2011
DOI: 10.1111/j.1365-2249.2011.04469.x
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Translational Mini-Review Series on B cell subsets in disease. Reconstitution after haematopoietic stem cell transplantation – revelation of B cell developmental pathways and lineage phenotypes

Abstract: SummaryHaematopoietic stem cell transplantation (HSCT) is an immunological treatment that has been used for more than 40 years to cure a variety of diseases. The procedure is associated with serious side effects, due to the severe impairment of the immune system induced by the treatment. After a conditioning regimen with high-dose chemotherapy, sometimes in combination with total body irradiation, haematopoietic stem cells are transferred from a donor, allowing a donor-derived blood system to form. Here, we di… Show more

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Cited by 57 publications
(62 citation statements)
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References 118 publications
(140 reference statements)
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“…Thus, an important implication of our findings is that CD40-mediated shaping of the mature BCR repertoire may facilitate efficient humoral immune responses to neoantigens. Consistent with this idea, many patients have poor responses to pneumococcal vaccines following BM transplant, despite having reconstituted normal B cell numbers, and T cell targeting to mitigate graft-versus-host disease further exaggerates this defect (53). In addition, the altered BCR repertoire generated in the absence of CD40 signals may promote autoimmunity because hyper-IgM patients lacking CD40L suffer from various autoimmune symptoms (54).…”
Section: /2mentioning
confidence: 64%
“…Thus, an important implication of our findings is that CD40-mediated shaping of the mature BCR repertoire may facilitate efficient humoral immune responses to neoantigens. Consistent with this idea, many patients have poor responses to pneumococcal vaccines following BM transplant, despite having reconstituted normal B cell numbers, and T cell targeting to mitigate graft-versus-host disease further exaggerates this defect (53). In addition, the altered BCR repertoire generated in the absence of CD40 signals may promote autoimmunity because hyper-IgM patients lacking CD40L suffer from various autoimmune symptoms (54).…”
Section: /2mentioning
confidence: 64%
“…One limitation of this study is that the combination of CD24 and CD38 was not included in the flow cytometry panel, because these markers have been acknowledged to distinguish different peripheral B cell maturational stages in humans after the FARMFLORA study was initiated in 2004 (7,8). However, with the use blood samples from healthy unselected children and adults, we sought to examine whether CD5 in combination with CD24 and CD38 could verify that CD5 + B cells were immature/ naive.…”
Section: Discussionmentioning
confidence: 99%
“…After the FARMFLORA study was initiated, cell-surface expression of CD24 in combination with CD38 has been acknowledged to distinguish different human B cell maturational stages in the periphery (7,8). Thus, we examined whether the expression of CD24 and CD38 could verify that the CD5 + B cells in blood samples from unselected healthy newborn children, 7-y-old children, and healthy adults were immature/naive B cells.…”
Section: Cd5 + B Cells Are Of An Immature/naive Phenotypementioning
confidence: 99%
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“…11 BM-emigrating transitional B cells appear in blood within the first months after allo-HSCT and are progressively replaced with recovering naïve B cells. 12,13 Germinal-center (GC) defects contribute to the slow regeneration of isotype-class switched CD27 1 memory B cells, which correlates with long-term antibody class deficiencies in some patients.…”
Section: Introductionmentioning
confidence: 99%