Translation and Validation of 10/66 Dementia Diagnostic Battery in Urdu in Karachi, Pakistan

Khan, Qurat ul Ain; Prince, Martin; Khalid, Wardah; Zulfiqar, Maryam

doi:10.1097/wad.0000000000000359

Cited by 4 publications

(8 citation statements)

References 13 publications

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“…Although our sample size was relatively small, we have demonstrated that the translated and adapted Fijian-Indian version of the 10/66 dementia protocol has adequate sensitivity (92.3%, 95% CI 70.3–99.5) and specificity (93.8%, 95% CI 75.3–99.6), PPV (92.3%), NPV (93.8%), and a Youden’s index of 0.86. We are confident that the Fijian-Indian version of the 10/66 dementia protocol would have similar utility as other versions of 10/66 dementia protocols [ 20 , 21 , 22 ]. To date, the actual extent and impact of dementia in the Fijian-Indian population is unknown.…”

Section: Discussionmentioning

confidence: 91%

“…We used the clinical diagnosis as a reference standard for memory service-based participants, which is accepted and used as the reference standard in clinical dementia studies worldwide [ 20 , 21 , 22 ]. Its validity has been previously demonstrated in multiple studies.…”

Section: Discussionmentioning

confidence: 99%

“…For this study, the diagnostic accuracy was calculated by comparing the 10/66 dementia protocol results against clinical diagnosis (reference standard). This reference standard has been extensively used in similar 10/66 validity studies [ 20 , 21 , 22 ].…”

Section: Methodsmentioning

confidence: 99%

“…The 10/66 dementia research group recognised the importance of developing a culture and education-fair standardised instrument to diagnose dementia in population-based studies [ 18 , 19 , 20 ]. To date, the 10/66 dementia protocol has been translated and validated in many different languages, including Spanish, Portuguese, Urdu, Arabic, and Mandarin [ 20 , 21 , 22 ]. It has a sensitivity and specificity of up to 94% [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Accuracy of 10/66 Dementia Protocol in Fijian-Indian Elders Living in New Zealand

Martínez-Ruiz

Krishnamurthi

Dahiya

et al. 2021

IJERPH

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The 10/66 dementia protocol was developed as a language and culture-fair instrument to estimate the prevalence of dementia in non-English speaking communities. The aim of this study was to validate the 10/66 dementia protocol in elders of Indian ethnicity born in the Fiji Islands (Fijian-Indian) living in New Zealand. To our knowledge, this is the first time a dementia diagnostic tool has been evaluated in the Fijian-Indian population in New Zealand. We translated and adapted the 10/66 dementia protocol for use in in Fijian-Indian people. Individuals (age ≥ 65) who self-identified as Fijian-Indian and had either been assessed for dementia at a local memory service (13 cases, eight controls) or had participated in a concurrent dementia prevalence feasibility study (eight controls) participated. The sensitivity, specificity, positive predictive value, and Youden’s index were obtained by comparing the 10/66 diagnosis and its sub-components against the clinical diagnosis (reference standard). The 10/66 diagnosis had a sensitivity of 92.3% (95% CI 70.3–99.5), specificity of 93.8% (95% CI 75.3–99.6), positive predictive value of 92.3% (95% CI 70.3–99.5), and negative predictive value of 93.8% (95% CI 75.3–99.6). The study results show that the Fijian-Indian 10/66 dementia protocol has adequate discriminatory abilities to diagnose dementia in our sample. This instrument would be suitable for future dementia population-based studies in the Fijian-Indian population living in Aotearoa/New Zealand or the Fiji-Islands.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnostic Accuracy of 10/66 Dementia Protocol in Fijian-Indian Elders Living in New Zealand

Martínez-Ruiz

Krishnamurthi

Dahiya

et al. 2021

IJERPH

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“…Therefore, the 10/66 dementia research group (DRG) diagnostic tool was formulated and validated in various LMICs 2. A pilot study was conducted in Karachi, Pakistan by our group that used 10/66 methodology to validate the 10/66 DRG diagnostic tool in Urdu 3. The 10/66 DRG diagnostic battery not only takes 2 to 3 hours for testing, but also requires specialized and longer training for the data collectors to administer the battery.…”

mentioning

confidence: 99%

Validation of the Short Version of the 10/66 Dementia Diagnosis in Urdu in Karachi, Pakistan

Khan¹,

Prince

2021

Alzheimer Disease &Amp; Associated Disorders

Self Cite

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The standard 10/66 battery has been translated and validated in Pakistan; however, it takes long to administer it with specialized training for the staff. This study was performed to validate a shorter version of the 10/66. The data for validation of the short version was extracted from the full version study. Ethical approval was taken from the Institutional Review Board of the Aga Khan University. The study was funded by the Aga Khan University, University Research Council Grant. The total number of participants was 257, equally divided between people with dementia and normal cognition. The sensitivity of the short version was 95.7% and 80.5%; specificity was 83.5% and 90.7%; κ was 0.751 and 0.712; and the area under the curve was 0.89 and 0.85 against the standard 10/66 diagnosis and clinician diagnosis, respectively. The short version of 10/66 battery is a valid instrument for diagnosing dementia in the Urdu-speaking Pakistani population.

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A systematic review of the status of neuropsychological research and dementia in South Asia

2023

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It is recognised that there is a notable presence of psychology and dementia-related issues in South Asian (SA) countries, and this problem is on the rise. Nevertheless, the problems found in the field of neuropsychology are yet to be fully resolved in the region. Unlike the case in developed countries, neuropsychology, despite the scopes and genuine potential, is not broadly practised in South Asia (which constitutes 25% of the world population), and the opportunity for extensive research is limited. Although India has made substantial progress in neuropsychology through the establishment of neuropsychological units and by developing assessment modules based on cultural requirements and the living standards of the population, the rest of the South Asia region is lagging far behind in the sphere of health science. Neuropsychology covers a vast area of brain-behaviour relationships, of which cognitive impairment is an important part. Except for India, other South Asian countries like Pakistan, Bangladesh, Sri Lanka, and Nepal have not had specific noteworthy studies on neuropsychology, but there have been a few research works done on neuropsychology, cognitive impairment, and other neurological assessments. This article focuses on reviewing the status of the development of neuropsychological research in South Asia, and it also assesses quantitative studies on dementia in the region where cognitive and neuropsychological assessments have been used.

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Translation and Validation of 10/66 Dementia Diagnostic Battery in Urdu in Karachi, Pakistan

Cited by 4 publications

References 13 publications

Diagnostic Accuracy of 10/66 Dementia Protocol in Fijian-Indian Elders Living in New Zealand

Diagnostic Accuracy of 10/66 Dementia Protocol in Fijian-Indian Elders Living in New Zealand

Validation of the Short Version of the 10/66 Dementia Diagnosis in Urdu in Karachi, Pakistan

A systematic review of the status of neuropsychological research and dementia in South Asia

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