On the podzolized chernozem, where the increased level of contamination with heavy metals (Cu, Zn, Pb, Cd) was modeled, a certain dynamics of crop yields was observed. Mineral, organo-mineral and organic fertilizer systems in crop rotation were studied as a possibility of using detoxicants. The studied fertilizer systems increase the productivity of soil contaminated with heavy metals by 34 – 109%. The most effective fertilizer system (79.4 c/ha of feed units) turned out to be organo-mineral. When using only organic or mineral fertilizers, the efficiency decreased (27.9 – 55.5 c/ha of feed units) in relation to the control variant.