Translational considerations for immunotherapy clinical trials in pediatric neuro-oncology

Foster, Jessica; Zalacaín, Marta; Sayour, Elias; Davidson, Tom B.; Persson, Mika L.; Dun, Matthew D.; Kline, Cassie; Mueller, Sabine; Vitanza, Nicholas A.

doi:10.1016/j.neo.2023.100909

Neoplasia

2023

DOI: 10.1016/j.neo.2023.100909

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Translational considerations for immunotherapy clinical trials in pediatric neuro-oncology

Jessica Foster

Marta Zalacaín

Elias Sayour

et al.

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Cited by 6 publications

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BioDrugs

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Chimeric antigen receptor T cell therapy has been established in the treatment of various B cell malignancies. However, translating this therapeutic effect to treat solid tumors has been challenging because of their inter-tumoral as well as intratumoral heterogeneity and immunosuppressive microenvironment. Local interventions, such as surgery, radiotherapy, local ablation, and locoregional drug delivery, can enhance chimeric antigen receptor T cell therapy in solid tumors by improving tumor infiltration and reducing systemic toxicities. Additionally, ablation and radiotherapy have proven to (re-)activate systemic immune responses via abscopal effects and reprogram the tumor microenvironment on a physical, cellular, and chemical level. This review highlights the potential synergy of the combined approaches to overcome barriers of chimeric antigen receptor T cell therapy and summarizes recent studies that may pave the way for new treatment regimens.

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Prospects of Synergy: Local Interventions and CAR T Cell Therapy in Solid Tumors

Holtermann,

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et al. 2024

BioDrugs

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Translational considerations for immunotherapy clinical trials in pediatric neuro-oncology

Cited by 6 publications

References 137 publications

Prospects of Synergy: Local Interventions and CAR T Cell Therapy in Solid Tumors

Prospects of Synergy: Local Interventions and CAR T Cell Therapy in Solid Tumors

Targeting molecular mechanisms underlying treatment efficacy and resistance in DIPG: A review of current and future strategies

Recent advances in development and delivery of non-viral nucleic acid therapeutics for brain tumor therapy

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