Translation elongation factor 1B (eEF1B) is an essential host factor for Tobacco mosaic virus infection in plants

Hwang, Jin‐Ki; Oh, Chang‐Sik; Kang, Byoung−Cheorl

doi:10.1016/j.virol.2013.02.004

Cited by 53 publications

(41 citation statements)

References 65 publications

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“…In some organisms eEF1B also includes a valyl tRNA synthetase. Very little is known specifically about eEF1B from plants other than it has been purified from wheat germ (Lauer et al, 1984) and was shown to play a role in viral replication (Sasvari et al, 2011;Hwang et al, 2013), as have eEF1A (Matsuda et al, 2004;Li and Nagy, 2011) and cap-binding complex subunits (Wang and Krishnaswamy, 2012).…”

Section: Eef1bmentioning

confidence: 99%

Mechanism of Cytoplasmic mRNA Translation

Browning

Bailey‐Serres

2015

The Arabidopsis Book

190

220

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Protein synthesis is a fundamental process in gene expression that depends upon the abundance and accessibility of the mRNA transcript as well as the activity of many protein and RNA-protein complexes. Here we focus on the intricate mechanics of mRNA translation in the cytoplasm of higher plants. This chapter includes an inventory of the plant translational apparatus and a detailed review of the translational processes of initiation, elongation, and termination. The majority of mechanistic studies of cytoplasmic translation have been carried out in yeast and mammalian systems. The factors and mechanisms of translation are for the most part conserved across eukaryotes; however, some distinctions are known to exist in plants. A comprehensive understanding of the complex translational apparatus and its regulation in plants is warranted, as the modulation of protein production is critical to development, environmental plasticity and biomass yield in diverse ecosystems and agricultural settings.

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Section: Eef1bmentioning

confidence: 99%

Mechanism of Cytoplasmic mRNA Translation

Browning

Bailey‐Serres

2015

The Arabidopsis Book

190

220

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“…In Arabidopsis, maltose transporter mutant line (mex1), a typical growth retardation and exceptional chlorotic phenotype, was observed. Those mex1 lines were observed to sustain stress condition raised due to blockage of maltose export, and a GLP (GLP3, At5g20630) was found to be upregulated in those lines (Hwang et al 2013) indicating the involvement of GLPs in those circumstances. A GLP from Citrus limon (ClGLP) was found to show the highest level of expression in mature fruit especially during the transition phase from green to yellow stages of fruit growth (Bruno et al 2014).…”

Section: Glp Expression At Later Stages Of Growthmentioning

confidence: 99%

Versatility of germin-like proteins in their sequences, expressions, and functions

Barman

Banerjee

2015

Funct Integr Genomics

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Germin-like proteins (GLPs) are evolutionary conserved ubiquitous plant glycoproteins belonging to the cupin superfamily. A large number of GLP family members have been identified from different higher and lower plant species, and those have been classified into different subfamilies. Although three histidine residues (H) and one glutamate residue (E) in germin box B and C were conserved among all the GLP subfamily members, how the sequences of one subfamily member differ from the other is unclear. Progress in the field of genomics, transcriptomics, and proteomics has made it possible to understand the variation at gene level among different GLP members from diverse genera and also their biological significances. GLPs from different plant species were found to have various enzymatic properties including oxalate oxidase (OxO), superoxide dismutase (SOD), ADP glucose pyrophosphatase/phosphodiesterase (AGPPase), and polyphenol oxidase (PPO) activities. 'Omics' study demonstrated the expression as well as involvement of GLP family members in almost every part of higher plants as well as in lower plants. Additionally, GLPs from different species were reported to be involved in biotic as well as abiotic stresses and also in the growth and development. This review describes the present research status of GLPs from different plant species, their expressions, and functional significances. Sequence variation was detected among GLP subfamily members at the amino acid level, and based on the sequence variation and phylogenetic analyses, two new GLP subfamilies have been proposed in this review.

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“…eEF1A also interacts with the 3 UTR of TMV genomic RNA (146) and the ORF6 protein (39). eEF1B, another subunit of eEF1 and the counterpart of E. coli EF-Ts, which is also a subunit of Qβ replicase, interacts with the methyltransferase domain of TMV replication proteins, and knockdown of the eEF1B gene affects TMV multiplication in N. benthamiana leaves (55). Thus, eEF1A and eEF1B are required for efficient viral RNA replication and/or spread in leaves.…”

Section: Host Factors Involved In Tobamovirus Rna Replicationmentioning

confidence: 99%

Replication of Tobamovirus RNA

Ishibashi

Ishikawa

2016

Annu. Rev. Phytopathol.

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Tobacco mosaic virus and other tobamoviruses have served as models for studying the mechanisms of viral RNA replication. In tobamoviruses, genomic RNA replication occurs via several steps: (a) synthesis of viral replication proteins by translation of the genomic RNA; (b) translation-coupled binding of the replication proteins to a 5'-terminal region of the genomic RNA; (c) recruitment of the genomic RNA by replication proteins onto membranes and formation of a complex with host proteins TOM1 and ARL8; (d) synthesis of complementary (negative-strand) RNA in the complex; and (e) synthesis of progeny genomic RNA. This article reviews current knowledge on tobamovirus RNA replication, particularly regarding how the genomic RNA is specifically selected as a replication template and how the replication proteins are activated. We also focus on the roles of the replication proteins in evading or suppressing host defense systems.

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Translation elongation factor 1B (eEF1B) is an essential host factor for Tobacco mosaic virus infection in plants

Cited by 53 publications

References 65 publications

Mechanism of Cytoplasmic mRNA Translation

Mechanism of Cytoplasmic mRNA Translation

Versatility of germin-like proteins in their sequences, expressions, and functions

Replication of Tobamovirus RNA

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