer?

Carvalho, Ivna Néria Silva Ribamar de; Freitas, Renata Mendes de; Vargas, Fernando

doi:10.1007/s12032-016-0766-4

Cited by 37 publications

(24 citation statements)

References 102 publications

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“…38 Moreover, finding new therapies and drugs could help increase the survival rate of patients with Rb. 38 It has been revealed that cyclin-dependent kinases (CDKs) phosphorylate RB protein in cycling cells. 39 D class cyclins (ie, D1) are as one important part of CDKs that have regulatory roles.…”

Section: Curcumin and Retinal Diseases Therapymentioning

confidence: 99%

Curcumin: A new candidate for retinal disease therapy?

Farajipour

Rahimian

Taghizadeh

2018

J of Cellular Biochemistry

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The retina is the neural portion and light‐sensitive layer of the eye, which has been observed in most of the vertebrates. The retina is composed of light‐sensitive cells that absorb light and convert it into neural signals. These signals are sent to the brain for visual recognition. It has been shown that many pathogenesis conditions, including inﬂammation, angiogenesis, oxidative stress, and imbalanced histone modiﬁcations in the retina are associated with initiation and progression of retinal diseases (ie, glaucoma, diabetic retinopathy, and age‐related macular degeneration). Currently available treatments include laser surgery, freezing, stem‐cell therapy, shrinking abnormal blood vessels. It has some limitations, such as invasive methods, high costs, and many side effects. Hence, finding a new therapeutic platform for stopping or slowing of the disease progression is required. Curcumin is a natural product, which is associated with a wide range of properties, such as antioxidant, anti‐inflammatory, antiangiogenic, and antitumor activates. It exerts therapeutic effects via activation/inhibition cellular and molecular targets involved in various diseases, such as retinal diseases. Increasing evidence revealed that curcumin can be used as a therapeutic option in the treatment of different retinal diseases. Here, we summarized various clinical and preclinical studies that used curcumin as a therapeutic agent in the treatment of retinal disorders.

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Section: Curcumin and Retinal Diseases Therapymentioning

confidence: 99%

Curcumin: A new candidate for retinal disease therapy?

Farajipour

Rahimian

Taghizadeh

2018

J of Cellular Biochemistry

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“…A large number of studies indicated that a various cellular and molecular targets (e.g., RB1 gene, cancer stem cells, P53 family, epithelial cell adhesion molecule, and reactive oxide species) could contribute to initiation and progression of Rb (Jagadeesan, Khetan, & Mallipatna, ; Singh et al, ). Despite many advances in the recognition of cellular and molecular targets involved in Rb pathogenesis, a thorough understanding of a sequence of cellular and molecular pathways is currently lacking (de Carvalho, de Freitas, & Vargas, ). Hence, it seems that identification of new biomarkers and cellular/molecular targets could be helpful for better understanding of sequence of cellular and molecular pathways underlying in Rb.…”

Section: Introductionmentioning

confidence: 99%

“…Hence, it seems that identification of new biomarkers and cellular/molecular targets could be helpful for better understanding of sequence of cellular and molecular pathways underlying in Rb. Moreover, the finding of new biomarkers could help choose better and effective therapeutic approach (de Carvalho et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Among various biomarkers, microRNAs (miRNAs) have emerged as attractive tools for the detection of Rb in various stages (de Carvalho et al, ; Mirakholi, Mahmoudi, & Heidari, ; Singh et al, ). MiRNAs are known as a class of small non‐coding RNAs which act as cellular and molecular regulators (Hoseini et al, ; Mirzaei, Fathullahzadeh, et al, ; Mirzaei, Yazdi, Salehi, & Mirzaei, ; Moridikia, Mirzaei, Sahebkar, & Salimian, ; Salarinia et al, ).…”

Section: Introductionmentioning

confidence: 99%

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MicroRNAs in retinoblastoma: Potential diagnostic and therapeutic biomarkers

Golabchi

Soleimani‐Jelodar

Aghadoost

et al. 2017

Journal Cellular Physiology

118

121

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Retinoblastoma (Rb) is known as one of important childhood malignancies which due to inactivation of the RB gene (tumor suppressor gene in various patients). The early detection of Rb could provide better treatment for Rb patients. Imaging techniques (e.g., MRI and CT) are known as one of effective diagnosis approaches for detection of patients with Rb. It has been shown that utilization of imaging techniques is associated with some limitations. Hence, identification of new diagnosis approaches might provide a better treatment for Rb patients. Identification of new biomarkers could contribute to better understanding of pathogenesis events involved in Rb and provide new insights into design better treatment approaches for these patients. Among the various biomarkers, microRNAs (miRNAs) have emerged as attractive tools for Rb detection. miRNAs are one classes of small non-coding RNAs which could anticipate in a variety of biological process via targeting sequence of cellular and molecular pathways. Deregulations of these molecules are associated with cancerous condition. Multiple lines of evidence indicated that deregulation of various miRNAs involved in various stages of Rb. Here, we summarized a variety of tissue-specific and circulating miRNAs involved in Rb pathogenesis which could be used as diagnostic, prognostic, and therapeutic biomarkers in Rb patients.

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“…However, the putative molecular mechanisms underlying OS carcinogenesis have not been deciphered completely and still been a challenge yet. Hitherto, cumulative evidences 2–7 have demonstrated that a variety of factors including microRNAs (miRNAs), a group of non-coding RNAs, were involved in OS development. The first study on miRNAs expression in OS published by Gao et al .…”

Section: Introductionmentioning

confidence: 99%

Biological analysis of cancer specific microRNAs on function modeling in osteosarcoma

Wang

Tang

et al. 2017

Sci Rep

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Osteosarcoma (OS) is the most common bone tumor characterized with a high risk of amputation and malignant morbidity among teenagers and adolescents. However, relevant pathogenic/biological mechanisms underlying OS-genesis remains to be ambiguous. The aim of this study was to elucidate functional relationship about microRNAs-mRNAs networks and to identify potential molecular markers via a computational method. Gene expression profile (GSE70415) was recruited from Gene Expression Omnibus. 3856 differentially expressed genes and 250 significantly expressed microRNAs were identified by using GCBI. The results of GO and KEGG pathways associated proteomics analysis indicated that extracellular matrix organization, small molecule metabolic process, cell adhesion (GO IDs: 0030198, 0044281, 0007155) and pathways in cancer, PI3K-Akt signaling pathway, metabolic pathways (pathway IDs: 5200, 4151, 1100) were significantly enriched. In addition, CKMT2, miR-93b-5p, miR-29b-3p were found to be positively/negatively correlated with TP53, EGFR, and MMP members mediated OS development, including angiogenesis, migration and invasion. Further visualization of collective effect of 1181 microRNAs-mRNAs pairs and protein-protein interactions was realized by applying with cytosacpe. In summary, our work provided a better understanding of non-coding regulatory mechanisms of transcriptomics and unraveled essential molecular biomarkers in osteosarcoma.

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Translating microRNAs into biomarkers: What is new for pediatric cancer?

Cited by 37 publications

References 102 publications

Curcumin: A new candidate for retinal disease therapy?

Curcumin: A new candidate for retinal disease therapy?

MicroRNAs in retinoblastoma: Potential diagnostic and therapeutic biomarkers

Biological analysis of cancer specific microRNAs on function modeling in osteosarcoma

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