Translating neuroscience to the front lines: point-of-care detection of neuropsychiatric disorders

Dasgupta, Jayashree; Bhavnani, Supriya; Estrin, Georgia Lockwood; Mukherjee, Debarati; Banerjee, Arpan; Belmonte, Matthew K.; Chakrabarti, Bhismadev; Divan, Gauri; Dawson, Geraldine; Johnson, Mark H.; McPartland, James C.; Singh, Nandini Chatterjee; Patel, Vikram

doi:10.1016/s2215-0366(16)30186-9

Cited by 18 publications

(15 citation statements)

References 10 publications

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“…Technological interventions targeting lower-level skills, such as attentional gaze and joint attention (Wass & Porayska-Pomsta, 2014;Gulsrud et al, 2014) life functioning to assess out-of-game generalisation, a sticking point for many interventions aimed directly at enhancing social communication by the 'front door'. These characteristics make it a candidate for a task-shifting approach (Dasgupta et al, 2016) of parent-delivered intervention with appropriate training and supervision from clinicians, rather than clinic-based intervention by clinicians. In addition to the potential benefits of being more available than resource-heavy specialised intervention, generalisations of skills learnt in the relevant environment can be hypothesised to be more likely.…”

Section: Discussionmentioning

confidence: 99%

A Tablet Computer-Assisted Motor and Language Skills Training Program to Promote Communication Development in Children with Autism: Development and Pilot Study

Weisblatt

Langensiepen

Cook

et al. 2019

International Journal of Human–Computer Interaction

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Autism is a heterogenous condition, encompassing many different subtypes and presentations. Of those people with autism who lack communicative speech, some are more skilled at receptive language than their expressive difficulty might suggest. This disparity between what can be spoken and what can be understood correlates with motor and especially oral motor abilities, and thus may be a consequence of limits to oral motor skill. Point OutWords, tablet-based software targeted for this subgroup, builds on autistic perceptual and cognitive strengths to develop manual motor and oral motor skills prerequisite to communication by pointing or speaking. Although typical implementations of user-centred design rely on communicative speech, Point OutWords users were involved as co-creators both directly via their own nonverbal behavioural choices and indirectly via their communication therapists' reports; resulting features include vectorised, high-contrast graphics, exogenous cues to help capture and maintain attention, customisable reinforcement prompts, and accommodation of open-loop visuomotor control.

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Section: Discussionmentioning

confidence: 99%

A Tablet Computer-Assisted Motor and Language Skills Training Program to Promote Communication Development in Children with Autism: Development and Pilot Study

Weisblatt

Langensiepen

Cook

et al. 2019

International Journal of Human–Computer Interaction

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“…At present, ASD is usually detected at 3–6 years of age ( Landa, 2008 ) and can be diagnosed as early as the age of two ( Charman and Baird, 2002 ). Several existing studies have suggested that an detection and intervention notably improves prognosis ( Nadel and Poss, 2007 ; Dasgupta et al, 2016 ). Inter-brain connectivity measures can be employed to explore social interaction between children and their caregivers for this purpose.…”

Section: Multi-brain Reference Frame Of Functional Neuroimaging and Mmentioning

confidence: 99%

Neural Substrate of Group Mental Health: Insights from Multi-Brain Reference Frame in Functional Neuroimaging

Ray

Roy

Sindhu³

et al. 2017

Front. Psychol.

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Contemporary mental health practice primarily centers around the neurobiological and psychological processes at the individual level. However, a more careful consideration of interpersonal and other group-level attributes (e.g., interpersonal relationship, mutual trust/hostility, interdependence, and cooperation) and a better grasp of their pathology can add a crucial dimension to our understanding of mental health problems. A few recent studies have delved into the interpersonal behavioral processes in the context of different psychiatric abnormalities. Neuroimaging can supplement these approaches by providing insight into the neurobiology of interpersonal functioning. Keeping this view in mind, we discuss a recently developed approach in functional neuroimaging that calls for a shift from a focus on neural information contained within brain space to a multi-brain framework exploring degree of similarity/dissimilarity of neural signals between multiple interacting brains. We hypothesize novel applications of quantitative neuroimaging markers like inter-subject correlation that might be able to evaluate the role of interpersonal attributes affecting an individual or a group. Empirical evidences of the usage of these markers in understanding the neurobiology of social interactions are provided to argue for their application in future mental health research.

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“…The emergence of smaller, more affordable, and more portable MRI scanners ( O’Reilly et al, 2021 ; Sarracanie et al, 2015 ; Wald 2019 ) offers exciting opportunities to address unmet research needs and long-standing health inequities in remote and resource-limited international settings ( Cooley et al, 2020 ; Geethanath and Vaughan 2019 ). Field-based neuroimaging research in low- and middle-income countries (LMICs) can improve local capacity to conduct structural and functional neuroscience studies, expand knowledge of brain injury and neuropsychiatric and neurodevelopmental disorders, and ultimately improve the timeliness and quality of clinical diagnosis and treatment around the globe ( Dasgupta et al, 2016 ; Hussain 2015 ; Illes et al, 2020; Mollura and Lungren 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Emerging ethical issues raised by highly portable MRI research in remote and resource-limited international settings

et al. 2021

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Smaller, more affordable, and more portable MRI brain scanners offer exciting opportunities to address unmet research needs and long-standing health inequities in remote and resource-limited international settings. Field-based neuroimaging research in low- and middle-income countries (LMICs) can improve local capacity to conduct both structural and functional neuroscience studies, expand knowledge of brain injury and neuropsychiatric and neurodevelopmental disorders, and ultimately improve the timeliness and quality of clinical diagnosis and treatment around the globe. Facilitating MRI research in remote settings can also diversify reference databases in neuroscience, improve understanding of brain development and degeneration across the lifespan in diverse populations, and help to create reliable measurements of infant and child development. These deeper understandings can lead to new strategies for collaborating with communities to mitigate and hopefully overcome challenges that negatively impact brain development and quality of life. Despite the potential importance of research using highly portable MRI in remote and resource-limited settings, there is little analysis of the attendant ethical, legal, and social issues (ELSI). To begin addressing this gap, this paper presents findings from the first phase of an envisioned multi-staged and iterative approach for creating ethical and legal guidance in a complex global landscape. Section 1 provides a brief introduction to the emerging technology for field-based MRI research. Section 2 presents our methodology for generating plausible use cases for MRI research in remote and resource-limited settings and identifying associated ELSI issues. Section 3 analyzes core ELSI issues in designing and conducting field-based MRI research in remote, resource-limited settings and offers recommendations. We argue that a guiding principle for field-based MRI research in these contexts should be including local communities and research participants throughout the research process in order to create sustained local value. Section 4 presents a recommended path for the next phase of work that could further adapt these use cases, address ethical and legal issues, and co-develop guidance in partnership with local communities.

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Translating neuroscience to the front lines: point-of-care detection of neuropsychiatric disorders

Cited by 18 publications

References 10 publications

A Tablet Computer-Assisted Motor and Language Skills Training Program to Promote Communication Development in Children with Autism: Development and Pilot Study

A Tablet Computer-Assisted Motor and Language Skills Training Program to Promote Communication Development in Children with Autism: Development and Pilot Study

Neural Substrate of Group Mental Health: Insights from Multi-Brain Reference Frame in Functional Neuroimaging

Emerging ethical issues raised by highly portable MRI research in remote and resource-limited international settings

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