Translocation heterozygosity in a malformed piglet and its normal littermates

Miyake, Yoh-Ichi; Kawata, Keiichiro; Ishikawa, Tomokazu; Umezu, Masatoshi

doi:10.1002/tera.1420160209

Cited by 12 publications

(2 citation statements)

References 15 publications

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“…Robertsonian translocations, and especially tandem fusions, are by contrast relatively rare chromosomal events in the domestic pig. Just seven cases of Robertsonian translocation have been described in the pig, primarily cases of the same rob(13;17) rearrangement endemic in wild pigs [ 4 , 8 , 55 , 56 , 57 ]. Robertsonian translocation is known to occur in the acrocentric chromosomes 13, 14, 15, 16, 17, and 18.…”

Section: Robertsonian Translocations and Tandem Fusionsmentioning

confidence: 99%

Classical, Molecular, and Genomic Cytogenetics of the Pig, a Clinical Perspective

Donaldson

Villagómez

King

2021

Animals

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The chromosomes of the domestic pig (Sus scrofa domesticus) are known to be prone to reciprocal chromosome translocations and other balanced chromosome rearrangements with concomitant fertility impairment of carriers. In response to the remarkable prevalence of chromosome rearrangements in swine herds, clinical cytogenetics laboratories have been established in several countries in order to screen young boars for chromosome rearrangements prior to service. At present, clinical cytogenetics laboratories typically apply classical cytogenetics techniques such as giemsa-trypsin (GTG)-banding to produce high-quality karyotypes and reveal large-scale chromosome ectopic exchanges. Further refinements to clinical cytogenetics practices have led to the implementation of molecular cytogenetics techniques such as fluorescent in-situ hybridization (FISH), allowing for rearrangements to be visualized and breakpoints refined using fluorescently labelled painting probes. The next-generation of clinical cytogenetics include the implementation of DNA microarrays, and next-generation sequencing (NGS) technologies such as DNA sequencing to better explore tentative genome architecture changes. The implementation of these cytogenomics techniques allow the genomes of rearrangement carriers to be deciphered at the highest resolution, allowing rearrangements to be detected; breakpoints to be delineated; and, most importantly, potential gene implications of those chromosome rearrangements to be interrogated. Clinical cytogenetics has become an integral tool in the livestock industry, identifying rearrangements and allowing breeders to make informed breeding decisions.

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Section: Robertsonian Translocations and Tandem Fusionsmentioning

confidence: 99%

Classical, Molecular, and Genomic Cytogenetics of the Pig, a Clinical Perspective

Donaldson

Villagómez

King

2021

Animals

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“…The main achievement during the period following the reports on the 1/29 translocation was the discovery of a variety of chromosome anomalies related to infertility and poor viability in farm animals, using the Giessener System in Germany (Rieck, 1984) and other chromosome errors including Robertsonian type translocations in cattle (Popescu, 1971(Popescu, , 1977, pigs (McFee et al, 1966;McFee and Banner, 1969;Masuda et al, 1975;Miyake et al, 1977;Alonso and Cantu, 1982), goats (Padeh et al, 1965(Padeh et al, , 1971Soller et al, 1966;Hulot, 1969Hulot, , 1970Sohrab et al, 1973) and sheep (Bruere, 1969(Bruere, , 1974Bruere et al, 1976Bruere et al, , 1978. Since these translocations were detected mainly on the basis of the overt appearance of the altered chromosomes, the identity of the chromosomes involved in some of these translocations reported earlier was not unequivocally established.…”

Section: Cytogenetics and Animal Reproductionmentioning

confidence: 99%

Veterinary cytogenetics: past and perspective

Basrur

Stranzinger²

2008

Cytogenet Genome Res

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Cytogenetics was conceived in the late 1800s and nurtured through the early 1900s by discoveries pointing to the chromosomal basis of inheritance. The relevance of chromosomes to human health and disease was realized more than half a century later when improvements in techniques facilitated unequivocal chromosome delineation. Veterinary cytogenetics has benefited from the information generated in human cytogenetics which, in turn, owes its theoretical and technical advancement to data gathered from plants, insects and laboratory mammals. The scope of this science has moved from the structure and number of chromosomes to molecular cytogenetics for use in research or for diagnostic and prognostic purposes including comparative genomic hybridization arrays, single nucleotide polymorphism array-based karyotyping and automated systems for counting the results of standard FISH preparations. Even though the counterparts to a variety of human diseases and disorders are seen in domestic animals, clinical applications of veterinary cytogenetics will be less well exploited mainly because of the cost-driven nature of demand on diagnosis and treatment which often out-weigh emotional and sentimental attachments. An area where the potential of veterinary cytogenetics will be fully exploited is reproduction since an inherited aberration that impacts on reproductive efficiency can compromise the success achieved over the years in animal breeding. It is gratifying to note that such aberrations can now be tracked and tackled using sophisticated cytogenetic tools already commercially available for RNA expression analysis, chromatin immunoprecipitation, or comparative genomic hybridization using custom-made microarray platforms that allow the construction of microarrays that match veterinary cytogenetic needs, be it for research or for clinical applications. Judging from the technical refinements already accomplished in veterinary cytogenetics since the 1960s, it is clear that the importance of the achievements to date are bound to be matched or out-weighed by what awaits to be accomplished in the not-too-far future.

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Polymorphism of metaphase chromosomes in swine (Sus scrofa L.)

Sysa¹

1980

Genetica

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Cytogenetic studies to date on domestic swine (Sus scrofa domesticus) and wild swine (Sus scrofa fetus)show that a significant role is played by the fission or fusion process of acrocentric chromosomes in the evolution of their karyotypes. This process is connected in swine mainly with two pairs of acrocentric chromosomes. It provides in wild swine a karyotype of 2n = 36, in domestic swine 2n = 38, and in crossbreeds 2n = 37 (McFee et al.

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Translocation heterozygosity in a malformed piglet and its normal littermates

Cited by 12 publications

References 15 publications

Classical, Molecular, and Genomic Cytogenetics of the Pig, a Clinical Perspective

Classical, Molecular, and Genomic Cytogenetics of the Pig, a Clinical Perspective

Veterinary cytogenetics: past and perspective

Polymorphism of metaphase chromosomes in swine (Sus scrofa L.)

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