Translation of New Technologies in Biomedicines: Shaping the Road from Basic Research to Drug Development and Clinical Application–and Back Again

The Use of Integrated and Intelligent Testing Strategies in the Prediction of Toxic Hazard and in Risk Assessment

“…There is a vast and rapidly-expanding literature on this subject and all we can do here is to give a few examples, including some recent and comprehensive reviews. [33][34][35] 1. The use of existing knowledge.…”

Modern Alternative Approaches to the Problem of Drug-induced Liver Injury

“…It does not include developments in relation to in silico technology, high content screening, the omics approaches, physiologically-based pharmacokinetic (PBPK) models, virtual tissue models, virtual patient populations, biomarkers and clinical imaging, which are also of great significance, especially when used in combination with, and with the benefit of, bioinformatics and systems biology approaches. 6 1. Cell fractions: Short-term studies can be conducted with cell fractions and isolated cell components, such as nuclei, membranes, mitochondria and receptors.…”

“…At one extreme of a spectrum of methods will be inexpensive, highthroughput systems applicable to large numbers of chemicals at the drug discovery stage, while at the other extreme will be more-sophisticated and expensive systems appropriate for use at much later stages of product development, and even with individual patients. FRAME-associated scientists are involved in these developments, for example, by editing a book on New Technologies for Toxicity Testing, due to be published in July 2011, 5 and by writing chapters for Pharmaceutical Biotechnology -A Compre hensive Handbook 6 and Implant Dentistry Research Guide: Basic, Translational and Experimental Clinical Research. 7 The FRAME Alternatives Laboratory (FAL), in the University of Nottingham's School of Biomedical Sciences, is currently actively involved in the development of DILI testing methods based on the use of patient-derived hepatocytes.…”

“…FRAME-associated scientists are involved in these developments, for example, by editing a book on New Technologies for Toxicity Testing, due to be published in July 2011, 5 and by writing chapters for Pharmaceutical Biotechnology -A Compre hensive Handbook 6 and Implant Dentistry Research Guide: Basic, Translational and Experimental Clinical Research. 7 The FRAME Alternatives Laboratory (FAL), in the University of Nottingham's School of Biomedical Sciences, is currently actively involved in the development of DILI testing methods based on the use of patient-derived hepatocytes.…”